Iskanje po katalogu digitalne knjižnice

Opis: Humans are frequently exposed to environmental hepatotoxins, which can lead to liver failure. Biosensors may be the best candidate for the detection of hepatotoxins because of their high sensitivity and specificity, convenience, time-saving, low cost, and extremely low detection limit. To investigate suitability of HepG2 cells for biosensor use, different methods of adhesion on stainless steel surfaces were investigated, with three groups of experiments performed in vitro. Cytotoxicity assays, which include the resazurin assay, the neutral red assay (NR), and the Coomassie Brilliant Blue (CBB) assay, were used to determine the viability of HepG2 cells exposed to various concentrations of aflatoxin B1 (AFB1) and isoniazid (INH) in parallel. The viability of the HepG2 cells on the stainless steel surface was quantitatively and qualitatively examined with different microscopy techniques. A simple cell-based electrochemical biosensor was developed by evaluating the viability of the HepG2 cells on the stainless steel surface when exposed to various concentrations of AFB1 and INH by using electrochemical impedance spectroscopy (EIS). The results showed that HepG2 cells can adhere to the metal surface and could be used as part of the biosensor to determine simple hepatotoxic samples.
Ključne besede: HepG2 cell line, impedance biosensor, adhesion, hepatotoxins, stainless steel
Objavljeno v DKUM: 10.04.2025; Ogledov: 0; Prenosov: 3
Celotno besedilo (1,87 MB)
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Opis: Vending machines in health and social care facilities are often the only possible choice for a quick snack for workers and visitors, in many cases providing unhealthy dietary choices. Our study aimed to analyse the variety and nutritional quality of foods available in vending machines placed in social and health care institution in Slovenia. The available snacks were quantitatively assessed, using traffic light profiling. The model used for nutrient profiling was that of the Food Standards Australia New Zealand (FSANZ). Vending machines in 188 institutions were surveyed, resulting in 5625 food-items consisting of 267 unique product labels. Sweet products dominate in vending machines offers (about 70%), while nuts and seeds (8.4%), yoghurts (2.1%), fruits (1.4%) and milk (0.3%) are present in a very small proportion or are not available at all. According to FSANZ, 88.5% of all displayed food items in vending machines can be considered as lower nutritional quality or less healthy products. The authors’ future activities will be focused on ensuring wider availability of healthy dietary choices and on including official guidelines in tender conditions for vending machines in health and social care institutions in Slovenia.
Ključne besede: snacks, vending machines, social care institutions, health care institutions, Slovenia
Objavljeno v DKUM: 10.03.2025; Ogledov: 0; Prenosov: 6
Celotno besedilo (802,53 KB)
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Opis: In this paper, the quality of the municipal waste sorting process in seven waste management centers in Slovenia was assessed using the qualitative multicriteria analysis (MCA) method DEX (Decision EXpert) implemented in DEXi software, which is based on multicriteria decomposition of the problem and utility functions in the form of ʺif-thenʺ decision rules. The study was based on eight types of secondary raw materials. The quality of the secondary raw materials, the regularity of the delivery of secondary raw materials to recycling units based on the sorting efficiency, and the loading weight of the individual baled fractions in the transport of secondary raw materials for recycling were the main parameters used in the model. The final assessment shows good waste management service in centers A and D. Centers B, C, and F were rated ʺaverageʺ. The ʺbadʺ rating was assigned to centers E and G.
Ključne besede: waste sorting, quality management, multicriteria decision analysis, expert system DEXi
Objavljeno v DKUM: 03.02.2025; Ogledov: 0; Prenosov: 4
Celotno besedilo (2,88 MB)
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Opis: Magistrsko delo podaja idejno rešitev za zasnovo centra za fizikalno medicino in rehabilitacijo, temeljenega na biofilični arhitekturi. Zasnova centra temelji na detajlni raziskavi in preučevanju literature ter ponuja premislek o možnostih tovrstnega oblikovanja in programa. Skozi raziskave biofilije, biofiličnega oblikovanja, biofiličnih elemetov in referenc, razvijamo in ustvarjamo idejo o oblikovanju in delovanju novega centra. Povezava biofilije in tovrstnega programa, ponuja in odpira možnost oblikovanja funkcionalnega objekta. Zasnova programa, temelji na pravilnikih in referenc že izvedenih centrov, na področju Medžimurske županije in Evrope. Na podlagi analiz širšega in ožjega območja, je izbrana lokacija za postavitev novega centra za fizikalno medicino in rehabilitacijo, ki omogoča povezavo z okolico in obstoječim kompleksom. Konceptulna rešitev izhaja iz prostora in prostorskih omejitev. Center je zasnovan kot povezava žive narave in grajenega okolja, kar omogoča zasnovo ugodnega bivalnega okolja, bivanje v neokrnjeni naravi v času okrevanja, hkrati pa pripomaga k programski pestrosti območja.
Ključne besede: fizikalna medicina, fizikalna rehabilitacija, biofilija, biofilična arhitektura, zelena fasada, zelena streha, vertikalna ozelenitev
Objavljeno v DKUM: 14.01.2025; Ogledov: 0; Prenosov: 97
Celotno besedilo (76,58 MB)

Opis: This thesis addresses the redevelopment of a centrally located site in Struga, currently occupied by a large, unadorned parking lot devoid of greenery. Surrounded by key state institutions, including the Health Insurance Office, Municipal Archives, and the Main Post Office, as well as public amenities, such as restaurants and pharmacies, the site offers a unique opportunity for urban revitalization.Until 2016, this location served as the central square of Struga. Following the restoration of the "Monument of Revolution," it was expected that the area would be transformed into a modern, attractive space for local residents. However, contrary to these expectations, it has since been repurposed as a parking lot. This project envisions reclaiming the site as a multifunctional space that serves as a cultural hub and social gathering point for both residents and visitors.Struga, situated on the shores of Lake Ohrid in the Republic of North Macedonia, has a population of approximately 50,000 and is a popular summer tourist destination. Despite this, the city faces a deficit of social gathering places and environments conducive to student collaboration and study. The existing city library, with its outdated facilities and limited collection of 8,000 books, fails to meet modern standards. Furthermore, Struga’s renowned Poetry Nights festival underscores the lack of dedicated public spaces for cultural events, highlighting the need for proper outdoor venues. The absence of adequate library resources and diverse social spaces for various age groups further exacerbates these challenges.This project proposes a comprehensive solution by transforming the parking lot into a multifaceted community facility. The envisioned development includes an open square for events, a gallery and exhibition hall, an innovative city library, study areas, communal spaces, green zones, and a children’s playground. Outdoor reading areas and organized play activities will be integrated into the design, promoting relaxation and leisure within an inviting, green environment.By combining diverse indoor and outdoor programs, the project seeks to foster social interaction across all age groups, enhancing community cohesion. This multi-generational event center and library will become a landmark for Struga, enriching the city’s cultural, recreational, and educational landscape while significantly improving the quality of life for its residents.
Ključne besede: contemporary architecture, library, multigeneration building, square, public space, common space, green space, Struga.
Objavljeno v DKUM: 13.01.2025; Ogledov: 0; Prenosov: 65
Celotno besedilo (94,06 MB)