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The consolidation of emulsion templating and thiol-ene click chemistry as a route to degradable polyhipes for biomedical applications : doktorska disertacija
Viola Hobiger, 2022, doktorska disertacija

Opis: Thiol-ene click chemistry has been on the rise for the past two decades. In the past years, it has also found its way into the synthesis of porous polymers from emulsion templating (polyHIPEs) due to its versatility and convenience. It is an especially attractive pathway for scaffolds intended for biomedical purposes since the resulting materials are often biocompatible and degradable due to hydrolyzable ester bonds introduced via the thiol monomers. The overall aim of this dissertation was to bring thiol-ene click chemistry with a focus on photopolymerization to the forefront of polyHIPE research, highlighting the great potential in combining the preparation technique of emulsion templating together with thiol-ene click chemistry. A study to understand the mechanisms of emulsion stability with a focus on already established thiol-ene formulations was conducted. It was possible to study and synthesize materials with a bicontinuous pore morphology within this project. Compared to the typical cellular pore morphology of a polyHIPE, a bicontinuous structure could be especially useful for separation applications. Furthermore, it was possible to induce a phase inversion, leading to small polymer particles. One part of the dissertation focused on synthesizing hydrophilic polyHIPEs from poly(ethylene glycol) monomers and a hydrophilic thiol through an oil-in-water high internal phase emulsion. The resulting materials exhibited high porosity and small average pore diameters of 2.2 µm. Water uptake and degradation studies were performed. The potential of the material for drug release was demonstrated with the chosen model drug salicylic acid. Furthermore, a HIPE formulation based on the acrylate 1,6-hexanediol diacrylate and thiol tris[(3-mercaptopropionyloxy)-ethyl]-isocyanurate was developed. For the developed poly(acrylate-co-thiol) polyHIPEs, the effect of oxidation thioethers present in the polymer network on the material properties was explored. This investigation was performed firstly to tune material properties, e.g. increase the glass transition temperature and tensile strength, and secondly, to highlight the oxidation properties of thioether-containing polymer networks. The oxidation responsiveness should be considered when a biomedical application is envisioned since inflammatory processes lead to oxidative stress in an organism. The formulation was also investigated for its additive manufacturing potential. The emulsion composition had to be adjusted to obtain a printable emulsion. Furthermore, it was possible to exclude harmful solvents, making the overall printing process more environmentally friendly and less hazardous for operators. A polyHIPE from the biobased vinyl ester O,O‘-(hexahydrofuro[3,2-b]furan-3,6-diyl) divinyl diadipate (GDVA), which was especially promising as a biocompatible and biodegradable scaffold for tissue engineering, was prepared together with different thiol chain-transfer agents. The synthesis of cellular interconnected polyHIPEs from these starting materials proved challenging. However, the first synthesis of a biobased vinyl ester polyHIPE could be reported. A final project was conducted in collaboration with Lithoz GmbH. In collaboration, it was possible to establish the first 3D printed ceramics from high internal phase emulsion precursors. For this purpose, trimethylolpropantriacrylte and the thiol trimethylolpropane tris(3-mercaptopropionate) were employed as monomers together with alumina particles to form a composite polyHIPE which would then be submitted to sintering, resulting in an intrinsically porous printed ceramic, allowing for high customization and complex porous morphologies.
Ključne besede: polyHIPE, thiol-ene, photopolymerization, additive manufacturing
Objavljeno v DKUM: 07.10.2022; Ogledov: 587; Prenosov: 97
.pdf Celotno besedilo (12,79 MB)

Porous beads from multiple emulsions with thiol-ene polymerisation : magistrsko delo
Stanko Kramer, 2019, magistrsko delo

Opis: This thesis aims to explain the process of porous bead synthesis. The porous beads were prepared from a multiple emulsion water-in-oil-in-water (W/OW) system. The W/O/W multiple emulsion was made up of a High Internal Phase Emulsion (HIPE (primary emulsion)) and a suspension phase. The HIPE consisted of pentaerythritol tetrakis (3 mercaptopropionate) (TT) in combination with either divinyl adipate (DVA) or trimethylolpropane triacrylate (TMPTA) and an internal phase volume fraction of 80 %. The suspension phase consisted of an aqueous phase with dissolved surfactants which stabilised the secondary emulsion. The surfactants which stabilised the secondary emulsion were polyvinylpyrrolidone K30 (PVP K30) and polyvinylpyrrolidone K90 (PVP K90). The polymerisation was carried out thermally at first for 24 hours and later under UV light and daylight, as the thermally initiated polymerisation was unsuccessful due to coalesence. The beads that were obtained using the photoinitiated polymerisation were porous with a mostly bicontinuous structure and varying diameters. The viscosity of the primary emulsion (HIPE) had the greatest influence on the stability of the entire W/O/W emulsion. By adding more than 5 wt. % of toluene to the primary emulsion, the emulsion broke down and did not successfully polymerise. Another important factor was the ratio of the functional groups in the case of TT-co-TMPTA, which greatly affected the yield and structure of the obtained beads. The diameters of the spherical particles were dependent on the viscosity, monomer ratio and surfactant used in the suspension phase. The inner structure of the beads was mostly bicontinuous with occasional pores that resembled a polyHIPE structure. The obtained beads had a yield of up to 80 % in the case of TT-co-DVA and a yield of up to 90 % in the case of TMPTA-co-DVA
Ključne besede: polyHIPE, thiol-ene, suspension polymerisation, porous beads, HIPE
Objavljeno v DKUM: 17.09.2019; Ogledov: 1431; Prenosov: 216
.pdf Celotno besedilo (3,56 MB)

2014, doktorska disertacija

Opis: Cobalt ferrite (CoFe2O4) nanoparticles prepared via co-precipitation method were modified with tetraethoxysilane (TEOS) and additional funkcionalized with 3-mercaptopropyl trimethoxysilane (MPTMS) with purpose of cleaning waste water contaminated with heavy metal ions (Pb2+ and Hg2+). The influence of different experimental parameters (reaction time, reaction temperature and different TEOS:MPTMS ratios) on silica coating of CoFe2O4 nanoparticles and additional on thiol group was systematically studied. Silanes adsorb to the particle surface with alkoxy (Si(OR)4) groups at one end, while functional substituents (-SH) at the opposite end stay extended into surrounding aqueous medium and chemically interact with heavy metal contaminates. Thiol functionalized CoFe2O4 nanoparticles were characterized using IR spectroscopy, X-ray diffraction (XRD), transmission electron microscopy/high-resolution transmission electron microscopy (TEM/HRTEM), energy-dispersive X-ray spectroscopy (EDXS) and vibrating-sample magnetometer (VSM). The thiol functionalized CoFe2O4 nanoparticles were used for Pb2+ and Hg2+ions adsorption from aqueous media. Effect of treatment has been demonstrated using atomic absorption spectroscopy (AAS).
Ključne besede: cobalt ferrite, magnetic nanoparticles, tetraethoxysilane, 3-mercaptopropyl trimetoxysilane, thiol group, lead, mercury, adsorption
Objavljeno v DKUM: 02.12.2014; Ogledov: 2990; Prenosov: 206
.pdf Celotno besedilo (5,22 MB)

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