1. Water uptake, thin-film characterization, and gravimetric pH-sensing of poly(vinylphosphonate)-based hydrogelsAnton S. Maier, Matjaž Finšgar, Beatrice De Chiara, Rupert Kargl, Bernhard Wolfrum, Karin Stana-Kleinschek, Bernhard Rieger, 2024, izvirni znanstveni članek Ključne besede: superabsorbent hydrogels, pH-responsiveness, hydrogel thin films, quartz crystal microbalance, pH sensor, reversible swelling
Objavljeno v DKUM: 08.01.2025; Ogledov: 0; Prenosov: 4
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2. Investigating the viability of epithelial cells on polymer based thin-filmsBoštjan Vihar, Jan Rožanc, Boštjan Krajnc, Lidija Gradišnik, Marko Milojević, Laura Činč Ćurić, Uroš Maver, 2021, izvirni znanstveni članek Opis: The development of novel polymer-based materials opens up possibilities for several novel applications, such as advanced wound dressings, bioinks for 3D biofabrication, drug delivery systems, etc. The aim of this study was to evaluate the viability of vascular and intestinal epithelial cells on different polymers as a selection procedure for more advanced cell-polymer applications. In addition, possible correlations between increased cell viability and material properties were investigated. Twelve polymers were selected, and thin films were prepared by dissolution and spin coating on silicon wafers. The prepared thin films were structurally characterized by Fourier transform infrared spectroscopy, atomic force microscopy, and goniometry. Their biocompatibility was determined using two epithelial cell lines (human umbilical vein endothelial cells and human intestinal epithelial cells), assessing the metabolic activity, cell density, and morphology. The tested cell lines showed different preferences regarding the culture substrate. No clear correlation was found between viability and individual substrate characteristics, suggesting that complex synergistic effects may play an important role in substrate design. These results show that a systematic approach is required to compare the biocompatibility of simple cell culture substrates as well as more complex applications (e.g., bioinks).
Ključne besede: HUIEC, HUVEC, morphology, polymers, thin films, viability
Objavljeno v DKUM: 18.10.2024; Ogledov: 0; Prenosov: 1
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3. Novel methacrylate-based multilayer nanofilms with incorporated FePt-based nanoparticles and the anticancer drug 5-fluorouracil for skin cancer treatmentKristijan Skok, Tanja Zidarič, Kristjan Orthaber, Matevž Pristovnik, Nina Kostevšek, Kristina Žužek Rožman, Sašo Šturm, Lidija Gradišnik, Uroš Maver, Tina Maver, 2022, izvirni znanstveni članek Opis: Despite medical advances, skin-associated disorders continue to pose a unique challenge to physicians worldwide. Skin cancer is one of the most common forms of cancer, with more than one million new cases reported each year. Currently, surgical excision is its primary treatment; however, this can be impractical or even contradictory in certain situations. An interesting potential alternative could lie in topical treatment solutions. The goal of our study was to develop novel multilayer nanofilms consisting of a combination of polyhydroxyethyl methacrylate (PHEMA), polyhydroxypropyl methacrylate (PHPMA), sodium deoxycholate (NaDOC) with incorporated superparamagnetic iron–platinum nanoparticles (FePt NPs), and the potent anticancer drug (5-fluorouracil), for theranostic skin cancer treatment. All multilayer systems were prepared by spin-coating and characterised by atomic force microscopy, infrared spectroscopy, and contact angle measurement. The magnetic properties of the incorporated FePt NPs were evaluated using magnetisation measurement, while their size was determined using transmission electron microscopy (TEM). Drug release performance was tested in vitro, and formulation safety was evaluated on human-skin-derived fibroblasts. Finally, the efficacy for skin cancer treatment was tested on our own basal-cell carcinoma cell line.
Ključne besede: nanomaterials, bimodal therapy, topical skin treatmen, magnetic nanoparticles, thin films, skin cancer, methacrylates
Objavljeno v DKUM: 04.07.2024; Ogledov: 98; Prenosov: 17
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4. Design, Characterisation and Applications of Cellulose-Based Thin Films, Nanofibers and 3D Printed Structures : A Laboratory ManualTanja Pivec, Tamilselvan Mohan, Rupert Kargl, Manja Kurečič, Karin Stana-Kleinschek, 2021, drugo učno gradivo Opis: The introduction of the Laboratory Manual gives the theoretical bases on cellulose and its derivatives, which are used as starting polymers for the preparation of multifunctional polymers with three different advanced techniques - spin coating, electrospinning and 3D printing. In the following, each technique is presented in a separate Lab Exercise. Each exercise covers the theoretical basics on techniques for polymer processing and methods for their characterisation, with an emphasis on the application of prepared materials. The experimental sections contain all the necessary information needed to implement the exercises, while the added results provide students with the help to implement correct and successful exercises and interpret the results.
Ključne besede: multifunctional polymers, polysaccharides, cellulose, electrospun, spin coating, 3D printing, nanofibers, thin films, multifunctional materials, laboratory manuals
Objavljeno v DKUM: 09.03.2021; Ogledov: 965; Prenosov: 25
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5. EXAFS and IR analysis of electrochromic $NiO_x$/$NiO_xH_y$ thin filmsJana Padežnik Gomilšek, Romana Cerc Korošec, Peter Bukovec, Alojz Kodre, 2008, izvirni znanstveni članek Opis: Electrochromic (EC) thin films of $NiO_x$ and $NiO_xH_y$ are prepared by sol-gel method from nickel chloride precursor and deposited onto a suitable substrate by dip-coating technique. The development of the structure with thermal treatment is investigated by EXAFS and IR spectroscopy in two series of films, with high and low concentration of chloride as counter ions. In the former, the predominant structure before thermal treatment is nickel hydroxide. The baking induces condensation, yet with no trace of NiO. In the latter group, colloidal particles are indicated, on which acetate groups are adsorbed or coordinated. At the maximum EC-response the formation of NiO grains is established by EXAFS and IR.
Ključne besede: electrochromism, thin films, nickel oxide, nickel hydroxide, EXAFS
Objavljeno v DKUM: 18.08.2017; Ogledov: 1423; Prenosov: 106
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6. Photoregeneration of trimethylsilyl cellulose as a tool for microstructuring ultrathin cellulose supportsArchim Wolfberger, Rupert Kargl, Thomas Grießer, Stefan Spirk, 2014, izvirni znanstveni članek Opis: Microstructured thin films based on cellulose, the most abundant biopolymer on Earth, have been obtained by UV-irradiation of acid-labile trimethylsilyl cellulose thin films in the presence of N-hydroxynaphtalimide triflate as photoacid generator. We demonstrate that this photoregeneration process can be exploited for the manufacture of cellulose patterns having feature sizes down to 1 μm, with potential applications in life sciences.
Ključne besede: cellulose thin films, cellulose regeneration, patterning of cellulose, photoregeneration
Objavljeno v DKUM: 22.06.2017; Ogledov: 1523; Prenosov: 475
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