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1.
Uvajanje novo zaposlenih diplomiranih medicinskih sester za delo s citostatiki
Natalija Berlič, 2025, magistrsko delo

Opis: Onkološka nega se razvija zaradi napredka zdravljenja raka. Medicinske sestre potrebujejo strokovna znanja za celovito obravnavo pacienta. Zaradi pomanjkanja kadra uvajalni programi niso vedno kakovostni, mentorji pa pogosto niso na voljo. Namen zaključnega dela je raziskati proces uvajanja novo zaposlenih medicinskih sester za delo s citostatiki. Metode: Uporabljena je bila kvalitativna metodologija in opisna metoda dela. Za zbiranje podatkov smo uporabili delno strukturiran intervju. V raziskavi je sodelovalo šest novo zaposlenih diplomiranih medicinskih sester. Analiza je bila opravljena z metodo tematske analize. Rezultati: V analizi smo izpostavili pet glavnih tem: »Uvajanje v delo s citostatiki, informacije in podpora med uvajanjem, izzivi in težave med uvajanjem, mentorstvo in program uvajanja v delo s citostatiki«. Ugotovili smo, da vsi navajajo dober uvajalni sistem razen pri mentorstvu, kjer bi želeli zmanjšati pogoste menjave mentorjev. Razprava in zaključek: Kljub zahtevnosti onkološkega področja, večanju števila obolelih ter pomanjkanju kadra je raziskan uvajalni program dobro zastavljen. Še zmeraj pa se najde prostor za izboljšave mentorskega programa.
Ključne besede: uvajanje, mentorstvo, novo zaposlene medicinske sestre, citostatiki, varnost
Objavljeno v DKUM: 22.05.2025; Ogledov: 0; Prenosov: 0
.pdf Celotno besedilo (462,65 KB)

2.
Priprava granuliranih gliničnih adsorbentov na pol-industrijskem nivoju : magistrsko delo
Ana Goričan, 2025, magistrsko delo

Opis: Uporaba različnih adsorpcijskih sredstev za sušenje komprimiranega zraka je ključnega pomena v številnih industrijskih panogah, saj zagotavlja stabilne pogoje za delovanje opreme in preprečuje korozijo. V magistrskem delu smo proučevali razvoj granulirane aktivirane glinice, namenjene uporabi v sušilnikih komprimiranega zraka. Cilj je bil proizvesti granulat iz aluminijevega hidrata, aktivirane glinice in psevdoboehmita v različnih razmerjih, z namenom doseganja čim višje trdote granul, specifične površine 300 m²/g, določene po BET metodi, in kapacitete vodne adsorpcije (SWA) 15 %. V raziskavi smo uporabili dve različni vrsti glinice in tri tipe hidratov, da bi proučili njihov vpliv na lastnosti granulata. Poleg vpliva surovin smo proučevali še vpliv kalcinacije pri različnih temperaturah. Rezultati so pokazali, da delež aluminijevega hidrata pomembno vpliva na trdoto granul. Nižji deleži hidrata so omogočili izdelavo trdnejših granul zaradi manjše poroznosti, medtem ko je dodatek psevdoboehmita izboljšal trdoto, specifično površino in adsorpcijske lastnosti. Najboljši rezultati so bili doseženi pri formulaciji s 35 % hidrata, kjer so granule dosegle najvišjo trdoto 51 N in SWA 13,3 %, kar se približuje zastavljenim ciljem, ter z 20 % hidrata, kjer je bila dosežena najvišja specifična površina, ki je znašala 283,05 m2/g. Optimizacija je pokazala, da kalcinacija pri temperaturah nad 400 °C ni smiselna, saj ne prinaša bistvenih izboljšav in povečuje energetske stroške. Opravljene so bile tudi XRD analize za boljši vpogled v strukturno sestavo končnih produktov. Ugotovljena sta bila prevlada amorfnih faz pri nižjih temperaturah in prehod v χ ter κ glinico pri višjih temperaturah. Čeprav cilji niso bili povsem doseženi, raziskava predstavlja pomemben vpogled v vpliv surovin in procesnih parametrov na lastnosti granulata. Naše ugotovitve ponujajo trdno osnovo za nadaljnje raziskave in izboljšave materialov za doseganje konkurenčnosti na trgu.
Ključne besede: aktivirana glinica, aluminijev hidrat, adsorbent, granuliranje, adsorpcija
Objavljeno v DKUM: 06.05.2025; Ogledov: 0; Prenosov: 0
.pdf Celotno besedilo (6,54 MB)

3.
Ranking as a procedure for selecting a replacement variable in the score predicting the survival of patients treated with curative intent for colorectal liver metastases
Irena Plahuta, Matej Mencinger, Iztok Peruš, Tomislav Magdalenić, Špela Turk, Aleks Brumec, Stojan Potrč, Arpad Ivanecz, 2023, izvirni znanstveni članek

