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Development through movement - psychopedagogical analysis and psychomotor approaches
Herbert Zoglowek, Maria Aleksandrovich, 2016, pregledni znanstveni članek

Opis: This paper discusses psychomotor development in early childhood and consists of three parts. The first part is a brief historical overview of the theoretical description and analysis of movement. The second part gives an overview of the variety of movement therapies and activity methods, which are effective in kindergarten work. The third part of the paper is an attempt to analyse and to reflect on the authors' own practical experiences of psychomotor work in kindergartens in Poland and Norway.
Ključne besede: early childhood, motor development, movement analysis, psychomotor activity, Poland, Norway
Objavljeno: 21.09.2017; Ogledov: 244; Prenosov: 65
.pdf Celotno besedilo (588,56 KB)
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Global Entrepreneurship Monitor 2002: the Slovenian report
Miroslav Rebernik, Polona Tominc, Miroslav Glas, Viljem Pšeničny, končno poročilo o rezultatih raziskav

Ključne besede: Entrepreneurship, Business demography, Companies, Entrepreneurship ecosystem, Entrepreneurial Activity
Objavljeno: 18.01.2017; Ogledov: 728; Prenosov: 56
.pdf Celotno besedilo (2,50 MB)
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The influence of royal jelly and human interferon-alpha (HuIFN-[alpha]N3) on proliferation, glutathione level and lipid peroxidation in human colorectal adenocarcinoma cells in vitro
Bratko Filipič, Lidija Gradišnik, Klemen Rihar, Eugen Šooš, Adriana Pereyra Gonzales, Jana Potokar, 2015, izvirni znanstveni članek

Opis: Among royal jelly’s (RJ) various biological activities, its possible antitumour activity deserves particular attention. The purpose of this study was to investigate the influence of RJ, its bioactive component 10-hydroxy-2-decenoic acid (10- HDA), and human interferon-alpha (HuIFN-αN3) on the proliferation of human colorectal adenocarcinoma cells (CaCo- 2), and ascertain their effect on intracellular glutathione (GSH) level and lipid peroxidation. We studied the antiproliferative (AP) activity of RJ [(0.1 g/10 mL phosphate buffer saline (PBS)], HuIFN-αN3 (1000 I.U. mL-1), 10-HDA at 100.0 μmol L-1, and their different combinations, in the ratio 1:1, 1:2, and 2:1 on CaCo-2 cells. The GSH level was measured by glutathione assay. The lipid peroxidation was measured by malondialdehyde (MDA) assay. Single RJ had a low AP activity: 2.0 (0.5 mg mL-1). HuIFN-αN3 had an AP activity of 2.5 (208.33 I.U. mL-1), while 10-HDA had an AP activity of 1.5 (37.5 μmol mL-1). The highest AP activity of 3.8 was obtained when RJ and HuIFN-αN3 were applied at the ratio 2:1. In that combination the level of GSH was 24.9±2.4 nmol g-3 of proteins (vs. 70.2±3.2 nmol g-3 in the control) and the level of MDA was 72.3±3.1 nmol g-3 (vs. 23.6±9.1 nmol g-3 in the control). It is generally assumed that 10-HDA, an important constituent of RJ, together with HuIFN-αN3, is responsible for the inhibition of CaCo-2 cells proliferation in vitro. In our study, however, RJ and HuIFN-αN3 applied at 2:1 decreased the level of GSH the most and significantly increased lipid peroxidation via MDA in CaCo-2 cells. Future studies should show whether these GSH- and MDA-related activities of RJ, HuIFN-αN3, 10-HDA, and their combinations may decrease the tumorigenicity index and tumorigenic potential of various tumour cells in vitro.
Ključne besede: antiproliferative activity, antitumour activity, malondialddehyde, CaCo-2 cells, 10-hydroxy-2-decenoic acid
Objavljeno: 30.03.2017; Ogledov: 384; Prenosov: 36
.pdf Celotno besedilo (355,56 KB)
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Effect of peptides' binding on the antimicrobial activity and biocompatibility of ‎protein-based substrates ‎
Maja Kaisersberger Vincek, 2017, doktorska disertacija

