1. Atherosclerosis, epigenetic modifications, and arterial stiffnessNejc Piko, Robert Ekart, Sebastjan Bevc, Radovan Hojs, 2017, review article Keywords: ateroskleroza, epigenetika, togost arterij
Published in DKUM: 09.04.2024; Views: 218; Downloads: 19
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2. Subendocardial viability, ambulatory blood pressure monitoring and serum biomarkers for cardiovascular disease in chronic kidney patientsNejc Piko, Tajda Šrot Volavc, Nina Vodošek Hojs, Sebastjan Bevc, Radovan Hojs, Robert Ekart, 2019, original scientific article Keywords: arterijska togost, augmentacijksi indeks, kronična ledvičnabolezen, NT-proBNP, razmerje subendokardne viabilnosti miokarda
Published in DKUM: 04.04.2024; Views: 195; Downloads: 4
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3. The role of oxidative stress in kidney injuryNejc Piko, Sebastjan Bevc, Radovan Hojs, Robert Ekart, 2023, review article Abstract: Acute kidney injury and chronic kidney disease are among the most common non-communicable diseases in the developed world, with increasing prevalence. Patients with acute kidney injury are at an increased risk of developing chronic kidney disease. One of kidney injury’s most common clinical sequelae is increased cardiovascular morbidity and mortality. In recent years, new insights into the pathophysiology of renal damage have been made. Oxidative stress is the imbalance favoring the increased generation of ROS and/or reduced body’s innate antioxidant defense mechanisms and is of pivotal importance, not only in the development and progression of kidney disease but also in understanding the enhanced cardiovascular risk in these patients. This article summarizes and emphasizes the role of oxidative stress in acute kidney injury, various forms of chronic kidney disease, and also in patients on renal replacement therapy (hemodialysis, peritoneal dialysis, and after kidney transplant). Additionally, the role of oxidative stress in the development of drug-related nephrotoxicity and also in the development after exposure to various environmental and occupational pollutants is presented.
Keywords: acute kidney injury, acute tubular necrosis, chronic kidney disease, oxidative stress, reactive oxygen species
Published in DKUM: 19.03.2024; Views: 210; Downloads: 32
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4. Analiza povezav med arterijsko togostjo, ekspresijskim profilom mikroRNK iz periferne krvi in stopnjo aterosklerotične prizadetosti koronarnih arterij pri bolnikih z normalnim ali zmanjšanim ledvičnim delovanjemNejc Piko, 2022, doctoral dissertation Abstract: Ateroskleroza je kronična vnetna bolezen arterij, ki vodi v zoženje svetline žil ter v ishemično okvaro tkiv in organov v povirju prizadetih arterij. Med srčnožilne bolezni uvrščamo ishemično bolezen srca, periferno arterijsko bolezen, bolezni možganskih žil ter anevrizme prsne in trebušne aorte. Predstavljajo enega izmed najpogostejših vzrokov umrljivosti v razvitem svetu in so neposredna posledica napredovale ateroskleroze. Kronična ledvična bolezen je pomemben dejavnik tveganja za srčnožilne bolezni. Arterijska togost označuje zmanjšano podajnost arterij in je povezana s strukturnimi in funkcionalnimi spremembami v žilni steni in pretoku krvi. MikroRNK so ključni epigenetski regulatorji številnih procesov v telesu in imajo velik potencial pri prepoznavanju in zdravljenju srčnožilnih bolezni.
V naši študiji smo analizirali povezave med koronarno arterijsko boleznijo, periferno arterijsko boleznijo in arterijsko togostjo pri bolnikih z in brez kronične ledvične bolezni. Prav tako smo analizirali ekspresijski profil mikroRNK molekul pri bolnikih z najvišjimi in najnižjimi vrednostmi hitrosti karotidno-femoralnega pulznega vala.
Rezultati naše študije dokazujejo, da imajo bolniki s kronično ledvično boleznijo višjo arterijsko togost ter nižji gleženjski indeks. Pri bolnikih s kronično ledvično boleznijo je bilo nekoliko več trožilne koronarne arterijske bolezni, vendar razlika v primerjavi z bolniki brez kronične ledvične bolezni ni bila statistično pomembna.
V ekspresiji mikroRNK razlik ni bilo.
Keywords: ateroskleroza, arterijska togost, kronična ledvična bolezen, srčnožilna bolezen, mikro RNK
Published in DKUM: 16.02.2023; Views: 568; Downloads: 80
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