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Time-dependent behaviour of reinforced cuts in weathered flysch rock masses
Mirko Grošić, Željko Arbanas, 2014, izvirni znanstveni članek

Opis: Knowledge of stress-strain rock mass behaviour is crucial for many engineering purposes. Rock mass deformations and their influences on construction are observed during construction and even during exploitation phases. These deformations in the exploitation phase are caused by the time-dependent behaviour of the rock mass. A flysch rock mass is categorised as a heterogenic weak rock that has been intensely subjected to weathering processes. Due to weathering processes, the flysch rock mass degrades from fresh rock to residual soil within only a few meters of the geological profile below the surface. Observations of reinforced cuts along the Adriatic motorway near the City of Rijeka, Croatia, were conducted over a time period of seven years of spanning construction and exploitation. Measured displacements reached significant magnitudes during the exploitation period as a consequence of the time-dependent behaviour of the rock mass. The paper presents findings related to flysch rock mass weathering profile and its characteristics based on detailed geotechnical investigations and monitoring results coupled with back analyses. It was found possible to detect the thickness of the flysch rock mass weathering profile by performing detailed geotechnical investigations. Recommendations for the strength, deformation, and creep properties of the weathering profile of a flysch rock mass are given.
Ključne besede: time-dependent behaviour, weathering, weak rock mass, Burger model, back analyses
Objavljeno: 14.06.2018; Ogledov: 448; Prenosov: 39
.pdf Celotno besedilo (700,29 KB)
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New trends in rock mass characterisation for designing geotechnical structures
Drago Ocepek, 2005, izvirni znanstveni članek

Opis: The investigation on designing supporting measures for geotechnical structures consists of the proper selection of the input data for the stress – strain analysis of the excavation process and the selection of retaining measures. In the preliminary phase of investigation the area must be geologically mapped in detail, and discontinuities precisely measured, boreholes and their “in situ” tests listed and samples for laboratory examinations taken. The new method allows rock mass classification for different rock quality, from soft rocks to mixed rock masses, as well as determination of the geological strength index GSI. The limits for using the suggested method are persistent discontinuities in rock mass which lead to translation or rotation failure mechanisms, either in a single plane or as a wedge. In all cases where discontinuities play a significant role, the rock mass structure must be considered and kinematical analyses performed. In other circumstances, a rock may be uniform and reasonably isotropic due to the geometry of discontinuities and their mutual intersections. The value range of GSI is first determined in the beginning of investigation and later in the excavation phase by considering the disturbance factor D, which expresses disturbances caused by excavation methods and rock mass relaxation. The strength and deformability parameters of rocks of different quality are determined by the generalized Hoek-Brown failure criterion and applied to shallow and deep tunnels or slopes. Before the start of excavations work and after establishing the retaining measures, the analysis results are checked by monitoring. New methods include the determination of post peak strength parameters of rock mass after relaxation, and routine measurements. The newest measurement system however allows direct readings of displacements of the rock mass in both the elastic and post-peak states. With back analyses we determine the softening behavior of the rock mass and a possible need for increasing retaining measures. Such a design method enables the optimization of retaining measures and the reduction of investment costs.
Ključne besede: geological strength index – GSI, simulation of a triaxial large scale »in situ« test, numerical modeling, retaining measures, rock reinforcement, monitoring, back analyses, strain softening, rock mass relaxation
Objavljeno: 16.05.2018; Ogledov: 587; Prenosov: 30
.pdf Celotno besedilo (1,05 MB)
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Simultaneous GC-MS determination of free and bound phenolic acids in Slovenian red wines and chemometric characterization
Milena Ivanović, Maša Islamčević Razboršek, Mitja Kolar, 2016, izvirni znanstveni članek

Opis: Several phenolic acids (PAs), caffeic, vanillic, syringic, p-coumaric and ferulic acid, found in Slovenian red wines were studied using gas chromatography and mass spectrometry (GC-MS). For isolation of the PAs from wine samples, solid phase extraction (SPE) using hydrophilic modified styrene - HLB cartridges was used. The bound PAs were extracted after basic hydrolysis and o-coumaric acid was used as the internal standard (ISTD). The method developed was validated and the linear concentration range for all analytes was from 1 to 100 mg L$^{-1}$ with correlation coefficients above 0.999. We show that the method is repeatable (RSD<2%), recoveries were above 96%, and LOD and LOQ values were acceptable. In all of the wine samples tested, caffeic and p-coumaric acid were determined to be the predominant PAs (17-72 mg L$^{-1}$), while other compounds were found in lower concentrations. Principal Component Analysis (PCA) and Cluster Analysis (CLU) were used to study differences between wines related towards varieties and Slovenian wine regions. The results demonstrate that variety has more influence on PAs content than wine regions in Slovenian red wines.
Ključne besede: phenolic acids, Slovenian red wines, gas chromatography, mass spectrometry, PCA, CLU
Objavljeno: 25.08.2017; Ogledov: 1355; Prenosov: 304
.pdf Celotno besedilo (222,27 KB)
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Saponification reaction system
Darja Pečar, Andreja Goršek, 2015, izvirni znanstveni članek