Opis: This work reveals the effect of coupling approach (chemical by using carbodiimide chemistry ‎and grafting-to vs. grafting-from synthesis routes, and enzymatic by using transglutaminase) ‎of a hydrophilic ε-poly-L-lysine (εPL) and an amphiphilic oligo-acyl-lysyl (OAK) derivative (K-7α12-OH) to wool fibers and gelatine (GEL) macromolecules, respectively, and substrates ‎antibacterial activity against Gram-negative E. coli and Gram-positive S. aureus bacteria ‎after 1–24 h of exposure, as well as their cytotoxicity. Different spectroscopic (ultraviolet-‎visible, infrared, fluorescence and electron paramagnetic resonance) and separation ‎techniques (size-exclusion chromatography and capillary zone electrophoresis) as well as ‎zeta potential and potentiometric titration analysis, were performed to confirm the covalent ‎coupling of εPL/OAK, and to determine the amount and orientation of its immobilisation.‎ The highest and kinetically the fastest level of bacterial reduction was achieved with ‎wool/GEL functionalised with εPL/OAK by chemical grafting-to approach. This effect ‎correlated with both the highest grafting yield and conformationally the highly-flexible ‎(brush-like) orientation linkage of εPL/OAK, implicating on the highest amount of accessible ‎amino groups interacting with bacterial membrane. However, OAK`s amphipathic structure, ‎the cationic charge and the hydrophobic moieties, resulted to relatively high reduction of S. ‎aureus for grafting-from and the enzymatic coupling approaches using OAK-functionalised ‎GEL. ‎ The εPL/OAK-functionalised GEL did not induce toxicity in human osteoblast cells, even at ‎‎~25-fold higher concentration than bacterial minimum inhibitory (MIC) concentration of ‎εPL/OAK, supporting their potential usage in biomedical applications.‎ It was also shown that non-ionic surfactant adsorbs strongly onto the wool surface during ‎the process of washing, thereby blocking the functional sites of immobilized εPL and ‎decreases its antibacterial efficiency. ‎ ‎
Ključne besede: wool, gelatine, antimicrobial peptides, ε-poly-L-lysine, oligo-acyl-lysyl, grafting chemistry, ‎grafting approach, peptide orientation, antibacterial activity, cytotoxicity‎
Objavljeno: 17.08.2017; Ogledov: 696; Prenosov: 64
.pdf Celotno besedilo (3,98 MB)

Health beliefs and practices among Slovenian Roma and their response to febrile illnesses
Danica Rotar-Pavlič, Erika Zelko, Janko Kersnik, Verica Lolič, 2011, izvirni znanstveni članek

Opis: Introduction: When the Roma fell ill in the past, they used herbal home remedies to treat diseases. If the remedy failed to cure the illness, they called the local healer. Today, most Roma visit physicians. This study investigates health beliefs and practices held by the Roma people in Slovenia and their response to febrile illnesses. Methods: Field interviews using a semi-structured questionnaire were conducted in the vicinity of Kočevje. Sociodemographic data were gathered and recorded manually, and the interviews were tape recorded. Qualitative analysis was performed by three researchers. Special attention was paid to data validation. Results: The majority of Roma are not acquainted with thermometers and therefore do not use them. About onethird of the interviewees knew what the normal body temperature should be. Only 15% of the Roma population take their body temperature when they are feeling unwell. One-half visit their physicians. More than half of the population take paracetamol or aspirin when they feel feverish. More often, they resort to tea and emphasize the healing effect of sweating. Conclusion: The Roma beliefs and practices regarding health and fever are instructive and show how impoverished a narrow biomedical approach can be. Failure to use technical devices, such as thermometers, and lack of familiarity with the numerical values defining the border between normal and elevated body temperature, nonetheless do not mean that the Roma take inappropriate measuresin response to illness. Illnesses (including fever) can also be recognized without these tools and can be appropriately responded to by drinking teas, using compresses, and taking fever-reducing medications.
Ključne besede: Roma, illness, thermometer, fever, activity, doctor
Objavljeno: 05.04.2017; Ogledov: 363; Prenosov: 72
.pdf Celotno besedilo (236,53 KB)
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Activity-based management of logistic costs in a manufacturing company
Julijana Krajnc, Klavdij Logožar, Bojana Korošec, 2012, izvirni znanstveni članek

