1. The role of functional foods, nutraceuticals, and food supplements in intestinal healthAvrelija Cencič, Walter Chingwaru, 2010, review article Abstract: New eating habits, actual trends in production and consumption have a healyh, environmental and social impact. The EU is fighting diseases characteristics of a modern age, such as obesity, osteoporosis, cancer, diabetes, allergies and dental problems. Developed countries are also faced with problems relatingto aging populations, high energy foods, and unbalanced diets. The potential of nutraceuticals/functional foods/food supplements in mitigating health problems, especially in the gastrointestinal (GI) tract, is discused. Certain members of gut microflora (e.g., probiotic/protective strains) play a role in the host health due to its involvment in nutritional, immunologic and physiologic functions. The potential mechanisms by which nutraceuticals/functional foods/food supplements may alter a host's health arealso highlighted in this paper. The establishment of novel functional call models of the GI and analytical tools that allow tests in controlled experiments are highly desired for gut research.
Keywords: nutraceutical, functional food, food supplement, intestinal health, probiotic, intestinal cell models, gut research
Published in DKUM: 22.06.2017; Views: 1937; Downloads: 418
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2. Application of gut cell models for toxicological and bioactivity studies of functional and novel foodsMartin Trapečar, Avrelija Cencič, 2012, review article Abstract: The concept of functional and novel foods undoubtedly bears great potential as an asset to human health. However, this very same quest for ever new bioactive ingredients calls for reliable and distinct risk assessment as they may be potentially hazardous to human health. Most of today's methodologies still rely on decades old routines of animal trials and use of tumor-derived cell lines. Since such methodologies are not in line with the actual processesin the human body and with the 3R (replacement, reduction, refinement) concept, the results are often unreliable and misleading. Therefore, in this paper we propose the utilization of available untransformedsmall intestinal cell lines derived from human and pig tissue of non-tumor origin and describe several available cell models of the gut that offer a functional, close resemblance with the in vivo environment.
Keywords: gut, cell models, risk assessment, toxicology, functional food
Published in DKUM: 10.07.2015; Views: 1639; Downloads: 100
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