Opis: The saponification of an aromatic ester with an aqueous sodium hydroxide was studied within a heterogeneous reaction medium in order to determine the overall kinetics of the selected system. The extended thermo-kinetic model was developed compared to the previously used simple one. The reaction rate within a heterogeneous liquid-liquid system incorporates a chemical kinetics term as well as mass transfer between both phases. Chemical rate constant was obtained from experiments within a homogeneous medium, whilst the mass-transfer coefficient was determined separately. The measured thermal profiles were then the bases for determining the overall reaction-rate. This study presents the development of an extended kinetic model for considering mass transfer regarding the saponification of ethyl benzoate with sodium hydroxide within a heterogeneous reaction medium. The time-dependences are presented for the mass transfer coefficient and the interfacial areas at different heterogeneous stages and temperatures. The results indicated an important role of reliable kinetic model, as significant difference in $k_La$ product was obtained with extended and simple approach.
Ključne besede: chemical kinetics, mass transfer, saponification, heterogeneous system
Objavljeno: 25.08.2017; Ogledov: 786; Prenosov: 93
.pdf Celotno besedilo (156,61 KB)
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Determination of topiramate in human plasma using liquid chromatography tandem mass spectrometry
Tanja Vnučec, Lea Cvitkovič-Maričič, Helena Prosen, Darinka Brodnjak-Vončina, 2013, izvirni znanstveni članek

Opis: The LC-MS/MS method for determination of the anti-epileptic drug topiramate (TPM) in human plasma was developed and validated for pharmacokinetic and bioequivalence study purposes. For quantitative determination of TPM values the method with deuterated internal standard (topiramate-d12) and liquid chromatography with tandem mass spectrometry was used. TPM was extracted from the human plasma using the solid-phase extraction procedure on a Strata X extraction column. Negative ions were monitored in the selected reaction monitoring mode (SRM) and transitions m/z 338.2 > 78.2 and m/z 350.3 > 78.2 were used for the quantitative evaluation of TPM and the internal standard, respectively. The results obtained from validation were statistically evaluated according to the requirements of European Medicines Agency (EMA) and Food and Drug Administration (FDA) regulatory guidelines. The linearity of the method was checked within a concentration range from 10 to 2000 ng/mL. Successful validation confirmed that this method is precise, accurate, sensitive and therefore suitable for determination of topiramate plasma levels in pharmacokinetic and bioequivalence studies.
Ključne besede: topiramate, liquid chromatography tandem mass spectroscopy, human plasma, bioequivalence study
Objavljeno: 18.08.2017; Ogledov: 854; Prenosov: 58
.pdf Celotno besedilo (189,19 KB)
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Determination of candesartan in human plasma with liquid chromatography - tandem mass spectrometry
Vanja Forjan, Lea Cvitkovič-Maričič, Helena Prosen, Darinka Brodnjak-Vončina, 2016, izvirni znanstveni članek

Opis: A sensitive, specific and rapid liquid chromatography - tandem mass spectrometry method was developed and validated for the determination of candesartan in human plasma. Analyte was separated from endogenous components present in plasma by solid phase extraction. Chromatographic separation was performed on Gemini C18 analytical column using mobile phase acetonitrile – 5 mM ammonium formate pH 2 (90:10, v/v) at flow rate of 0.3 mL/min. For detection, tandem mass spectrometry in SRM mode with positive electrospray ionization was used. The mass transitions m/z 441.1 > 263.1 and 445.1 > 267.1 were used to determine candesartan by using candesartan-d4 as an internal standard. After development, the method was validated according to the requirements of EMA regulatory guidelines in the concentration range 1 - 400 ng/ml in human plasma. Limit of quantification (LLOQ) was 1 ng/ml. The developed and validated method proved to be very fast and reproducible and was therefore successfully implemented in pharmacokinetic and bioequivalence studies with large number of study samples.
Ključne besede: candesartan, liquid chromatography, tandem mass spectrometry, human plasma
Objavljeno: 17.08.2017; Ogledov: 820; Prenosov: 302
.pdf Celotno besedilo (215,54 KB)
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Financial aspects of a seismic base isolation system for a steel high-rack structure
Vojko Kilar, Simon Petrovčič, Simon Šilih, David Koren, 2013, izvirni znanstveni članek

Opis: The paper deals with the effects and costs of implementing a base isolation system for the mitigation of the seismic risk of an existing steel rack structure. Different realistic distributions of the payload mass and occupancy levels, which form different plan asymmetric variants, have been analysed. The results obtained by the pushover analysis (N2 method) are presented as top floor envelopes and as plastic hinge damage patterns. In the presented cost study, the cost of the implementation of the proposed base isolation system is compared with the estimated costs of structural repairs to the damaged structural members of the superstructure, as well as with estimated expenses of the downtime period. The results have shown that base isolation is, in general, not economically feasible for lower ground motion intensities, whereas it could be of great benefit in the case of moderate and high intensities, especially if the downtime period is taken into account.
Ključne besede: rack structures, seismic behaviour, base isolation, cost efficiency, mass eccentricity, pushover analysis
Objavljeno: 07.08.2017; Ogledov: 529; Prenosov: 76
.pdf Celotno besedilo (999,00 KB)
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Increased augmentation index and central systolic arterial pressure are associated with lower school and motor performance in young adolescents
Bernarda Vogrin, Marjan Rupnik, Dušanka Mičetić-Turk, 2017, izvirni znanstveni članek

