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9. Vrednotenje učinkovitosti modelne medicinske obloge z vgrajenimi magnetnimi nanodelci in protitumorsko učinkovino na humanih celicah kožnega rakaKristjan Orthaber, Matevž Pristovnik, Kristijan Skok, 2017, final research report Keywords: kožni rak, motivacija, medicinske obloge, 5-fluorouracil, biokompatibilni polimeri, nadzorovano sproščanje, in vitro celični testi
Published: 23.07.2018; Views: 21; Downloads: 7
 Full text (2,22 MB) |
10. Genetic etiology of primary premature ovarian insuffiencyMaja Franic Ivanisevic, Damir Franić, Miomira Ivovic, Milina Tancic Gajic, Ljiljana Marina, Marija Barac, Svetlana Vujovic, 2016, review article Abstract: Primary premature ovarian insufficiency (PPOI) is characterized by hypergonadotropic amenorrhea and hypoestrogenism in women under 40 years of age. PPOI incidence is 1:10,000 in women aged 18-25, 1:1000 in women aged 25-30 and 1:100 in women aged 35-40. In 10%-28% of cases, PPOI causes primary and in 4%-18% secondary amenorrhea. The process is a consequence of accelerated oocyte atresia, diminished number of germinated cells, and central nervous system aging. Specific genes are responsible for the control of oocyte number undergoing the ovulation process and the time to cessation of the reproductive function. A positive family history of PPOI is found in 15% of women with PPOI, indicating the existing genetic etiology. Primary POI comprises genetic aberrations linked to chromosome X (monosomy, trisomy, translocation, deletion) or to autosomal chromosome. Secondary POI implies surgical removal of ovaries, chemotherapy and radiotherapy, and infections. Diagnostic criteria include follicle stimulating hormone level >40 IU/L and estradiol level <50 pmol/L.
Keywords: primary ovarian insufficiency, etiology, genetics
Published: 08.05.2018; Views: 64; Downloads: 5
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