Opis: Both the transparent reporting of logistics costs and the related accounting of their cost drivers present a significant factor for the successful management of material flows and the related logistics activities in production companies. These costs, which are mainly reported as part of overhead (indirect) costs in such companies, usually remain hidden or are not explicitly visible when the traditional method of accounting is applied. The aim of this research is to create a model of activity-based accounting of logistics costs in a production company, and to test its efficiency in the disclosure of logistics costs compared with traditional cost accounting. The application of the model in a production company shows that an activity based approach discloses as much as 108% more logistics costs at the level of a group of products than the traditional cost accounting approach. Further, detailed information on logistics costs obtained in this way enables their more efficient management.
Ključne besede: logistic costs, activity-based costing, cost allocation, cost visibility, cost management
Objavljeno: 31.05.2017; Ogledov: 493; Prenosov: 64
.pdf Celotno besedilo (449,77 KB)
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Institutional determinants and entrepreneurial action
Katja Crnogaj, Barbara Bradač Hojnik, 2016, objavljeni znanstveni prispevek na konferenci

Opis: The paper examines the effect of specific institutional factors on entrepreneurial activity. In the course of the examination, we encounter various viewpoints regarding entrepreneurship and different needs of national politics. The research objective is to determine whether institutional factors influence early-stage entrepreneurial activity. There is a broad array of opinions on appropriate set of factors that influence the entrepreneurship processes, on ways of their influence and on differentiating between the developed and less developed countries. Therefore, we examined the defined research hypothesis in the light of 24 countries (Argentina, Belgium, Brazil, Chile, Columbia, Croatia, Denmark, Finland, France, Greece, Hungary, Island, Italy, Japan, Latvia, Netherlands, Norway, Peru, Russia, Slovenia, Spain, United Kingdom, Uruguay and USA), in the period between the years 2006 and 2010 (24 countries * 5 years = 120 observations). The data was obtained from Global Entrepreneurship Monitor (GEM) database and complemented with data from other international sources such as Heritage Foundation, among others. With econometrics business methods, we determined that greater economic freedom in the institutional context of a country affects the extension of productive entrepreneurship, while the individual's decision for the entrepreneurship is conditioned significantly by the prevailing cultural and social norms.
Ključne besede: entrepreneurship, entrepreneurial activity, institutional environment factors, entrepreneurship policy
Objavljeno: 04.07.2017; Ogledov: 223; Prenosov: 43
.pdf Celotno besedilo (465,13 KB)
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Use of non-conventional cell disruption method for extraction of proteins from black yeasts
Maja Čolnik, Mateja Primožič, Željko Knez, Maja Leitgeb, 2016, izvirni znanstveni članek

Opis: The influence of pressure and treatment time on cells disruption of different black yeasts and on activities of extracted proteins using supercritical carbon dioxide process was studied. The cells of three different black yeasts Phaeotheca triangularis, Trimatostroma salinum, and Wallemia ichthyophaga were exposed to supercritical carbon dioxide (SC $CO_2$) by varying pressure at fixed temperature (35°C). The black yeasts cell walls were disrupted, and the content of the cells was spilled into the liquid medium. The impact of SC $CO_2$ conditions on secretion of enzymes and proteins from black yeast cells suspension was studied. The residual activity of the enzymes cellulase, $beta$-glucosidase, $alpha$-amylase, and protease was studied by enzymatic assay. The viability of black yeast cells was determined by measuring the optical density of the cell suspension at 600 nm. The total protein concentration in the suspension was determined on UV–Vis spectrophotometer at 595 nm. The release of intracellular and extracellular products from black yeast cells was achieved. Also, the observation by an environmental scanning electron microscopy shows major morphological changes with SC $CO_2$-treated cells. The advantages of the proposed method are in a simple use, which is also possible for heat-sensitive materials on one hand and on the other hand integration of the extraction of enzymes and their use in biocatalytical reactions.
Ključne besede: P. triangularis, W. ichtyophaga, T. salinum, supercritical carbon dioxide, enzyme activity, cells
Objavljeno: 10.07.2017; Ogledov: 497; Prenosov: 217
.pdf Celotno besedilo (2,13 MB)
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Antibacterial and anticandidal activity of Tylosema esculentum (marama) extracts
Walter Chingwaru, Gyebi Duodu, Yolandi Van Zyl, Schoeman, Runner Majinda, Sam Yeboah, Jose Jackson, Petrina Kapewangolo, Kandawa-Shulz, Minnaar, Avrelija Cencič, 2011, izvirni znanstveni članek

