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1.
Ergonomsko oblikovanje delovnega mesta na preoblikovalnem stroju : diplomsko delo
Luka Šatan, 2021, diplomsko delo

Opis: V sklopu diplomske naloge je bil cilj doseči ergonomsko oblikovano delovno mesto na preoblikovalnem stroju za točno določen primer. Prvotno je bilo potrebno na delovnem mestu opraviti vse meritve, na osnovi katerih smo lahko s pomočjo metode OWAS, programskim paketom Jack, ter z različnimi preračuni preverjali obremenitve na zaposlenih. Na podlagi rezultatov smo lahko kasneje poiskali rešitve, katere so lahko kompleksne ali enostavne in s katerimi dosežemo ergonomsko oblikovano delovno mesto. Menim, da lahko podjetja z natančnimi pregledi delovnih mest, kasneje s pomočjo enostavnih rešitev oblikuje ergonomska delovna mesta, prav tako pa verjamem in upam, da bodo podjetja v prihodnosti čim bolj strmela k temu, saj s tem izboljšujejo kakovost dela in zadovoljstvo med zaposlenimi (skrb za njihovo zdravje in dobro počutje).
Ključne besede: ergonomija, obremenitve, delovno mesto, OWAS, Programski paket Jack
Objavljeno v DKUM: 29.09.2021; Ogledov: 306; Prenosov: 53
.pdf Celotno besedilo (3,10 MB)

2.
Primerjava meritev osvetljenosti s pametnim telefonom in klasičnim luxmetrom : diplomsko delo
Pavel Dobaj, 2021, diplomsko delo

Opis: V sklopu diplomske naloge nas je zanimalo, ali lahko primerjamo natančnost meritev osvetljenosti s pametnim telefonom in klasičnim luxmetrom. Meritve smo izvajali s telefoni z dvema različnima operacijskima sistemoma (Android in iOS), za katera so predstavljene tudi razlike pri merjenju osvetljenosti. V nalogi so predstavljene ugotovitve, od česa vsega je odvisna točnost meritev osvetljenosti. Trdimo lahko, da so pametni telefoni nezanesljivi za merjenje osvetljenosti tam, kjer je potrebna visoka natančnost meritev. Kdaj bomo lahko merili natančno osvetljenost s pametnimi telefoni v različnih pogojih, pa je vprašanje časa in interesa.
Ključne besede: osvetljenost, pametni telefon, mobilna aplikacija, meritve osvetljenosti
Objavljeno v DKUM: 07.09.2021; Ogledov: 380; Prenosov: 29
.pdf Celotno besedilo (1,33 MB)

3.
Guanosine quadruplexes in solution : a small-angle X-ray scattering analysis of temperature effects on self-assembling of deoxyguanosine monophosphate
Paolo Mariani, Francesco Spinozzi, Francesco Federiconi, M. G. Ortore, Heinz Amenitsch, Lea Spindler, Irena Drevenšek Olenik, 2010, izvirni znanstveni članek

Opis: We investigated quadruplex formation in aqueous solutions of -deoxyriboguanosine -monophosphate, d(pG), which takes place in the absence of the covalent axial backbone. A series of in-solution small angle X-ray scattering experiments on d(pG) have been performed as a function of temperature in the absence of excess salt, at a concentration just above the critical one at which self-assembling occurs. A global fit approach has been used to derive composition and size distribution of the scattering particles as a function of temperature. The obtained results give thermodynamical justification for the observed phase-behavior, indicating that octamer formation is essential for quadruplex elongation. Our investigation shows that d(pG) quadruplexes are very suitable to assess the potential of G-quadruplex formation and to study the self-assembling thermodynamics.
Ključne besede: G-quadruplexes, guanosine
Objavljeno v DKUM: 14.06.2017; Ogledov: 583; Prenosov: 125
.pdf Celotno besedilo (4,23 MB)
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4.
Effect of base sequence on G-wire formation in solution
Lea Spindler, Martin Rigler, Irena Drevenšek Olenik, Mateus Webba da Silva, Nason Ma'ani Hessari, 2010, izvirni znanstveni članek

Opis: The formation and dimensions of G-wires by different short G-rich DNA sequences in solution were investigated by dynamic light scattering (DLS) and polyacrilamide gel electrophoresis (PAGE). To explore the basic principles of wire formation, we studied the effects of base sequence, method of preparation, temperature, and oligonucleotide concentration. Both DLS and PAGE show that thermal annealing induces much less macromolecular self-assembly than dialysis. The degree of assembly and consequently length of G-wires (5-6 nm) are well resolved by both methods for DNA sequences with intermediate length, while some discrepancies appear for the shortest and longest sequences. As expected, the longest DNA sequence gives the longest macromolecular aggregates with a length of about 11 nm as estimated by DLS. The quadruplex topologies show no concentration dependence in the investigated DNA concentration range (0.1 mM–0.4 mM) and no structural change upon heating.
Ključne besede: DNA, dynamic light scattering, DLS, polyacrylamide gel electrophoresis, PAGE, genetics
Objavljeno v DKUM: 14.06.2017; Ogledov: 999; Prenosov: 333
.pdf Celotno besedilo (3,34 MB)
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5.
Vpliv hrupa na proizvodni in izobraževalni proces
Sabina Hrašan, 2016, magistrsko delo

