1. Which positive view of general practice do medical students and trainees have? : a systematic literature reviewBernard Le Floch, Hilde Bastiaens, Jean-Yves Le Reste, Heidrun Lingner, Robert Hoffman, Radost Spiridonova Assenova, Tuomas Koskela, Zalika Klemenc-Ketiš, P. Nabbe, T Montier, Lieve Peremans, 2020, pregledni znanstveni članek Opis: Background: Despite several studies focusing on the negative aspects of general medicine, the speciality seems attractive for students. Researchers from the European General Practice Research Network created a group to study job satisfaction in general practice. The aim of this eight-country European study was to determine which positive view students have about general practice.
Method: Systematic review of the literature from Pubmed, Embase and Cochrane databases. Articles published between 01/01/2000 and 12/31/2018 were searched and analysed by two researchers working blind. The data on satisfaction factors were extracted from the full text article used as verbatims. Then the data were coded with a thematic analysis.
Results: 24 articles out of 414 were selected. Satisfaction factors were classified: teaching of general practice, workplace and organisational freedom, quality of life, variety in practice, workload balance and income. The analysis highlighted intellectual stimulation and the relationship built with patients and other professionals.
Conclusion: Literature on the appeal of general practice for students revealed many factors of job satisfaction in general practice. It is possible to create a global view of a satisfied GP on the students' opinion. Courses and clerkships in general practice with positive rolemodels are determining factors in career choice.
Ključne besede: medical students, career choice, general practitioners, job satisfaction, primary healthcare
Objavljeno v DKUM: 20.11.2025; Ogledov: 0; Prenosov: 1
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2. Protokol za klinično kirurško tutorstvo : gradivo za študente medicine in študente tutorje2025 Opis: Protokol za kirurško tutorstvo je izdelek, ki je od ideje do izdaje nastajal tekom študijskih let zdajšnjih diplomantov Medicinske fakultete Univerze v Mariboru, mladih.zdravnikov. Gradivo zajema teme od pojasnilne dolžnosti do alternativkirurškega šivanja, vključujoč osnove obnašanja v operacijski dvorani, predstavitev kirurških instrumentov, antiseptične priprave sterilnega polja, sivi in vozlanje. Koraki posameznih protokolov so zapisani po točkah, tekst pa spremljajo ilustracije kolegice, ravno tako diplomantke MF UM, mlade zdravnice. Gradivo je plod truda in usklajevanja kolegov in mentorjev; vsi, ki smo pri skripti sodelovali upamo, da bo sluzila svojemu namenu.
Ključne besede: kirurgija, šivanje, protokoli, instrumenti, veščine, tutorstvo
Objavljeno v DKUM: 24.10.2025; Ogledov: 0; Prenosov: 4
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3. Exploring genital lichen sclerosus : navigating from pathophysiology to precise diagnostic approachesMaja Sever, Katarina Trčko, Tanja Zidarič, Tina Maver, 2025, pregledni znanstveni članek Opis: Lichen sclerosus (LS) is a chronic, relapsing skin disease that predominantly affects the perineal and genital regions, although extragenital manifestations can occur. Despite its significant impact on patients’ quality of life, particularly affecting sexual and urinary function, LS remains underdiagnosed. Multiple factors, including genetic predisposition, hormonal changes, immunological abnormalities, trauma, and urine irritation, contribute to its development and persistence. This review aims to clarify the complex pathophysiology of LS by exploring three main mechanisms: autoimmune dysregulation, sclerotic tissue formation, and oxidative stress. Autoimmune dysregulation involves T-cell infiltration and the roles of miR-155 and extracellular matrix protein 1 dysfunction, leading to chronic inflammation. miR-155 contributes to sclerotic tissue formation alongside galectin-7, promoting fibroblast proliferation and collagen synthesis. Oxidative stress results in tissue damage, autoimmunity, chronic inflammation, and an increased risk of carcinogenesis. Understanding these mechanisms is crucial for developing targeted therapies and improving LS management. Further research is needed to unravel the genetic basis, immune responses, and interactions between key mediators, ultimately advancing innovative therapeutic strategies and precision medicine in LS.
