1. Kaplan-Meier estimator and survival analysis of unemployment spells in SloveniaAlenka Kavkler, 2024, samostojni znanstveni sestavek ali poglavje v monografski publikaciji Opis: This paper analyses unemployment spells in Slovenia during the Great Recession. Descriptive statistics for several demographic variables are shown and discussed, namely for age group, gender, region, level of education, and work experience. Survival analysis is applied, and the cumulative survival function and the Kaplan-Meier survival function estimator for different levels of education are examined.
Ključne besede: unemployment, survival analysis, Kaplan-Meier estimator
Objavljeno v DKUM: 05.11.2025; Ogledov: 0; Prenosov: 1
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2. International facets of the `chain of survival` for out-of-hospital and in-hospital cardiac arrest : a scoping reviewSebastian Schnaubelt, Koenraad G. Monsieurs, Nino Fijačko, Christoph Veigl, Zehra Al-Hilali, Huba Atiq, Blair L. Bigham, Kathryn Eastwood, Ying-Chih Ko, Tasuku Matsuyama, Justine Athieno Odakha, Alexander Olaussen, Robert Greif, 2024, pregledni znanstveni članek Ključne besede: chain of survival, chainmail of survival, out-of-hospital cardiac arrest, OHCA, cardiopulmonary resuscitation, CPR, scoping review
Objavljeno v DKUM: 19.09.2025; Ogledov: 0; Prenosov: 1
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4. Analyzing resuscitation conference content through the lens of the chain of survivalNino Fijačko, Sebastian Schnaubelt, Vinay Nadkarni, Špela Metličar, Robert Greif, 2025, drugi znanstveni članki Ključne besede: resuscitation science, resuscitation conferences, abstracts, chain of survival, inclusivity, artificial intelligence, machine learning, deep learning
Objavljeno v DKUM: 21.07.2025; Ogledov: 0; Prenosov: 1
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5. Survival camps in nature as a form of social skills trainingMatej Vukovič, 2021, izvirni znanstveni članek Opis: This paper presents survival camps in nature as a form of social skills training. The camps are aimed primarily at adolescents with behavioural and emotional difficulties. They comprise many everyday social skills where both the group and the individual in the group are important. Social skills are among the many skills we teach in survival camps. Participants become acquainted with the content, methods and skills, and they strengthen the competences that help them to better integrate and function in the society. We shall present to what extent and in what way the social skills of young people are strengthened at survival camps, how young people gain vital experiences and competences and develop their potential.
Ključne besede: adolescents, social skills, training, survival, group
Objavljeno v DKUM: 30.06.2025; Ogledov: 0; Prenosov: 14
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6. Ranking as a procedure for selecting a replacement variable in the score predicting the survival of patients treated with curative intent for colorectal liver metastasesIrena Plahuta, Matej Mencinger, Iztok Peruš, Tomislav Magdalenić, Špela Turk, Aleks Brumec, Stojan Potrč, Arpad Ivanecz, 2023, izvirni znanstveni članek Opis: Background and Objectives: The issue of a missing variable precludes the external validation of many prognostic models. For example, the Liverpool score predicts the survival of patients undergoing surgical therapy for colorectal liver metastases, but it includes the neutrophil–lymphocyte ratio, which cannot be measured retrospectively.
Materials and Methods: We aimed to find the most appropriate replacement for the neutrophil–lymphocyte ratio. Survival analysis was performed on data representing 632 liver resections for colorectal liver metastases from 2000 to 2020. Variables associated with the Liverpool score, C-reactive protein, albumins, and fibrinogen were ranked. The rankings were performed in four ways: The first two were based on the Kaplan-Meier method (log-rank statistics and the definite integral ��
between two survival curves). The next method of ranking was based on univariate and multivariate Cox regression analyses.
Results: The ranks were as follows: the radicality of liver resection (rank 1), lymph node infiltration of primary colorectal cancer (rank 2), elevated C-reactive protein (rank 3), the American Society of Anesthesiologists Classification grade (rank 4), the right-sidedness of primary colorectal cancer (rank 5), the multiplicity of colorectal liver metastases (rank 6), the size of colorectal liver metastases (rank 7), albumins (rank 8), and fibrinogen (rank 9).
Conclusions: The ranking methodologies resulted in almost the same ranking order of the variables. Elevated C-reactive protein was ranked highly and can be considered a relevant replacement for the neutrophil–lymphocyte ratio in the Liverpool score. These methods are suitable for ranking variables in similar models for medical research.
