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Multilayer methacrylate-based wound dressing as a therapeutic tool for targeted pain relief
Tanja Zidarič, Kristijan Skok, Kristjan Orthaber, Matevž Pristovnik, Lidija Gradišnik, Tina Maver, Uroš Maver, 2023, izvirni znanstveni članek

Opis: This study presents an innovative wound dressing system that offers a highly effective therapeutic solution for treating painful wounds. By incorporating the widely used non-steroidal anti-inflammatory drug diclofenac, we have created an active wound dressing that can provide targeted pain relief with ease. The drug was embedded within a biocompatible matrix composed of polyhydroxyethyl methacrylate and polyhydroxypropyl methacrylate. The multilayer structure of the dressing, which allows for sustained drug release and an exact application, was achieved through the layer-by-layer coating technique and the inclusion of superparamagnetic iron platinum nanoparticles. The multilayered dressings’ physicochemical, structural, and morphological properties were characterised using various methods. The synergistic effect of the incorporated drug molecules and superparamagnetic nanoparticles on the surface roughness and release kinetics resulted in controlled drug release. In addition, the proposed multilayer wound dressings were found to be biocompatible with human skin fibroblasts. Our findings suggest that the developed wound dressing system can contribute to tailored therapeutic strategies for local pain relief.
Ključne besede: wound dressings, pain relief, superparamagnetic nanoparticles, methacrylate
Objavljeno v DKUM: 19.04.2024; Ogledov: 33; Prenosov: 0
.pdf Celotno besedilo (1,61 MB)
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Association of circulating tumor cells, megakaryocytes and a high immune-inflammatory environment in metastatic breast cancer
Cvetka Grašič-Kuhar, Silvester Jernej, Marina Mencinger, Tanja Ovčariček, Maja Čemažar, Simona Miceska, Živa Modic, Anamarija Kuhar, Tanja Jesenko, Veronika Kloboves-Prevodnik, 2023, izvirni znanstveni članek

Opis: Liquid biopsy is becoming an important source of new biomarkers during the treatment of metastatic cancer patients. Using size-based microfluid technology, we isolated circulating tumor cells (CTCs) from metastatic breast cancer patients to evaluate their presence and cluster formation, as well as the presence of megakaryocytes and immune-inflammatory blood cells, and to correlate their presence with clinicopathological data and overall survival (OS). In total, 59 patients (median age 60.4 years) were included in the study: 62.7% luminal A/B-like, 20.3% HER2-positive, and 17% triple-negative. Our results showed that at least one CTC was present in 79.7% and ≥5 CTCs in 35.2% of the patients. CTC clusters were present in patients with ≥5 CTCs only (in 19.2% of them), and megakaryocytes were present in 52% of all patients. The presence of CTC clusters and megakaryocytes was positively associated with the CTC count. Patients with low pan-inflammatory value (PIV), low systemic immune-inflammatory index (SII), and low relative change from baseline (ΔPIV%, ΔSII%) were associated with significantly higher OS than their counterparts. ΔPIV%, the presence of infection in the last month, and a long duration of metastatic disease were identified as independent prognostic factors for OS. The interplay of CTCs, CTC clusters, megakaryocytes, and PIV needs to be further explored.
Ključne besede: breast cancer, circulating tumor cell, cluster, megakaryocyte, pan-inflammatory value, overall survival
Objavljeno v DKUM: 19.04.2024; Ogledov: 33; Prenosov: 3
.pdf Celotno besedilo (2,64 MB)
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Perceptions of the primary health care team about the implementation of integrated care of patients with type 2 diabetes and hypertension in Slovenia : qualitative study
Nataša Stojnić, Zalika Klemenc-Ketiš, Majda Mori-Lukančič, Črt Zavrnik, Tonka Poplas-Susič, 2023, izvirni znanstveni članek