Ključne besede: lichen sclerosus, autoimmune dysregulation, sclerotic tissue, oxidative stress, genital disease
Objavljeno v DKUM: 15.09.2025; Ogledov: 0; Prenosov: 45
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4. Effect of phenolic anchor groups on enzymatic polymerization of coniferyl alcohol at cellulosic interfacesThomas Elschner, Jakob Schönrich, Matej Bračič, Tina Maver, Uroš Maver, Steffen Fischer, 2025, izvirni znanstveni članek Opis: The chemical recalcitrance of lignin limits the industrial processing of biomass, which could be addressed by so-called designer lignins. Dehydrogenation polymers (DHPs) formed by artificial lignification of monolignols, enable studies on structure-property relationships independently of genetic information. Thin films of phenolic acid esters of cellulose were prepared and used for quartz crystal microbalance with dissipation monitoring (QCM-D) experiments to investigate surface polymerization in real-time. The phenolic anchor groups significantly influenced lignification speed, deposited mass, and rigidity of resulting DHP layers. Linkage types in the lignin structure were quantified by HSQC NMR spectroscopy. Polymerization efficiency was increased in the order ferulate < p-coumarate < caffeate. Among the tested anchors, protocatechuate groups were excellently performing the reaction, while vanillate and p-hydroxybenzoate led to minimal deposition of DHPs. Lignification behavior could be correlated with radical stability of phenolic anchor groups and the formation of benzodioxane structures of caffeate moieties. The presence of caffeate units that undergo trapping reaction, prevents cross-linking of cell wall components and enhances digestibility. Moreover, the benzodioxane motif increased rigidity and linearity of lignin, which is advantageous for material science applications, e.g. for bio-based carbon fibers.
Ključne besede: artificial lignin, dehydrogenation polymerization, phenolic cellulose esters, QCM-D, thin films
Objavljeno v DKUM: 15.09.2025; Ogledov: 0; Prenosov: 2
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5. Urinary catheters : state of the art and future perspectives – a narrative reviewKristijan Skok, Uroš Bele, Špela Pintar, Zdenka Peršin Fratnik, Katja Kuzmič, Matej Bračič, Lidija Fras Zemljič, Uroš Maver, 2025, pregledni znanstveni članek Opis: Catheter associated urinary tract infection (CAUTI) is the most frequent healthcare associated infection, arising from microbial adhesion to catheter surfaces, biofilm development, and the growing problem of antimicrobial resistance. Many publications have addressed CAUTI epidemiology, biofilm biology, or biomaterials for catheters in isolation, yet there is little literature that connects these areas into a coherent translational perspective. This review seeks to fill that gap by combining an overview of biofilm pathophysiology with recent advances in material based innovations for catheter design, including nanostructured and responsive coatings, sensor enabled systems, additive manufacturing, and three dimensional printing. Established approaches such as hydrophilic or antimicrobial impregnated catheters are considered alongside bio inspired surface textures, zwitterionic polymers, and multifunctional hydrogels. Each strategy is evaluated in terms of maturity, clinical applicability, and barriers to translation, with a focus on shifting from antibiotic dependent treatment toward prevention of biofilm formation. By bringing together knowledge from microbiology, engineering, and clinical urology, the review outlines pathways for developing the next generation of catheters that improve outcomes and reduce infection rates.
Ključne besede: urinary catheters, urinary tract infection, antibiotic resistance, nanotechnology, biomedical engineering
Objavljeno v DKUM: 15.09.2025; Ogledov: 0; Prenosov: 1
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6. Case report: Clinical pharmacist prescriber in depression treatment in primary care settings: clinical case focused on prescribing practiceMatej Štuhec, 2025, drugi znanstveni članki Opis: Introduction: Pharmacotherapy of depression represents a significant challenge in the management of depression in primary care. Although effective treatments have been available, many patients are still not adequately managed. Clinical pharmacists represent one of the possible strategies in the management, although this practice is rarely seen outside the United Kingdom and the United States. Aim: The aim of the case was to evaluate the impact of clinical pharmacist prescribers on depression treatment. Methods: A longitudinal, observational, case-based medication review by a pharmacist prescriber was conducted for a 63-year-old Slovenian patient in a primary care ambulatory setting. The review included three structured medication review assessments performed by a clinical pharmacist prescriber at defined intervals: first observation, two months post-intervention, and six months after first observation. The pharmacists conducted medication reviews and prescribed medications like physicians, operating within a collaborative practice agreement as dependent prescribers. Predefined outcomes included diabetes management (HbA1c and blood glucose), lipid levels (S-LDL), pain (Visual Analogue Scale [VAS]), depression (Patient Health Questionnaire-9 [PHQ-9]), and quality of life (assessed via EQ-5D-VAS). The patient’s complete medication regimens were reviewed, focusing on dosage appropriateness, indication matching, potential drug-drug interactions, and medication adherence. Results: A 63-year-old male Slovenian patient diagnosed with depression, type 2 diabetes with polyneuropathy, and hypothyroidism underwent two medication reviews between December 2024 and July 2025. The pharmacist prescribed amitriptyline and semaglutide (accepted by the patient’s physician). Notable improvements were observed in glycemic control (HbA1c reduced from 9.9% to 8.2%), and quality of life (EQ-5D-VAS score improved from 30/100 to 80/100). Depression symptoms also resolved, with the PHQ-9 score improving from 11 to 4. Conclusions: This case study demonstrates that interventions by a clinical pharmacist prescriber during the medication review process resulted in improved clinical outcomes in the treatment of depression, as well as enhanced quality of life. It represents an important contribution to the development of pharmacist prescribing roles in depression management within primary care settings outside of the United Kingdom and the United States.
