Phase equilibria of vanillins in compressed gasesŽeljko Knez
, Mojca Škerget
, Amra Perva-Uzunalić
, 2007, izvirni znanstveni članek
Opis: Solid-liquid phase transitions of vanillin, ethylvanillin, o-vanillin and o-ethylvanillin in compressed hydrocarbons (isobutane and propane), fluorinated hydrocarbons (R23, R134a and R236fa) and sulphur hexafluoride (SF6) were determined with a modified capillary method in a pressure range between 0.1 and 31.0 MPa. Equilibrium solubilities of vanillins in compressed fluorinated hydrocarbons were determined at temperatures 313.2 and 333.2 K and over a pressure range between 1.1 and 26.0 MPa with a static-analytic method. Experimental solubility data were correlated by a density-based Chrastil model. Results showed that phase equilibria of vanillins in investigated compressed gases are influenced by the type of alchoxy group (methoxy or ethoxy) and the position of OH group (ortho or para), bound to the aromatic ring of solute, as well as the molecular structure of the gas. Three phase SLG curves in p,T-projections mainly exhibited temperature minimums and negative slopes dp/dT, with a maximum melting point depression between 9 and 21 K; all systems with SF6 exhibited a continuous positive slope dp/dT of approximately 4.5 MPa/K. SLG curves with a temperature maximum at low pressure were observed for systems of o-vanillins with R23. Solubilities of o-vanillins in R23 and R236fa were higher in comparison with p-vanillins, whereas, in the case of R134a, the solubilities were influenced by the alchoxy group bound on aromatic ring: vanillin and o-vanillin with methoxy group are more soluble than vanillins with ethoxy group (ethylvanillin and o-ethylvanillin). The highest solubility of all four vanillins was observed in R236fa.
Ključne besede: solid-liquid-gas equilibria, melting point depression, solubility, vanilin isomers, hydrocarbons, fluorinated hydrocarbons, SF6
Objavljeno: 31.05.2012; Ogledov: 974; Prenosov: 24
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Comorbidities and characteristics of coronary heart disease patients: their impact on health-related quality of lifeKsenija Tušek-Bunc
, Davorina Petek
, 2016, izvirni znanstveni članek
Opis: Background: Patients with coronary heart disease (CHD) commonly present with more than one comorbid condition, contributing to poorer health-related quality of life (HRQoL). The aim of our study was to identify the associations between HRQoL and patient characteristics, vascular comorbidities and anxiety/depression disorders.
Methods: This observational study was conducted in 36 family medicine practices selected by random stratified sampling from all regions of Slovenia. HRQoL was assessed using the European Quality of Life - 5 Dimensions (EQ-5D) questionnaire and EQ Visual Analogue Scale (EQ-VAS). The associations between HRQoL and patient characteristics stratified by demographics, vascular comorbidities, health services used, their assessment of chronic illness care, and anxiety/depression disorders were identified by ordinal logistic regression and linear regression models.
Results: The final sample included 423 CHD patients with a mean age of 68.0 ± SD 10.8 years; 35.2% were female. Mean EQ-VAS score was 58.6 ± SD 19.9 (median: 60 with interquartile range of 45–75), and mean EQ-5D index was 0.60 ± SD 0.19 (median: 0.56 with interquartile range of 0.41–0.76). The statistically significant predictors of a lower EQ-VAS score were higher family physician visit frequency, heart failure (HF) and anxiety/depression disorders (R² 0.240; F = 17.368; p < 0.001). The statistically significant predictor of better HRQoL, according to EQ-5D was higher patient education, whereas higher family physician visit frequency, HF and peripheral artery disease (PAD) were predictors of poorer HRQoL (Nagelkerke R 2 = 0.298; χ 2 = 148.151; p < 0.001).
Conclusions: Results of our study reveal that comorbid conditions (HF and PAD), family physician visit frequency and years in education are significant predictors of HRQoL in Slovenian CHD patients.
Ključne besede: coronary heart disease patient, health-related quality of life, vascular comorbidities, anxiety/depression disorders
Objavljeno: 29.06.2017; Ogledov: 285; Prenosov: 108
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Factors associated with health-related quality of life among university studentsZalika Klemenc-Ketiš
, Janko Kersnik
, Ksenija Eder
, Dušan Colarič
, 2011, izvirni znanstveni članek
Opis: Introduction: University students are subjected to different kinds of stressors, i.e.academic pressures, social issues and financial problems. This can affect their academic achievements and quality of life.
Objective: The aim of this study was to determine the health-related quality of life of university students, and how it is affected by the presence of chronic diseases, mental disorders comorbidity, and patterns of medical services' use.
Methods: This web-based study included a sample of 1,410 Slovenian university students. We used a self-administered questionnaire, containing a sheet with demographic data, Zung's self-assessment inventories about anxiety and depression, and EQ-5D questionnaire. The main outcome measures were scores on EQ-5D part and VAS part of the EQ-5D questionnaire.
Results: Independent factors associated with the health-related quality of life of university students, were the presence of chronic pain, the presence of depression and anxiety, need for urgent medical help and at least one visit to a clinical specialist in the past year. The independent factors associated with the health status of university students were the presence of chronic diseases, chronic pain, depression and anxiety, a visit to a clinical specialist, a need for urgent medical help and a visit to an emergency unit in the past year.
Conclusion: Health-related quality of life of university students can be seriously affected by the presence of mental disorders and chronic pain. Appropriate health-related measures should be adopted to achieve early recognition of worse health-related quality of life, the presence of mental disorders and other chronic conditions, and to enable their effective treatment.
Ključne besede: quality of life, students, chronic disease, pain, depression, anxiety
Objavljeno: 04.08.2017; Ogledov: 201; Prenosov: 106
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