1. Synergistic effect of supercritical and ultrasound-assisted ginger (Zingiber officinale Roscoe) extractsTaja Žitek Makoter, Nika Kučuk, Vesna Postružnik, Maja Leitgeb, Željko Knez, Mateja Primožič, Maša Knez Marevci, 2022, izvirni znanstveni članek Opis: Proper processing of natural material is crucial to obtain an extract with high content of
biologically active components. Dried, grinded ginger roots were extracted by ultrasonic method
and supercritical extraction with CO2
. The aim of the study was to determine if a mixture of the two
types of extracts attained by different methods and solvents exhibits better bioavailability than each
extract itself. Therefore, both extracts were analytically evaluated and then mixed in a ratio of 1:1.
The supercritical extract (SCG extract) and the mixed extract (mixG extract) had high antioxidant
activity (78% and 73%) and total phenols (827 mg/g ext. and 1455 mg/g ext.), which is also consistent
with the levels of gingerol (303 mg/g ext. and 271 g/g ext.) and shogaol (111 mg/g ext. and 100 g/g
ext.) in the extracts. In comparison to both pure extracts higher levels of total phenols were found
in the extract mixG. This could be the reason for the significant inhibition of melanoma cells and
antimicrobial potential (against Staphylococcus aureus, Escherichia coli, and Candida albicans). The
combination of the extracts resulted in a significant increase in the inhibition of selected microbial
and melanoma cells WM-266-4 compared to the control. Cell viability decreased below 60% when
mixG extract was applied. Antimicrobial activity has been confirmed.
Ključne besede: ginger, supercritical fluid extraction, ultrasound-assisted extraction, antimicrobial activity
Objavljeno v DKUM: 09.05.2025; Ogledov: 0; Prenosov: 1
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2. Optimisation of the green process of industrial hemp - preparation and its extract characterisationTaja Žitek Makoter, Petra Kotnik, Teo Makoter, Vesna Postružnik, Željko Knez, Maša Knez Marevci, 2022, izvirni znanstveni članek Opis: Natural medicines and products are becoming increasingly important in the pharmaceutical
and food industries. The most important step in obtaining a natural remedy is the processing of
the natural material. This study offers the separation of the industrial hemp plant into fractions by
mechanical treatment, which has a significant impact on the selectivity of the obtained fractions. This
study also offers a solution to reduce waste by fractionating industrial hemp, focusing on the fraction
with the highest cannabinoid content (49.5% of CBD). The study confirmed the anticancer potential
of the extract, which prevents further division of WM-266-4 melanoma cells at a concentration of
10−3 mg/mL. However, application of the extract (c = 10−3 mg/mL) to normal human epidermal
melanocytes proved to be insignificant, as the metabolic activity of the cells was the same as in the
control cell group.
Ključne besede: supercritical fluid extraction, ultrasonic extraction, melanoma cells, extraction, WM-266-4
Objavljeno v DKUM: 09.05.2025; Ogledov: 0; Prenosov: 2
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4. Design and optimization of a spherical magnetorheological actuatorJakob Vizjak, Anton Hamler, Marko Jesenik, 2023, izvirni znanstveni članek Opis: Recently, an increasing number of electromagnetic devices have been using smart fluids. These include ferrofluids, electrorheological fluids, and magnetorheological (MR) fluids. In the paper, magnetorheological fluids are considered for use in a spherical actuator for haptic applications. An approach is presented to the design and optimization of such a device, using finite element method modelling linked with differential evolution (DE). Much consideration was given to the construction of the objective function to be minimized. A novel approach to objective function assembly was used, using reference values based on the model design and created with parameters set to the midpoint values of the selected range. It was found to be a useful strategy when the reference values are unknown. There were four parameters to be optimized. Three of them gravitated towards the boundary value, and the fourth (actuator radius) was somewhere in between. The value of the objective function reached a minimum in the range of actuator radius between 42.9880 mm and 45.0831 mm, which is about a 5% difference in regard to the actuator radius. Three passes of optimization were performed with similar results, proving the robustness of the algorithm.