Ključne besede: depression, pharmacist prescriber, clinical pharmacy, ambulatory care, medication review
Objavljeno v DKUM: 15.09.2025; Ogledov: 0; Prenosov: 7
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7. Functionalized micellar membranes from medicinal mushrooms as promising self-growing bioscaffoldsNika Kučuk, Mateja Primožič, Željko Knez, Maja Leitgeb, 2025, izvirni znanstveni članek Opis: Micellar or mycelial membranes from medicinal mushrooms are self-growing fibrous polymeric biocomposites that are biocompatible, biodegradable, cost-effective, and environmentally friendly. In this study, the cultivation process for the medicinal mushrooms Ganoderma lucidum and Pleurotus ostreatus has been optimized via submerged cultivation to maximize growth and promote the formation of micellar membranes with high water-absorption capacity. Optimal growth conditions were achieved at an alkaline pH in a medium containing malt extract for G. lucidum, while for P. ostreatus, these were in a glucose-enriched medium. The hydrophilic underside of the micellar membranes led to a high-water uptake capacity. These membranes exhibited a broad spectrum of functional groups, thermal stability with decomposition temperatures above 260 °C, and a fibrous and porous structure. The micellar membranes from both mushrooms were additionally functionalized with mango peel extract (MPE), resulting in a uniform and gradual release profile, which is an important novelty. They also showed successful antimicrobial activity against Escherichia coli and Staphylococcus aureus growth. MPE-functionalized micellar membranes are, therefore, innovative biocomposites suitable for various biomedical applications. As they mimic the extracellular matrix of the skin, they are a promising material for tissue engineering, wound healing, and advanced skin materials applications.
Ključne besede: medicinal mushrooms, Ganoderma lucidum, Pleurotus ostreatus
Objavljeno v DKUM: 04.09.2025; Ogledov: 0; Prenosov: 4
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9. Comparative efficacy and safety of alternatives to sodium valproate in the management of bipolar affective disorder in people of child-bearing age : a narrative review by the European Society of Clinical Pharmacy's mental health specialist interest groupIta Fitzgerald, Izgi Bayraktar, Birgit Eiden, Rosalind Gittins, Erica Magni, Marie Humbert-Claude, Lara-Turiya Molitschnig, Paula Darm, Anna Waksmundzka-Walczuk, Nikolaus Riesenhuber, Matej Štuhec, Ivana Tašková, Martina Hahn, 2025, pregledni znanstveni članek Ključne besede: bipolar affective disorder, bipolar disorder, mood stabilisers, narrative review, pregnancy, sodium valproate, teratogenicity
Objavljeno v DKUM: 22.08.2025; Ogledov: 0; Prenosov: 4
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10. Assessing acute pancreatitis : a novel method combining live cell imaging with tissue damage evaluationPolona Kovačič, Maša Skelin, Eva Paradiž, Viktória Venglovecz, Loránd Kiss, Gabriella Mihalekné Fűr, Andraž Stožer, Jurij Dolenšek, 2025, izvirni znanstveni članek Opis: Acute pancreatitis (AP) is a sudden inflammation of the exocrine part of the pancreas, resulting in self-digestion and destruction of exocrine tissue. The intricate relationship between exocrine and endocrine functions is pivotal, as damage to acinar cells can affect endocrine cell function and vice versa. However, our understanding of these interactions remains limited. An effective strategy for investigating pancreatic cells involves the utilization of live in-situ acute mouse pancreas tissue slice preparations, combined with noninvasive fluorescent calcium labeling of endocrine or exocrine cells, and subsequent analysis using confocal laser scanning microscopy. Nevertheless, this approach encounters inherent conflicts with conventional methodologies employed to histologically assess the severity of tissue damage due to AP in the model. Traditional methods involve fixing and staining tissue samples with hematoxylin and eosin, thereby precluding live-cell imaging. In this study, our objective was to introduce an innovative method utilizing a commercial fluorescence Live/Dead assay that enables calcium imaging and tissue damage assessment in the same sample. This approach was validated against the classical histological grading of AP severity, and we found a good correlation between the classical histological grading method and the in-situ approach employing the Live/Dead assay. The primary advantage of our novel approach lies in its capacity to enable timely and efficient live-cell imaging together with damage assessment in the same tissue, thereby enabling the study of functional consequences of structural damage at the cellular level and reducing the number of animals required for experimentation.
Ključne besede: acute pancreatitis, pancreatic tissue damage, exocrine and endocrine interactions, live cell imaging, confocal laser scanning microscopy, calcium imaging, live/dead assay, tissue slice preparation, histological grading
Objavljeno v DKUM: 22.08.2025; Ogledov: 0; Prenosov: 5
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