Opis: Background Integrated care involves good coordination, networking, and communication within health care services and externally between providers and patients or informal caregivers. It affects the quality of services, is more cost-effective, and contributes to greater satisfaction among individuals and providers of integrated care. In our study, we examined the implementation and understanding of integrated care from the perspective of providers - the health care team - and gained insights into the current situation. Methods Eight focus groups were conducted with health care teams, involving a total of 48 health care professionals, including family physicians, registered nurses, practice nurses, community nurses, and registered nurses working in a health education center. Prior to conducting the focus groups, a thematic guide was developed based on the literature and contextual knowledge with the main themes of the integrated care package. The analysis was conducted using the NVivo program. Results We identified 12 main themes with 49 subthemes. Health care professionals highlighted good accessibility and the method of diagnostic screening integrated with preventive examinations as positive aspects of the current system of integrated care in Slovenia. They mentioned the good cooperation within the team, with the involvement of registered nurses and community nurses being a particular advantage. Complaints were made about the high workload and the lack of workforce. They feel that patients do not take the disease seriously enough and that patients as teachers could be useful. Conclusion Primary care teams described the importance of implementing integrated care for diabetes and hypertension patients at four levels: Patient, community, care providers, and state. Primary care teams also recognized the importance of including more professionals from different health care settings on their team.
Ključne besede: integrated health care system, type-2-diabetes, Hypertension, Health care team, interdisciplinary primary care, qualitative research
Objavljeno v DKUM: 19.04.2024; Ogledov: 30; Prenosov: 0
.pdf Celotno besedilo (1007,00 KB)
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Ali so pogosti obiskovalci za zdravnika tudi težavni bolniki?
Janko Kersnik, Marija Kuralt, 2008, izvirni znanstveni članek

Ključne besede: osnovno zdravstvo, družinska medicina, odnos zdravnik-bolnik, obiski, stres, konzultacija, težaven bolnik, pogosti obiskovalci
Objavljeno v DKUM: 19.04.2024; Ogledov: 16; Prenosov: 0
.pdf Celotno besedilo (123,10 KB)
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Pomen nujne endoskopije zgornjih prebavil pri odstranjevanju tujkov - rezultati obdobja 1994-2008
Pavel Skok, Andreja Ocepek, 2008, izvirni znanstveni članek

Opis: Purpose: Foreign bodies in the upper gastrointestinal tract (GIT) rarely cause urgent problems in gastroenterology. The purpose of the study was to assess the percentage of patients in whom urgent endoscopic investigation revealed true foreign bodies in the upper GIT and to evaluate the success of emergency endoscopic procedures. Methods: The study includes patients in whom urgent endoscopic investigations of the upper GIT were performed in the period 1 January 1994 to 1 May 2008. Results: 8552 patients were investigated,average age 60,6 years (SD +/- 17,1 years, range 1 - 106 years), with 3276 (38 %) females and 5276 males (62 %). In 69 patients (0,8 %), "true" foreign bodies were detected in the esophagus or stomach. In these patients a total of 90 endoscopic investigations were performed: in 65/69 patients (94,2 %) the foreign bodies were removed endoscopically; in 4 (5,8 %) cases the endoscopic procedures were unsuccessful. Among the foreign bodiesremoved were a variety metal or plastic objects, such as coins, keys, screws, hooks, batteries, razor blades, needles, lighters, buttons and parts of kitchen, toilet or writting utensils. In patients with successful endoscopic removal of the objects, no significant complications were noted. In 4 patients (4/69, 5,8 %) mild hemorrhages from the region of the esophagogastric junction were observed. Conclusion: Endoscopic technologies allow successful removal of a variety of types of foreign bodies from the upper GIT.
Ključne besede: tujki, zgornja prebavna cev, endoskopija, odstranitev, zapleti
Objavljeno v DKUM: 19.04.2024; Ogledov: 13; Prenosov: 0
.pdf Celotno besedilo (144,82 KB)
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Zdravje je blagostanje - vodilna vloga Evrope pri skrbi za zdravje
Felix Unger, 2008, pregledni znanstveni članek

Ključne besede: zdravje, blagostanje, tržišče, trg zdravja, vodilna vloga
Objavljeno v DKUM: 19.04.2024; Ogledov: 13; Prenosov: 0
.pdf Celotno besedilo (114,71 KB)
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Ob izidu 1. številke revije Acta medico-biotechnica
Dušica Pahor, 2008, predgovor, uvodnik, spremna beseda

Ključne besede: medicina, biotehnika, znanstvene revije
Objavljeno v DKUM: 19.04.2024; Ogledov: 13; Prenosov: 0
.pdf Celotno besedilo (1,04 MB)
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Nagovor dekana Medicinske fakultete Univerze v Mariboru
Ivan Krajnc, 2008, predgovor, uvodnik, spremna beseda

Ključne besede: Medicinska fakulteta Maribor, medicina, biotehnika, znanstvene revije
Objavljeno v DKUM: 19.04.2024; Ogledov: 17; Prenosov: 0
.pdf Celotno besedilo (933,22 KB)
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