Ključne besede: magnetorheological fluid, finite element method, FEM, optimization, differntial evolution, DE, actuator
Objavljeno v DKUM: 22.05.2024; Ogledov: 173; Prenosov: 22
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5. Extraction of active compounds from mixtures of hemp (Cannabis sativa) with Pants of the Zingiberaceae familyVesna Postružnik, Taja Žitek Makoter, Darko Goričanec, Petra Kotnik, Željko Knez, Maša Knez Marevci, 2023, izvirni znanstveni članek Ključne besede: supercritical fluid extraction, ultrasound-assisted extraction, hemp, ginger, turmeric, cardamom
Objavljeno v DKUM: 08.05.2024; Ogledov: 234; Prenosov: 20
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6. Numerical simulations of the flow and aerosol dispersion in a violent expiratory event : Outcomes of the “2022 International Computational Fluid Dynamics Challenge on violent expiratory eventsJordi Pallares, Alexandre Fabregat Tomas, Akim Lavrinenko, Hadifathul Akmal bin Norshamsudin, Gabor Janiga, David Frederick Fletcher, Kiao Inthavong, Marina Zasimova, Vladimir Ris, Nikolay Ivanov, Robert Castilla, Pedro Javier Gamez-Montero, Gustavo Raush, Hadrien Calmet, Daniel Mira, Jana Wedel, Mitja Štrakl, Jure Ravnik, Douglas Hector Fontes, Francisco José De Souza, Cristian Marchioli, Salvatore Cito, 2023, izvirni znanstveni članek Opis: This paper presents and discusses the results of the “2022 International Computational Fluid Dynamics Challenge on violent expiratory events” aimed at assessing the ability of different computational codes and turbulence models to reproduce the flow generated by a rapid prototypical exhalation and the dispersion of the aerosol cloud it produces. Given a common flow configuration, a total of 7 research teams from different countries have performed a total of 11 numerical simulations of the flow dispersion by solving the Unsteady Reynolds Averaged Navier–Stokes (URANS) or using the Large-Eddy Simulations (LES) or hybrid (URANS-LES) techniques. The results of each team have been compared with each other and assessed against a Direct Numerical Simulation (DNS) of the exact same flow. The DNS results are used as reference solution to determine the deviation of each modeling approach. The dispersion of both evaporative and non-evaporative particle clouds has been considered in 12 simulations using URANS and LES. Most of the models predict reasonably well the shape and the horizontal and vertical ranges of the buoyant thermal cloud generated by the warm exhalation into an initially quiescent colder ambient. However, the vertical turbulent mixing is generally underpredicted, especially by the URANS-based simulations, independently of the specific turbulence model used (and only to a lesser extent by LES). In comparison to DNS, both approaches are found to overpredict the horizontal range covered by the small particle cloud that tends to remain afloat within the thermal cloud well after the flow injection has ceased.
Ključne besede: numerical simulations, computational fluid dynamics
Objavljeno v DKUM: 28.03.2024; Ogledov: 456; Prenosov: 464
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7. Ionic hydraulic fluids and seal-material compatibilityDarko Lovrec, Roland Kalb, Vito Tič, 2024, izvirni znanstveni članek Opis: Manufacturers of hydraulic fluids invest a lot of effort and resources in improving their physico-chemical properties, with the goal of getting as close as possible to the properties of an ideal hydraulic fluid. It should be non- flammable, environmentally friendly, sustainable and should have excellent physical and chemical properties. After decades of development in the field of ionic liquids and the search for an ionic liquid suitable for use in hydraulic systems, ionic hydraulic liquids are now already in industrial use, especially on devices that operate in harsh and risky operating conditions. Since ionic hydraulic fluids are a completely new type of hydraulic fluid, one of the issues is their compatibility with the materials present in the hydraulic components, including all the seals. This paper refers to the process of testing the compatibility of hydraulic seal materials with different types of ionic hydraulic fluids according to the standardized percentages and recommendations, with emphasis on changes in the swell, shrinkage and hardness of the seals. The presented results are a useful guide for selecting suitable seal materials in case of using high-tech ionic hydraulic fluids.
Ključne besede: ionic hydraulic fluids, seal material, compatibility, fluid-testing method, test results
Objavljeno v DKUM: 19.03.2024; Ogledov: 287; Prenosov: 26
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8. Numerical analysis of a wind turbine blade with different softwareGorazd Hren, 2019, izvirni znanstveni članek Opis: The development of wind power generation technology recognises the wind turbine blade design and manufacturing as crucial for its performance. The laboratory size wind turbine blade was analysed, considering the 3D printing plastic material for blades. Applying the structural dynamic equations of blades, the aero-elastic model of the rotating rotor and the numerical simulation method of the deflections are presented under the aerodynamic loads and centrifugal forces. Based on the parameters of aerofoil and the geometrical parameters of blade, 3D model of the blade was established with the modelling software. Then the model was introduced into computational flow dynamics software to carry out the loads on the blade and further into numerical structural analysis. The analysis was performed in two different software packages. Design of wind turbine blades depends on high precision, reliable and robust numerical predictions of performance where the plug-in software is found to be inadequate for nontrivial problems.
Ključne besede: computational fluid dynamics, numerical analysis, structural analysis, wind turbine blade
Objavljeno v DKUM: 22.02.2024; Ogledov: 332; Prenosov: 62
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9. Reconstruction of a fluid bed device for separating granular material from the grinding process of rapid antigen testsMiha Jordan, Tilen Švarc, Peter Majerič, Rebeka Rudolf, Matej Zadravec, 2023, izvirni znanstveni članek Opis: The article includes the study and reconstruction of a fluid bed device with the purpose of separating the granular material from the grinding process of rapid antigen tests. The following techniques were performed, with the purpose of characterisation of the ground particles: sieve analysis, X-ray fluorescence spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy and transmission electron microscopy. The paper includes experimental testing of a simplified separation process with zeolite spheres and paper strips, supported by a numerical model. The flow conditions’ impact on the behaviour and interactions of particles of the considered problem were simulated using coupled computational fluid dynamics (CFD) and the discrete element method (DEM) approach. The separation process of zeolite spheres and paper strips was found to be efficient. The simulation results showed the appropriate behaviour of the particles during the process. We explained the results’ deviations, and we also presented the shortcomings and possible improvements. Further research is required to define the adequacy of the process, while using actual ground material of rapid antigen tests.
Ključne besede: rapid antigen tests, nanomaterials, fluidised bed, computational fluid dynamics, discrete element method, characterisation
Objavljeno v DKUM: 05.01.2024; Ogledov: 378; Prenosov: 57
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