Opis: Objective: In adults, improper arterial function has been linked to cognitive impairment. The pulse wave velocity (PWV), augmentation index (AIx) and other vascular parameters are useful indicators of arterial health. In our study, we monitored arterial properties, body constitution, school success, and motor skills in young adolescents. We hypothesize that reduced cognitive and motor abilities have a vascular origin in children. Methods: We analysed 81 healthy school children aged 11-16 years. Anthropometry central systolic arterial pressure, body mass index (BMI), standard deviation scores (SDS) BMI, general school performance grade, and eight motor tests were assessed. PWV, AIx, and central systolic arterial pressure (SBPao) were measured. Results: AIx and SBPao correlated negatively with school performance grades. Extremely high AIx, PWVand SBPao values were observed in 5% of children and these children had average to low school performance. PWV correlated significantly with weight, height, and waist and hip circumference. AIx, PWV, school success, and BMI correlated strongly with certain motor functions. Conclusions: Increased AIx and SBPao are associated with lower school and motor performance in children. PWV is influenced by the body's constitution.
Ključne besede: augmentation index, pulse wave velocity, school success, motor functions, young adolescents, central systolic arterial pressure, body mass index
Objavljeno: 13.07.2017; Ogledov: 555; Prenosov: 265
.pdf Celotno besedilo (160,29 KB)
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Tanja Vidmajer, 2016, diplomsko delo

Opis: My diploma thesis deals with the television series Mad Men and the film Revolutionary Road. The first part of the thesis consists of short summaries of both works as well as descriptions of the two married couples as main character figures from each story, the Drapers and the Wheelers. Firstly, the main part of the thesis discusses American post-war domestic ideology and the meaning of identity through a detailed analysis and comparison of the main protagonists and their relationships. Additionally, the thesis reveals how conformity, domestic containment, the banality of suburban life, consumerism, strictly defined gender roles, superficial marriages and the loss of one’s true identity lead to adultery and the destruction of the protagonists’ true selves. Secondly, alienation, a sense of frustration and silent despair inevitably culminate in the break-up of their marriages. Thirdly, the conflict between the actual and projected identities of the character roles they are bound to play becomes so major that the utopian aspirations of living their lives in the American dream are shattered into pieces. The inability to escape from their empty, hopeless lives is all there is left. Both works can be considered masterpieces, particularly in displaying conformity and the lack of that personal drive to ever escape mediocrity, mainly because they seem to be more determined by the environment than they are capable of realizing. Ultimately, I had to pose a question: Are we all living our true, actual identities, freely and autonomously, or are we just like the Wheelers?
Ključne besede: domestic containment ideology, conformity, identity - social character, suburbanisation, consumerism - mass culture, quest for authenticity, hopeless emptiness
Objavljeno: 23.03.2016; Ogledov: 799; Prenosov: 64
.pdf Celotno besedilo (650,72 KB)

Determination of major phenolic acids, phenolic diterpenes and triterpenes in Rosemary (Rosmarinus Officinalis L.) by gas chromatography and mass spectrometry
Maša Islamčević Razboršek, Darinka Brodnjak-Vončina, Valter Doleček, Ernest Vončina, 2007, izvirni znanstveni članek

Opis: A gas chromatographic-mass spectrometric (GC-MS) method for the simultaneous identification and quantification of seven major phenolic and terpenic compounds in Rosmarinus officinalis L. was developed. The compounds were identified as trimethylsilyl (TMS) derivatives of phenolic acids (caffeic and rosmarinic acid), phenolic diterpene (carnosic acid), and pentacyclic triterpenes (ursolic, oleanolic, betulinic acid and betulin). These compounds have been identified by retention time and comparison of mass spectra. The procedure involves ultrasonic extraction using solvent mixture of tetrahydrofuran and ethanol. Extracts were fractionated by size exclusion chromatography (SEC) after purifying on graphitised carbon. The fraction with phenolic and terpenic compounds was derivatised prior to GC-MS analysis using N-methyl-N-trimethylsilyl trifluoroacetamide (MSTFA) as a derivatisation reagent. The derivatisation process was optimized regarding temperature and reaction time. The linearity of the method was tested in concentration range 4-25 mg L$^{–1}$. The correlation coefficients ($r^2$) were in the range of 0.997 to 0.999. The average recoveries for all compounds ranged from 80 to 82%. The GC-MS technique is specific and sensitive, and can be used for simultaneous identification and determination of a wide range of phenolic and terpenic compounds in different plants even at trace levels.
Ključne besede: Rosmarinus officinalis, diterpenes, triterpenes, size exclusion chromatography, gas chromatography, mass spectrometry
Objavljeno: 21.12.2015; Ogledov: 1085; Prenosov: 84
.pdf Celotno besedilo (227,83 KB)
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