Opis: Hrup kot nezaželena oblika zvoka postaja vedno večji onesnaževalec našega okolja. To delo obravnava vpliv hrupa v dveh različnih okoljih: v proizvodnji (podjetje Alba d. o. o.) in v pedagoški dejavnosti (Srednja šola Ravne). V obeh okoljih so bile izvedene meritve hrupa in njihova frekvenčna analiza. Meritve so pokazale, da raven hrupa nikjer ne presega zakonsko določenih vrednosti, razen v delavnicah, kjer je bilo prisotno brušenje, udarjanje s kladivom, rezkanje, delo s stroji in v mizarski delavnici. V teh okoljih je zato nujno delavcem zagotoviti ustrezno osebno varovalno zaščito. Frekvenčna analiza hrupa je opozorila na zelo škodljiv nizkofrekvenčni hrup ali infrazvok, ki so ga meritve zaznale v industriji, v razredu pa ne. Zaposleni so izpolnili tudi anketni vprašalnik, na osnovi katerega je bilo postavljenih 6 hipotez. S statistično analizo anketnih odgovorov so bile potrjene naslednje hipoteze: a) v največji meri vpliva hrup na učitelje tako, da občutijo nervozo; b) več proizvodnih delavcev kot učiteljev pozna sodelavce, ki slabo slišijo; c) bolj pogosto se hrup pojavlja med proizvodnimi delavci kot učitelji; d) obstajajo statistično značilne razlike v zdravstvenih težavah med učitelji, ki delajo v okolju, kjer se vsakodnevno pojavlja hrup in učitelji, ki delajo v okolju kjer se občasno pojavlja hrup. Ovrženi sta bili dve hipotezi: a) več kot 50% delavcev je mnenja, da ima težave s sluhom, ter b) učitelji so po prihodu iz službe raje v tišini kot proizvodni delavci. Rezultati izvedene raziskave potrjujejo, da hrup vzbuja nemir, deluje stresno, vpliva na človekovo zdravje in njegovo počutje in ker je vsak dan na milijone delavcev v Evropi izpostavljenih hrupu pri delu in tveganjem, ki jih ta lahko povzroči, bi tej problematiki morali v prihodnje posvetiti več pozornosti in raziskav.
Ključne besede: hrup, obremenitev hrupa, ekvivalentna raven, frekvenčna analiza, avralni in ekstraavralni škodljivi učinki hrupa, infrazvok, stres, zdravstvene težave, osebna varovalna oprema, naglušnost, ..
Objavljeno v DKUM: 02.09.2016; Ogledov: 1465; Prenosov: 198
.pdf Celotno besedilo (2,11 MB)

6.
Prehospital hyperoxemia does not influence the functional neurological outcome in polytraumatized patients with traumatic head injury
Vitka Vujanović, Tine Pelcl, Mateja Špindler, Zalika Klemenc-Ketiš, Matej Strnad, 2013, objavljeni povzetek znanstvenega prispevka na konferenci