Opis: Background and Objectives: The issue of a missing variable precludes the external validation of many prognostic models. For example, the Liverpool score predicts the survival of patients undergoing surgical therapy for colorectal liver metastases, but it includes the neutrophil–lymphocyte ratio, which cannot be measured retrospectively. Materials and Methods: We aimed to find the most appropriate replacement for the neutrophil–lymphocyte ratio. Survival analysis was performed on data representing 632 liver resections for colorectal liver metastases from 2000 to 2020. Variables associated with the Liverpool score, C-reactive protein, albumins, and fibrinogen were ranked. The rankings were performed in four ways: The first two were based on the Kaplan-Meier method (log-rank statistics and the definite integral �� between two survival curves). The next method of ranking was based on univariate and multivariate Cox regression analyses. Results: The ranks were as follows: the radicality of liver resection (rank 1), lymph node infiltration of primary colorectal cancer (rank 2), elevated C-reactive protein (rank 3), the American Society of Anesthesiologists Classification grade (rank 4), the right-sidedness of primary colorectal cancer (rank 5), the multiplicity of colorectal liver metastases (rank 6), the size of colorectal liver metastases (rank 7), albumins (rank 8), and fibrinogen (rank 9). Conclusions: The ranking methodologies resulted in almost the same ranking order of the variables. Elevated C-reactive protein was ranked highly and can be considered a relevant replacement for the neutrophil–lymphocyte ratio in the Liverpool score. These methods are suitable for ranking variables in similar models for medical research.
Ključne besede: colorectal cancer, liver metastases, inflammation, ranking, survival
Objavljeno v DKUM: 07.04.2025; Ogledov: 0; Prenosov: 5
.pdf Celotno besedilo (1,15 MB)
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4.
The learning curve of laparoscopic liver resection utilising a difficulty score
Arpad Ivanecz, Irena Plahuta, Matej Mencinger, Iztok Peruš, Tomislav Magdalenić, Špela Turk, Stojan Potrč, 2022, izvirni znanstveni članek

Opis: Background: This study aimed to quantitatively evaluate the learning curve of laparoscopic liver resection (LLR) of a single surgeon. Patients and methods: A retrospective review of a prospectively maintained database of liver resections was conducted. 171 patients undergoing pure LLRs between April 2008 and April 2021 were analysed. The Halls difficulty score (HDS) for theoretical predictions of intraoperative complications (IOC) during LLR was applied. IOC was defined as blood loss over 775 mL, unintentional damage to the surrounding structures, and conversion to an open approach. Theoretical association between HDS and the predicted probability of IOC was utilised to objectify the shape of the learning curve. Results: The obtained learning curve has resulted from thirteen years of surgical effort of a single surgeon. It consists of an absolute and a relative part in the mathematical description of the additive function described by the logarithmic function (absolute complexity) and fifth-degree regression curve (relative complexity). The obtained learning curve determines the functional dependency of the learning outcome versus time and indicates several local extreme values (peaks and valleys) in the learning process until proficiency is achieved. Conclusions: This learning curve indicates an ongoing learning process for LLR. The proposed mathematical model can be applied for any surgical procedure with an existing difficulty score and a known theoretically predicted association between the difficulty score and given outcome (for example, IOC).
Ključne besede: difficulty score, learning curve, laparoscopy, hepatectomy, intraoperative complications, surgical procedures
Objavljeno v DKUM: 07.04.2025; Ogledov: 0; Prenosov: 2
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An eye-tracking study on the effect of different signalized intersection typologies on pedestrian performance
Chiara Gruden, Irena Ištoka Otković, Matjaž Šraml, 2022, izvirni znanstveni članek

Opis: Pedestrian safety is a well-known issue, such that many road safety associations emphasize measures to improve this aspect. One of the main conflict points is pedestrian crossings, where motorized and non-motorized traffic flows directly interact and where pedestrian attention and reaction are two elements that can strongly influence their safety. Nowadays, these aspects are often deviated by the use of smartphones to surf the Internet or social media. The aim of the present study is to find out (1) whether and how intersection typology affects pedestrian behavior, both in terms of attention and crossing performance, and (2) whether and how gaze and behavioral characteristics are affected by smartphone use and social media browsing. To achieve this goal, eye-tracking technology was used to obtain qualitative and quantitative information on the number of fixations, their duration, and reaction times of pedestrians. Additionally, from the eye-tracking videos, it was possible to derive pedestrian waiting times, crossing times, and speeds. Statistical tests were conducted to determine if there is a significant difference in pedestrian behavior at the three different types of intersections and in their behavior when using or not using their device. Results confirm the initial hypotheses and quantify the difference in pedestrian gaze behavior and crossing performance when walking across three different types of signalized crosswalks.
Ključne besede: pedestrian, eye-tracking, gaze behavior, reaction time, signalized intersection, crossing behavior
Objavljeno v DKUM: 13.03.2025; Ogledov: 0; Prenosov: 5
.pdf Celotno besedilo (2,86 MB)
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7.
Stabilization of verdigris pigment on paper : evaluation of antioxidants under mild accelerated degradation conditions
Jasna Malešič, Klara Retko, Matjaž Finšgar, Irena Kralj Cigić, 2025, izvirni znanstveni članek

