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1.
Nevtropenični enterocolitis, povzročen s tirostatikom - poročilo o primeru
Vojko Flis, Marjan Skalicky, Nina Kobilica, Andrej Bergauer, 2010, strokovni članek

Opis: Nevtropenični enterocolitis, povzročen s tirostatikom
Ključne besede: neutropenic enterocolitis, adverse drug reactions, antithyroid drugs, surgery
Objavljeno: 10.07.2015; Ogledov: 537; Prenosov: 10
URL Celotno besedilo (0,00 KB)

2.
An overview of self-treatment and selfmedication practices among Slovenian citizens
Mateja Smogavec, Nina Softič, Janko Kersnik, Zalika Klemenc-Ketiš, 2010, izvirni znanstveni članek

Opis: Background: The aim of this study was to acquire data related to the prevalence of self-medication use among inhabitants of Slovenia. We focused onthe use of different self-medication practices, reasons for their use, the groups that use them, and probable association with socioeconomic status of anindividual user. Methods: This is a cross-sectional study, based on anonymous questionnaires, mailed in April 2009 to one thousand randomly choseninhabitants in all regions of the Republic of Slovenia. Results: We got 41.0 % response rate. 51.0 % of the respondents have used some form of selftreatment in the previous year. 69.3 % used OTC drugs and 38.3 % prescription drugs for self-medication. 83.1 % of them got the drugs for self-medication from the pharmacist but 23.0 % of them got the drugs for self-medication from their friends and relatives. Several demographical characteristics of the respondents were statistically significantly associatedwith self-med-ication practices; thus women were more likely using OTC drugs, vitamins and minerals, and more likely buying them in pharmacies, as compared to men; students and active population were more likely to use OTCdrugs, also more likely buying them in pharmacies as compared to other population groups. Conclusions: The use of self-medication in Slovenia is veryhigh, but mainly in quite safe mode. Majority of medicines are bought in regulated pharmacies, where users can also get pharmaceutical care. Physicianshave to take into account self-medication in their patients, take a thorough self-medication history and make good use of each consultation by educating the patients on appropriate and safe use of prescribed and OTC medicines.
Ključne besede: family practice, cross-sectional study, prescription, prescription drugs, non-prescription drugs
Objavljeno: 27.03.2017; Ogledov: 306; Prenosov: 8
.pdf Celotno besedilo (440,72 KB)

3.
High-Perssure process design for polymer treatment and heat transfer enhancement
Gregor Kravanja, 2018, doktorska disertacija

Opis: The doctoral thesis presents the design of several high-pressure processes involving »green solvents« so-called supercritical fluids for the eco-friendly and sustainable production of new products with special characteristics, fewer toxic residues, and low energy consumption. The thesis is divided into three main parts: polymer processing and formulation of active drugs, measurements of transport properties form pendant drop geometry, and study of heat transfer under supercritical conditions. In the first part, special attention is given to using biodegradable polymers in particle size reduction processes that are related to pharmaceutical applications for controlled drug release. The PGSSTM micronization process was applied to the biodegradable carrier materials polyoxyethylene stearyl ether (Brij 100 and Brij 50) and polyethylene glycol (PEG 4000) for the incorporation of the insoluble drugs nimodipine, fenofibrate, o-vanillin, and esomeprazole with the purpose of improving their bioavailability and dissolution rate. In order to optimize and design micronization process, preliminary transfer and thermodynamic experiments of water-soluble carriers (Brij and PEG)/ SCFs system were carried out. It was observed that a combination of process parameters, including particle size reduction and interactions between drugs and hydrophilic carriers, contributed to enhancing the dissolution rates of precipitated solid particles. In the second part, a new optimized experimental setup based on pendant drop tensiometry was developed and a mathematical model designed to fit the experimental data was used to determine the diffusion coefficients of binary systems at elevated pressures and temperatures. Droplet geometry was examined by using a precise computer algorithm that fits the Young–Laplace equation to the axisymmetric shape of a drop. The experimental procedure was validated by a comparison of the experimental data for the water-CO2 mixture with data from the literature. For the first time, interfacial tension of CO2 saturated solution with propylene glycol and diffusion coefficients of propylene glycol in supercritical CO2 at temperatures of 120°C and 150°C in a pressure range from 5 MPa, up to 17.5 MPa were measured. Additionally, the drop tensiometry method was applied for measuring systems that are of great importance in carbon sequestration related applications. The effect of argon as a co-contaminant in a CO2 stream on the interfacial tension, diffusion coefficients, and storage capacity was studied. In the third part, comprehensive investigation into the heat transfer performance of CO2, ethane and their azeotropic mixture at high pressures and temperatures was studied. A double pipe heat exchanger was developed and set up to study the effects of different operating parameters on heat transfer performance over a wide range of temperatures (25 °C to 90 °C) and pressures (5 MPa to 30 MPa). Heat flux of supercritical fluids was measured in the inner pipe in the counter-current with water in the outer pipe. For the first time, the heat transfer coefficients (HTC) of supercritical CO2, ethane and their azeotropic mixture in water loop have been measured and compared. A brief evaluation is provided of the effect of mass flux, heat flux, pressure, temperature and buoyancy force on heat transfer coefficients. Additionally, to properly evaluate the potential and the performance of azeotropic mixture CO2-ethane, the coefficients of performance (COP) were calculated for the heat pump working cycle and compared to a system containing exclusively CO2.
Ključne besede: supercritical fluids, PGSSTM, formulation of active drugs, biodegradable polymers, transport and thermodynamic data, pendant drop method, carbon sequestration, heat transfer coefficients
Objavljeno: 28.05.2018; Ogledov: 157; Prenosov: 38
.pdf Celotno besedilo (5,51 MB)

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