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41.
Nevarnosti in ugotavljanje hipervitaminoz askorbinske kisline in vitamina D
Boštjan Muminović, 2016, druge monografije in druga zaključena dela

Ključne besede: vitamin C, vitamin D, hipervitaminoza, prehranski dodatek, toksični učinki
Objavljeno: 02.08.2017; Ogledov: 70; Prenosov: 12
.pdf Celotno besedilo (486,06 KB)

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Ruralne ambulante družinske medicine
Rok Petrovčič, 2016, druge monografije in druga zaključena dela

Ključne besede: podeželje, motivacija, štipendija, družinska medicina, podeželska medicina
Objavljeno: 02.08.2017; Ogledov: 48; Prenosov: 5
.pdf Celotno besedilo (1,40 MB)

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Ugotavljanje zgodnjih napovednikov srčno- žilne ogroženosti pri otrocih z esencialno hipertenzijo
Andreja Štelcar, 2017, doktorsko delo/naloga

Opis: Izhodišča: Arterijska hipertenzija (AH) je ob aterosklerozi najpogostejša bolezen obtočil pri odraslih in predstavlja enega glavnih dejavnikov tveganja za nastanek in razvoj srčno-žilnih bolezni. Z vse večjo pojavnostjo debelosti v populaciji otrok in mladostnikov je postala esencialna arterijska hipertenzija (EH) ena najpogostejših kroničnih bolezni tudi v otroški dobi. AH je povezana z nastankom poškodb hipertenzivnih tarčnih organov in s tem z nastankom srčno-žilnih bolezni. Čeprav se pri otrocih srčno-žilne bolezni v manifestni obliki redko pojavljajo, rezultati številnih raziskav kažejo, da se proces ateroskleroze začne že v otroštvu. To velja tudi za pojavljanje srčno-žilnih dejavnikov tveganja, med katerimi je tudi AH, ki proces ateroskleroze pospešujejo. Da bi preprečili ali vsaj omilili nastanek srčno-žilnih bolezni, je pomembno pravočasno odkritje in zdravljenje bolezni oziroma zgodnjih sprememb. To še prav posebej velja za otroško populacijo, pri kateri so zato raziskave usmerjene v iskanje čim zgodnejših pokazateljev hipertenzivne poškodbe in prisotnosti drugih domnevnih srčno-žilnih dejavnikov tveganja. Metode: V raziskavo smo vključili 100 otrok obeh spolov, ki so se zdravili na Kliniki za pediatrijo UKC Maribor, in smo jim trikrat zapored v različnih razmerah izmerili povišan krvni tlak (KT) ter ga nato potrdili s 24-urnim merjenjem KT ter postavili diagnozo EH. Kontrolno skupino otrok je sestavljalo 50 po spolu in starosti primerljivih zdravih otrok z normalnim KT. Opravili smo natančno anamnezo in klinični pregled, pri preiskovani skupini pa še pregled očesnega ozadja. Pri vsakem posamezniku smo izmerili telesno težo, telesno višino ter obseg pasu in bokov. Iz omenjenih meritev smo izračunali indeks telesne mase (BMI). Po standardnem postopku smo v krvi določili hemogram, reaktivni protein C (CRP), sečnino, kreatinin, sečno kislino, elektrolite, koncentracijo celokupnega holesterola, holesterola HDL, holesterola LDL, trigliceridov, krvnega sladkorja, homocisteina, apolipoproteina A1(apoA1) in B (apo B), lipoproteina (a), insulina in mikroalbumina v urinu. Adiponektin in leptin smo določali s kvantitativno sendvič imunoencimsko metodo, grelin pa po postopku kvantitativne sendvič ELISE. Za določitev fibrinogena smo uporabili modificirano metodo po Claussu. Inhibitor aktivatorja plazminogena (PAI-1) smo določili kromatografsko. Vsem otrokom smo opravili ultrazvočno meritev debline intime-medije (IMT) vratnih žil, ultrazvočno meritev mase levega prekata (LVM) in z aplanacijsko tonometrijo opravili meritev žilne kompliance (PWV). Rezultati: Med otroci z EH in kontrolno skupino smo ugotovili statistično značilne razlike v telesni teži (p < 0,001), obsegu pasu (p < 0,001), razmerju pas/boki (p < 0,001) in BMI (p < 0,001). Otroci z EH so imeli izrazito višje vrednosti holesterola LDL (p = 0,032), trigliceridov (p = 0,011), insulina (p < 0,001), sečne kisline (p = 0,002), krvnega sladkorja (p = 0,003) in nižje vrednosti holesterola HDL (p = 0,017) in apolipoproteina A1 (p = 0,008). Statistično pomembno razliko v adipokinih smo uspeli dokazati le za adiponektin (p < 0,010). Otroci z EH so imeli tudi višje vrednosti vseh morfoloških preiskav, a statistično pomembne razlike smo potrdili le za LVM (p < 0,001), debelino zadnje stene levega prekata (p < 0,001), debelino medprekatnega pretina (p < 0,003), IMT desno (p < 0,001), IMT levo (p < 0,001), medtem ko se skupini v vrednostih PWV nista statistično razlikovali. Kljub vsemu je imela skupina z EH statistično višje vrednosti nekaterih drugih posrednih znakov zmanjšane žilne kompliance, kot sta pulzni tlak v aorti (AoPP) (p < 0,001) in augmentacijski indeks korigiran za srčno frekvenco 75/min (Alx@HR 75) (p = 0,044).
Ključne besede: Esencialna hipertenzija, otrok, zgodnji napovedniki srčno - žilne ogroženosti, laboratorijski kazalci, morfološki kazalci
Objavljeno: 31.07.2017; Ogledov: 191; Prenosov: 18
.pdf Celotno besedilo (3,75 MB)