Opis: Copper-based pigments, such as verdigris, have caused severe damage to many important historical documents, and their preservation remains a significant concern for paper conservators and researchers. This study re-evaluates the efficacy of two promising antioxidants, tetrabutylammonium bromide (TBABr) and benzotriazole (BTA), as stabilization agents for paper documents containing verdigris pigment. The evaluation was conducted under mild accelerated degradation conditions using historically accurate mock-up paper samples. To assess the stability of the mock-up papers, various parameters were measured during accelerated degradation, including colour, molecular weight (Mw), and pH value. Size exclusion chromatography measurements of Mw confirmed that TBABr provided superior stabilization compared to BTA. Additionally, the total colour change was slightly more pronounced in the samples treated with BTA compared to those treated with TBABr. However, during degradation, some paper samples containing thicker application of pigment exhibited significant black and brown spots, regardless of treatment (untreated, treated with BTA, or TBABr). X-ray photoelectron spectroscopy confirmed the presence of both Cu(I) and Cu(II) oxidation states in all samples, with a higher Cu(II) content on the surface of TBABr treated samples compared to those treated with BTA. This may indicate differences in the mechanisms of degradation. Raman spectroscopy identified the spots on both untreated and TBABr-treated samples as copper(II) oxide.
Ključne besede: verdigris, papir, razgradnja, stabilizacija, antioksidanti, ohranjanje dokumentov
Objavljeno v DKUM: 13.03.2025; Ogledov: 0; Prenosov: 1
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8.
Optimal L(d,1)-Labeling of Certain Direct Graph Bundles Cycles over Cycles and Cartesian Graph Bundles Cycles over Cycles
Irena Hrastnik Ladinek, 2024, izvirni znanstveni članek

Opis: An L(d,1)-labeling of a graph G=(V,E) is a function f from the vertex set V(G) to the set of nonnegative integers such that the labels on adjacent vertices differ by at least d and the labels on vertices at distance two differ by at least one, where d≥1. The span of f is the difference between the largest and the smallest numbers in f(V). The λ1d-number of G, denoted by λ1d(G), is the minimum span over all L(d,1)-labelings of G. We prove that λ1d(X)≤2d+2, with equality if 1≤d≤4, for direct graph bundle X=Cm×σℓCn and Cartesian graph bundle X=Cm□σℓCn, if certain conditions are imposed on the lengths of the cycles and on the cyclic ℓ-shift σℓ.
Ključne besede: L(d, 1)-labeling, λ d 1 -number, direct product of graph, direct graph bundle, Cartesian product of graph, Cartesian graph bundle, cyclic ℓ-shift, channel assignment
Objavljeno v DKUM: 13.03.2025; Ogledov: 0; Prenosov: 6
.pdf Celotno besedilo (338,54 KB)
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Changing epidemiology of presumptive community-associated-methicillin-resistant Staphylococcus aureus in Slovenia in 2014-2015 compared to 2010
Urška Dermota, Irena Grmek-Košnik, Sandra Janežič, Maja Rupnik, 2020, izvirni znanstveni članek

Opis: Introduction: Although the distinction between the Community-Associated-Methicillin-Resistant Staphylococcus aureus (CA-MRSA) and Hospital-Associated-Methicillin-Resistant S. aureus (HA-MRSA) has blurred in recent years, the CA-MRSA is an important group because of its potential to cause fulminant and severe infections. Its importance has further increased with the emergence of Livestock-Associated-Methicillin-Resistant S. aureus (LA-MRSA). Methods: In the present study we analysed clonal distributions and virulence factors in presumptive CA-MRSA isolated from January 2014 to December 2015 and compared the results with our previous study from 2010. Phenotypic definition for presumptive CA-MRSA was based on resistance to cefoxitin and oxacillin and susceptibility to at least two of the following four antibiotics: ciprofloxacin, erythromycin, clindamycin and gentamicin. Results:In 2014 and 2015 altogether 304 MRSA isolates fulfilled our screening phenotypic definition, 45 isolates were cultivated from clinical specimens and 259 from screening specimens. Sequence types ST398, LA-MRSA and mecC MRSA increased significantly in 2015 compared to 2010 (p-value <0.05) and were spread over Slovenia. Conclusion:The clonal distribution of presumptive CA-MRSA has changed within the study period in Slovenia. In 2015 the most frequent clone among clinical and screening specimens was a pig-associated clone, ST398, but the number of confirmed ST398 infections remains low. While previously ST398 and mecC positive MRSA strains were geographically limited, they have spread throughout the country since 2010.
Ključne besede: Slovenia, CA-MRSA, LA-MRSA, mecC, spa types, clones
Objavljeno v DKUM: 20.01.2025; Ogledov: 0; Prenosov: 403
.pdf Celotno besedilo (1,32 MB)
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