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Opis: Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine and is commonly used as an antifibrinolytic agent in large joint surgery, such as knee arthroplasty, to minimize blood loss and its associated complications. Some studies have suggested that perioperative intravenous TXA application lowers the incidence of postoperative infections after hip and knee arthroplasty. While its effects on bacteria are not its primary purpose, more research is needed further to elucidate the extent of TXA’s impact on bacterial inhibition and its clinical relevance. In order to determine possible inhibitory effects, 22 clinically relevant bacterial strains were exposed to different TXA concentrations. Two different assays were performed: a microdilution assay with traditional endpoint measurements and a kinetic growth assay for a time-dependent susceptibility assessment. With the microdilution technique, a growth inhibitory effect became evident at higher TXA concentrations (50 and 100 mg/mL) on eight tested bacterial strains, of which four demonstrated absence of growth at 100 mg/mL, suggesting minimal inhibitory concentration. However, the kinetic growth assay revealed more specific TXA-induced dynamic changes in the bacterial growth of all tested bacterial strains. This study showed that TXA affects the growth dynamics of bacteria by altering their lag phase duration, exponential growth rate, and population density and may contribute to the prevention of implant-associated infections.
Ključne besede: tranexamic acid, bacterial growth, antimicrobial effect, topical administration, arthroplasty
Objavljeno v DKUM: 19.04.2024; Ogledov: 155; Prenosov: 7
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Opis: Purpose: The article provides an in-depth analysis of the regulation of financial investigations under the Financial Administration Act (“Zakon o finančni upravi (ZFU)”, 2014) and the manner of implementing the regulatory framework of this instrument in Slovenia. It presents the conditions for the initiation of a financial investigation, along with the competence and authorisations of investigators, the status of a person under investigation, and the procedure and conclusion of a financial investigation. In the article we take the position that either the existing regulatory framework or the manner in which the regulatory framework of financial investigation is implemented is unconstitutional. Design/Methods/Approach: We applied the normative method, the analysis and synthesis method, and a case study. Findings: We claim that Article 100 of the “ZFU” (2014), which governs financial investigations, is not compliant with the Constitution or the manner in which this provision is implemented by the Financial Administration of the Republic of Slovenia, which also has support in courts’ decisions. The Financial Administration, the Administrative Court and courts of general jurisdiction interpret and implement Article 100 of the “ZFU”, in the section relating to the moment in which a financial investigation is completed and tax inspection proceedings begin, in a way that is not compliant with the explanation by the Constitutional Court of the Republic of Slovenia in decision No. U-I-69/22-4. Research Limitations/Implications: The research does not include a comparative analysis, i.e., an analysis of the regulation and practice of conducting financial investigations pertaining to infringements of tax regulations in other countries.
Ključne besede: Financial Administration Act, financial investigations, financial administration, constitution
Objavljeno v DKUM: 27.01.2023; Ogledov: 535; Prenosov: 19
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Opis: The Slovene public administration is part of the broader social system, therefore it must be responsive and proactive. The instrument of complaint in the administrative procedure, and wider in the context of the entire administrative management, is very helpful to public administration for tracking social changes and should therefore be seen as a form of constructive criticism. On the basis of user complaints regarding its services or the parties to the administrative procedure, the public administration must learn permanently and, as learning organisation, must incorporate its findings into future practice. The starting point of this contribution is the problems of the complaint in the narrow sense - customer dissatisfaction with the functioning of the public administration or arising from the fact that one of the characteristics of the administrative procedure or other services is the direct contact between the customer and the provider of the service. With this approach, the public administration will develop part of an integral system of quality and excellence that underlines the meaning of satisfaction of (all) the users of public services.
Ključne besede: public administration, administrative procedure, administrative management, complaint, Slovenia, customers
Objavljeno v DKUM: 22.01.2018; Ogledov: 1363; Prenosov: 426
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Opis: This paper presents the results of a study that investigated the attitudes of civil servants in public administration units in Slovenia regarding corruption at work. The results show that civil servants employed in public administration units take corruption seriously. The employees' perceptions of corruption and their willingness to report the offender are closely connected to their opinion on how others - their colleagues - perceive it (i.e., how serious they find corruption and whether they are willing to report the offender). There are important gender differences regarding the perceptions of corruption, as well as differences in the function they have and their membership in organizational units. The authors conclude that it is necessary to develop and strengthen the feelings of the employees' security and increase the link between perceiving corruption and one's own judgment of the seriousness of corruptive behaviour, as well as to decrease the tolerance regarding corruption.
Ključne besede: administrative corruption, corruptive behaviour, code of silence, anticorruptive measures, offender, management, civil servant, public administration unit
Objavljeno v DKUM: 29.11.2017; Ogledov: 1176; Prenosov: 362
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Opis: The main purpose of this paper is to examine how employeesʼ personal ethics, expressed through their personal values and attitudes toward social and environmental issues, are associated with the ethics of organizations in public administration. The authors introduce their own theoretical model that examines the relations between employeesʼ personal ethics - expressed through employeesʼ personal values and attitudes toward natural and social environments - and the ethics of public administration. The reported study examined these relations and tested a proposed model based on the answers of 212 employees from public administration organizations in Slovenia. Employeesʼ attitudes toward natural and social environments and the ethics of their organizations were measured using a questionnaire designed to measure aspects of ethics whereas personal values were measured using the Schwartz value survey. The results demonstrated that employeesʼ self-enhancing values significantly influence their attitudes toward the natural environment. Employeesʼ self-transcendence and self-enhancement values significantly influence their attitudes toward the social environment and the ethics of organizations. In addition, research results about the mediation effect of employeesʼ attitudes toward natural and social environments on the association between the employeesʼ personal values and their perception of the ethics of public administration organizations reveals that employeesʼ social attitudes have a significant impact on the ethics of public administration while the impact of self-transcending and self-enhancing values becomes insignificant. Based on results of testing our model we can conclude that the employeeʼs attitudes toward to the social environment represent a significantly more powerful predictor of ethics in public administration organizations than the employeesʼ personal values. These results present a solid basis for further theoretical and practical advancement of public administration ethics.
Ključne besede: attitudes, ethics, natural environment, public administration, Slovenia, social environment, values
Objavljeno v DKUM: 14.07.2017; Ogledov: 1367; Prenosov: 452
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