Iskanje po katalogu digitalne knjižnice

Opis: The static and dynamic loading capacities of components depend on the stress level to which the material is exposed. The fatigue behavior of materials manufactured using additive technology is accompanied by a pronounced scatter between the number of cycles at the same stress level, which is significantly greater than the scatter from a material with the same chemical composition, e.g., AISI 316L, but produced by rolling or forging. An important reason lies in the fact that fatigue cracks are initiated almost always below the material surface of the loaded specimen. Thus, in the article, assuming that a crack will always initiate below the surface, we analyzed the fatigue behavior of specimens with the same bearing cross section but with a different number of bearing rods. With a larger number of rods, the circumference around the supporting part of the rods was 1.73 times larger. Thus, experimental fatigue of specimens with different sizes showed that the dynamic loading capacity of components with a smaller number of bars is significantly greater and can be monitored by individual stress levels. Although there are no significant differences in loading capacity under static and low-cycle loading of materials manufactured with additive technologies, in high-cycle fatigue it has been shown that the ratio between the circumference and the loading cross section of tensile-loaded rods plays an important role in the lifetime. This finding is important for setting a strategy for manufacturing components with additive technologies. It shows that a better dynamic loading capacity can be obtained with a larger loading cross section.
Ključne besede: AISI 316L stainless steel, additive manufacturing, FEM, high-cycle fatigue, fractography analysis
Objavljeno v DKUM: 25.11.2024; Ogledov: 0; Prenosov: 13
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Opis: We carry out qualitative analysis of a fourth-order tumor growth control model using ordinary differential equations. We show that the system has one positive equilibrium point, and its stability is independent of the feedback gain. Using a Lyapunov function method, we prove that there exist realistic parameter values for which the systems admit limit cycle oscillations due to a supercritical Hopf bifurcation. The time evolution of the state variables is also represented.
Ključne besede: bifurcation, cancer therapy, limit cycle, singular point, tumor therapy, tumor control
Objavljeno v DKUM: 12.08.2024; Ogledov: 73; Prenosov: 6
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Opis: We propose a detailed computational beta cell model that emphasizes the role of anaplerotic metabolism under glucose and glucose-glutamine stimulation. This model goes beyond the traditional focus on mitochondrial oxidative phosphorylation and ATP-sensitive K+ channels, highlighting the predominant generation of ATP from phosphoenolpyruvate in the vicinity of KATP channels. It also underlines the modulatory role of H2O2 as a signaling molecule in the first phase of glucose-stimulated insulin secretion. In the second phase, the model emphasizes the critical role of anaplerotic pathways, activated by glucose stimulation via pyruvate carboxylase and by glutamine via glutamate dehydrogenase. It particularly focuses on the production of NADPH and glutamate as key enhancers of insulin secretion. The predictions of the model are consistent with empirical data, highlighting the complex interplay of metabolic pathways and emphasizing the primary role of glucose and the facilitating role of glutamine in insulin secretion. By delineating these crucial metabolic pathways, the model provides valuable insights into potential therapeutic targets for diabetes.
Ključne besede: mathematical models, pancreatic beta cell, pyruvate-malate cycle
Objavljeno v DKUM: 06.06.2024; Ogledov: 162; Prenosov: 12
Celotno besedilo (5,53 MB)
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Opis: Hyperlipidemia is a common metabolic disorder in modern society and may precede hyperglycemia and diabetes by several years. Exactly how disorders of lipid and glucose metabolism are related is still a mystery in many respects. We analyze the effects of hyperlipidemia, particularly free fatty acids, on pancreatic beta cells and insulin secretion. We have developed a computational model to quantitatively estimate the effects of specific metabolic pathways on insulin secretion and to assess the effects of short- and long-term exposure of beta cells to elevated concentrations of free fatty acids. We show that the major trigger for insulin secretion is the anaplerotic pathway via the phosphoenolpyruvate cycle, which is affected by free fatty acids via uncoupling protein 2 and proton leak and is particularly destructive in long-term chronic exposure to free fatty acids, leading to increased insulin secretion at low blood glucose and inadequate insulin secretion at high blood glucose. This results in beta cells remaining highly active in the “resting” state at low glucose and being unable to respond to anaplerotic signals at high pyruvate levels, as is the case with high blood glucose. The observed fatty-acid-induced disruption of anaplerotic pathways makes sense in the context of the physiological role of insulin as one of the major anabolic hormones.
Ključne besede: diabetes, insulin secretion, lipids, PEP cycle, uncoupling proteins, mitochondrial dysfunction
Objavljeno v DKUM: 20.05.2024; Ogledov: 133; Prenosov: 10
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Opis: Plastic production and its end-of-life management pose a significant environmental footprint. The mitigation strategies of the plastic industry are comparatively attainable than the other hard-to-abate sector. However, the involvement of different stakeholders is needed. The life cycle analysis proposed in this study allocated the environmental footprint to stakeholders based on the game theory concept. It addresses the limitation of previous approaches that do not guarantee the stakeholders from different stages will participate in the initiatives with the lowest net environmental footprint due to the dissatisfaction or imbalance in the allocated unburdening footprint (benefit) and burdening footprint. The applicability of the proposed approach is demonstrated through a plastic recycling case study. An allocation of 82 % of environmental benefit to the producer, 14 % to the manufacturer, and 4 % to the user are suggested to achieve efficiency (lowest external interference) and stable cooperation (participation in recycling). This work serves as an initial assessment in demonstrating the integration of the game theory concept in environmental footprint allocation or Life Cycle Assessment.
Ključne besede: plastic production, environmental footprint, life cycle
Objavljeno v DKUM: 18.04.2024; Ogledov: 155; Prenosov: 5
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