Opis: Bean and tuber extracts of Tylosema esculentum (marama) – an African creeping plant – were obtained using ethanol, methanol and water. Based on information that T. esculentum is used traditionally for the treatment of various diseases, the antibacterial and anticandidal effects of tuber and bean extracts were investigated. The antimicrobial activity of the extracts was tested on methicillin-resistant Staphylococcus aureus (MRSA, ATCC 6538), Mycobacterium terrae (ATCC 15755), Corynebacterium diphtheriae (clinical) and Candida albicans (ATCC 2091). We performed the broth microdilution test for the determination of the minimum inhibitory concentration (MIC) and a method to determine survival of microorganisms after in vitro co-incubation with the highest concentrations of T. esculentum extracts, followed by assessment of colony counts. Ethanol and methanol (phenolic) bean extracts exhibited higher potency against bacteria and yeast than aqueous extracts. Marama bean seed coat crude ethanolic extract (MSCE) and seed coat polyphenolic fractions, especially soluble-bound fraction (MSCIB), were highly antimicrobial against M. terrae, C. diphtheriae and C. albicans. All marama bean polyphenolic fractions, namely cotyledon acidified methanol fraction (MCAM), seed coat acidified methanol fraction (MSCAM), cotyledon insoluble-bound fraction (MCIB), seed coat insoluble-bound fraction (MSCIB), cotyledon-free polyphenolic fraction (MCFP) and seed coat free polyphenolic fraction (MSCFP) had high antimicrobial effects as shown by low respective MIC values between 0.1 mg/mL and 1 mg/mL. These MIC values were comparable to those of control antimicrobials used: amphotericin B (0.5 mg/mL) and cesfulodin (0.1 mg/mL) against C. diphtheriae, streptomycin (1.0 mg/mL) and gentamicin (0.4 mg/mL) against M. terrae, and amphotericin B (0.05 mg/mL) against C. albicans. Marama seed coat soluble-esterified fraction (MSCS) had closer activity to that of cefsulodin against M. terrae. High amounts of phenolic substances, such as gallic acid, especially in the seed coats, as well as high amounts of phytosterols, lignans, certain fatty acids and peptides (specifically protease inhibitors) in the cotyledons contributed to the observed antibacterial and anticandidal activities. Marama extracts, especially phenolic and crude seed coat extracts, had high multi-species antibacterial and anticandidal activities at concentrations comparable to that of some conventional drugs; these extracts have potential use as microbicides.
Ključne besede: marama, Tylosema esculentum, antibacterial activity, anticandidal activity
Objavljeno: 07.08.2017; Ogledov: 358; Prenosov: 165
.pdf Celotno besedilo (1,38 MB)
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Physical activity among nursing students
Leona Cilar, Nina Preložnik, Gregor Štiglic, Dominika Vrbnjak, Majda Pajnkihar, 2017, izvirni znanstveni članek

Opis: Introduction: Nurses need to encourage patients to lead a healthy lifestyle, hence it is important that as nursing students they are already aware of the importance of physical activity. The purpose of the study was to investigate the physical activities of nursing students. Aim: The aim of the study was to find out in what state physical activity of nursing students is and to find out what are their main reasons for lack of physical activity. Material and methods: We conducted a cross-sectional observational study using a mixed methods design. The quantitative data was collected using the survey method with a convenience sample of 123 students and used descriptive and inferential statistics for the analysis. For the qualitative data we used a Grounded Theory Method with semi-structured interviews on purposive samples of four students. Results and conclusions: In the quantitative part of this study we found a significantly higher proportion of outdoor physical activity in comparison to indoor physical activity (p < 0.001). The qualitative part contains the main categories of physical activity implementation, as well as three sub-categories: attitude to physical activity, barriers and incentives. Nursing students do not do physical activities regularly due to lack of time, obligations at the university, time of the year and finances.
Ključne besede: physical activity, nursing students, mental well-being, physical well-being
Objavljeno: 09.08.2017; Ogledov: 728; Prenosov: 244
.pdf Celotno besedilo (339,82 KB)
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