Opis: Introduction: The association between hyperoxemia and neurological outcome in trauma patients is not clear. We examined the association between prehospital hyperoxemia and neurological outcome in polytraumatized patients. Methods: This was a retrospective study of polytraumatized patients with traumatic head injury who were endotracheal intubated and ventilated with supplemental oxygen (100%) in the prehospital emergency setting. Arterial partial oxygen pressure (PaO2) was measured after the arrival to the hospital trauma center. We included the patients with initial PaO2 above 160 mmHg (hyperoxemia group). The severity of the trauma was determined upon the admission to the hospital by injury severity scale (ISS) and the outcome was assessed at the discharge from the hospital using Glasgow coma scale (GCS), Glasgow outcome scale (GOS) and Cerebral performance categories scale (CPC). Mann-Whitney's test was used for data analysis. Results: Sixty patients were involved in the study. Forty-eight (80%) of them were men and 86.7% sustained blunt trauma. Hyperoxemia was present in 41.6% of patients. Initial average ISS was 38, in patients with normoxemia 32.5 and in patients with hyperoxemia 35.4. Discharge GCS, GOS and CPC in hyperoxemia group compared to normoxemia group were 9.86 vs. 9.33 (p=0.503), 2.52 vs. 2.24 (p=0.613) and 3.10 vs. 3.19 (p=0.936) with the duration of hospitalization of 26.64 days vs. 27.72 days (p=0.984). Conclusions: Prehospital hyperoxemia did not influence the functional neurological outcome. One of the reasons for this finding could be short arrival time to the trauma center where repeated analysis of arterial blood gases were performed. Therefore, correction of fraction of inspired oxygen according to the arterial blood gases analysis shorten the time of hyperoxemia thus reduced neuronal brain damage. References: Beynon et al. Brain tissue oxygen monitoring and hyperoxic treatment in patients with traumatic brain injury. J Neurotrauma 2012;29:2109-23. Brenner et al. Association between early hyperoxia and worse outcomes after traumatic brain injury. Arch Surg. 2012; 16:1-5. Davis et al. Both hypoxemia and extreme hyperoxemia may be detrimental in patients with severe traumatic brain injury. J Neurotrauma 2009;26:2217-23.
Ključne besede: poškodba glave, nujna medicina
Objavljeno v DKUM: 10.07.2015; Ogledov: 1233; Prenosov: 90
URL Povezava na celotno besedilo

7.
Disodium guanosine 5'-monophosphate self-associates into nanoscale cylinders at pH 8: a combined diffusion NMR spectroscopy and dynamic light scattering study
Alan Wong, Ida Ramsey, Lea Spindler, Gang Wu, 2005, izvirni znanstveni članek

Opis: We report a combined NMR and dynamic light scattering (DLS) study on the size of supramolecular structures formed by disodium guanosine 5'-monophosphate, Na2(5'-GMP), at pH 8. In general, two distinct types of aggregate species are present in an aqueous solution of Na2(5'-GMP). One type consists of stacking 5'-GMP monomers, and the other contains stacking G-quartets. Both types of aggregates can be modeled as rodlike cylinders. The cylinder diameter is 10 and 26 A for monomer aggregates and quartet aggregates, respectively. For Na2(5'-GMP) concentrations between 18 and 34 wt %, the cylinders formed by stacking G-quartets have an average length between 8 and 30 nm, corresponding to a stack of ~24-87 G-quartets. These nanoscale aggregates are significantly larger than what had previously been believed for Na2(5'-GMP) self-associationat pH 8. The length of both types of 5'-GMP aggregates was found to increase with Na2(5ć-GMP) concentration but was insensitive to the added NaCl in solution. While the aggregate size for monomer aggregates increases with a decrease in temperature, the size of G-quartet aggregates is essentially independent of temperature. We found that the size of G-quartet aggregates is slightly larger in D2O than in H2O, whereas the size of monomer aggregates remains the same in D2O and in H2O. We observed a linear relationship between the axial ratio of the 5ć-GMP cylinders and the Na2(5'-GMP) concentration for both types of 5ć-GMP aggregates, which suggests a common stacking mechanism for monomers and G-quartets.
Objavljeno v DKUM: 01.06.2012; Ogledov: 1069; Prenosov: 80
URL Povezava na celotno besedilo

8.
G-Quadruplex Nucleic Acids : editorial
Ramon Eritja, Jean-Louis Mergny, Daniela Montesarchio, Lea Spindler, Mateus Webba da Silva, 2010, predgovor, spremna beseda

Ključne besede: G-quadruplexes, guanosine, oligonucleotides
Objavljeno v DKUM: 31.05.2012; Ogledov: 2051; Prenosov: 139
.pdf Celotno besedilo (1,03 MB)
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9.
G-Quadruplex Nucleic Acids
2010, znanstvena monografija

Ključne besede: G-quadruplexes, guanosine, oligonucleotides
Objavljeno v DKUM: 31.05.2012; Ogledov: 1132; Prenosov: 100
URL Povezava na celotno besedilo

10.
RAZVOJ NAMIZNIH APLIKACIJ V WPF Z ARHITEKTURNIM VZORCEM MVVM IN OGRODJEM MEF
Matej Spindler, 2011, diplomsko delo/naloga

Opis: V diplomskem delu je predstavljena tehnologija Windows Presentation Foundation, ki je namenjena razvoju aplikacij z bogatim uporabniškim vmesnikom. Za boljši in lažji razvoj pa bomo spoznali tudi arhitekturen vzorec Model-Pogled-Model Pogleda (ang. Model-View-View Model) in ogrodje za upravljanje razširitev (ang. Managed Extensibility Framework).
Ključne besede: MVVM, WPF, MEF, C#, načrtovalski vzorci, namizne aplikacije
Objavljeno v DKUM: 22.11.2011; Ogledov: 1904; Prenosov: 241
.pdf Celotno besedilo (1,96 MB)

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