48.
The role of the European Academy of Teachers in General Practice and Family Medicine in family medicine education in Europe
Zalika Klemenc-Ketiš, Janko Kersnik, 2012, pregledni znanstveni članek

Opis: Primary health care is important item of political agendas since Alma Ata conference in 1978. West Balkans share common history in development of primary care since 1920' when Andrija Stampar introduced social and community based primary care concepts. The first known specialist training in general practice in the world started in former Yugoslavia in the early 1960'. Since then, much has been done in the field of general practice and family medicine and this is reflected in The European Academy of Teachers in General Practice and Family Medicine (EURACT), which is a network organisation within World Organization of National Colleges, Academies and Academic Associations of General Practitioners/Family Physicians Region Europe (WONCA Europe). Its aim is to foster and maintain high standards of care in European general practice by promoting general practice as a discipline by learning and teaching. EURACT developed several documents and teachers' courses which can serve the development of family medicine curricula in new established departments of medical schools. This is also the case at Maribor Medical School, where learning outcomes and teaching methods are in concordance with EURACT teaching agenda, but also some innovative approaches are used, such as art and e-learning environment as teaching methods.
Ključne besede: family practice, education, Europe, Slovenia
Objavljeno: 24.07.2017; Ogledov: 88; Prenosov: 4
.pdf Celotno besedilo (83,80 KB)

49.
Importance of international networking in academic family medicine
Zalika Klemenc-Ketiš, Janko Kersnik, 2014, pregledni znanstveni članek

Opis: European family medicine/general practice (FM/GP) has travelled the long and successful journey of profiling the discipline and has produced valuable position papers on education and research. Nowadays, academic medicine is one of the pillars in the future development of FM/GP in Europe. A common European curriculum on undergraduate and postgraduate family medicine is needed. Also, a sound international platform of teaching institutions and/or teachers of family medicine would foster the further development of family medicine as an academic discipline. This would stimulate students and teachers to engage in international exchange to gain new knowledge and experiences, present their work and ideas abroad and prepare the conditions for further exchange of students and teachers. Conclusion: Established departments of FM/GP, led by a teacher who is a family physician/general practitioner, at each Medical School in Europe should provide students with knowledge and skills related to the core attributes of FM/GP. International exchanges of teachers and students should foster the development of a common curriculum on FM in Europe and foster improvement in the quality of FM education.
Ključne besede: family practice, education, network, exchange
Objavljeno: 24.07.2017; Ogledov: 97; Prenosov: 2
.pdf Celotno besedilo (71,97 KB)

50.
Specific behavioural phenotype and secondary cognitive decline as a result of an 8.6 Mb deletion of 2q32.2q33.1
Hojka Gregorič Kumperščak, Danijela Krgović, Nadja Kokalj-Vokač, 2016, izvirni znanstveni članek

Opis: Chromosomal abnormalities involving 2q32q33 deletions are very rare and present with a specific phenotype. This case report describes a 37-year-old female patient with 2q32q33 microdeletion syndrome presenting with the characteristic features, but with the addition of secondary cognitive decline. Molecular karyotyping was performed on the patient and her parents. It revealed an 8.6 megabase deletion with the proximal breakpoint in the chromosome band 2q32.2 and the distal breakpoint in 2q33.1. The deletion encompassed 22 known genes, including the GLS, MYO1B, TMEFF2, PGAP1 and SATB2 genes. The observed deletion was confirmed using a paralogue ratio test. This case report provides further evidence that the SATB2 gene, together with GLS, MYO1B, TMEFF2 and possibly PGAP1, is a crucial gene in 2q32q33 microdeletion syndrome. The SATB2 gene seems to be crucial for the behavioural problems noted in our case, but deletion of the GLS, MYO1B and TMEFF2 genes presumably contributed to the more complex behavioural characteristics observed. Our patient is also, to our knowledge, the only patient with 2q32q33 microdeletion syndrome with secondary cognitive decline.
Ključne besede: 2q32q33 microdeletion syndrome, behavioural problems, secondary cognitive decline, developmental delay, SATB2 gene
Objavljeno: 13.07.2017; Ogledov: 74; Prenosov: 3
.pdf Celotno besedilo (411,05 KB)

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