Ključne besede: colorectal cancer, liver metastases, inflammation, ranking, survival
Objavljeno v DKUM: 07.04.2025; Ogledov: 0; Prenosov: 9
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7. Factors of hospital mortality in men and women with ST-elevation myocardial infarction - an observational, retrospective, single centre studyMartin Marinšek, David Šuran, Andreja Sinkovič, 2023, izvirni znanstveni članek Opis: Purpose: There are well-known gender differences in mortality of patients with ST-elevation myocardial infarction (STEMI). Our purpose was to assess factors of hospital mortality separately for men and women with STEMI, which are less well known.
Patients and Methods: In 2018– 2019, 485 men and 214 women with STEMI underwent treatment with primary percutaneous coronary intervention (PCI). We retrospectively compared baseline characteristics, treatments and hospital complications between men and women, as well as between nonsurviving and surviving men and women with STEMI.
Results: Primary PCI was performed in 94% of men and 91.1% of women with STEMI, respectively. The in-hospital mortality was significantly higher in women than in men (14% vs 8%, p=0.019). Hospital mortality in both genders was associated significantly to older age, heart failure, prior resuscitation, acute kidney injury, to less likely performed and less successful primary PCI and additionally in men to hospital infection and in women to bleeding. In men and women ≥ 65 years, mortality was similar (13.3% vs 17.8%, p = 0.293).
Conclusion: Factors of hospital mortality were similar in men and women with STEMI, except bleeding was more likely observed in nonsurviving women and infection in nonsurviving men.
Ključne besede: ST-elevation myocardial infarction, female sex, male sex, sex differences, hospital mortality, 30-day survival, 6-month survival
Objavljeno v DKUM: 12.07.2024; Ogledov: 124; Prenosov: 22
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8. Impact of dual dispatch system implementation on response times and survival outcomes in out-of-hospital cardiac arrest in rural areasMatej Strnad, Pia Jerot, Vesna Borovnik Lesjak, 2022, izvirni znanstveni članek Opis: Objectives: Dual dispatch early defibrillation in out-of-hospital cardiac arrest (OHCA) victims provided by firefighters in addition to Emergency medical services (EMS) has proven to increase rate of return of spontaneous circulation (ROSC) and thus survival in the metropolitan or suburban areas whereas the data in rural areas are scarce.
Methods: This was a retrospective observational cohort study of EMS resuscitated OHCA victims in regions with dual dispatch of volunteer firefighters as first responders (intervention group). Historical group was based on all OHCAs occurring in these regions before the implementation of first responders (EMS response only). Multivariate logistic regression with following variables: intervention, age, gender, witnessed status, bystander cardiopulmonary resuscitation (CPR), first rhythm and etiology were used to control for confounding factors affecting ROSC.
Results: A total of 312 OHCAs were included in the study (historical group, n = 115 and intervention group, n = 197). Median time to arrival of first help shortened significantly for all patients, patients with ROSC and patients with Cerebral Performance Category 1/2 (CPC 1/2) in intervention vs historical group (8 vs 12 min, p < 0.001; 7.5 vs 11 min, p = 0.002; 7 vs 10 min, p = 0.011; respectively). The proportion of patients with ROSC, 30-day survival and CPC 1/2 at hospital discharge remained unchanged in intervention vs historical group (21% vs 23%, p = 0.808; 7% vs 6%, p = 0.914; 6% vs 3%, p = 0.442; respectively). The logistic regression model of adjustment confirms the absence of improvement in the ROSC rate after the implementation of first responders.
Conclusions: Introduction of a dual dispatch of local first responders in addition to EMS in cases of OHCA significantly shortened response times. However, reduced response times were not associated with better survival outcomes.
Ključne besede: automated external defibrillator, out-of-hospital cardiac arrest, first responder, survival rate, sudden cardiac death, cardiopulmonary resuscitation, firefighters
Objavljeno v DKUM: 12.07.2024; Ogledov: 105; Prenosov: 26
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9. Association of circulating tumor cells, megakaryocytes and a high immune-inflammatory environment in metastatic breast cancerCvetka Grašič-Kuhar, Silvester Jernej, Marina Mencinger, Tanja Ovčariček, Maja Čemažar, Simona Miceska, Živa Modic, Anamarija Kuhar, Tanja Jesenko, Veronika Kloboves-Prevodnik, 2023, izvirni znanstveni članek Opis: Liquid biopsy is becoming an important source of new biomarkers during the treatment of metastatic cancer patients. Using size-based microfluid technology, we isolated circulating tumor cells (CTCs) from metastatic breast cancer patients to evaluate their presence and cluster formation, as well as the presence of megakaryocytes and immune-inflammatory blood cells, and to correlate their presence with clinicopathological data and overall survival (OS). In total, 59 patients (median age 60.4 years) were included in the study: 62.7% luminal A/B-like, 20.3% HER2-positive, and 17% triple-negative. Our results showed that at least one CTC was present in 79.7% and ≥5 CTCs in 35.2% of the patients. CTC clusters were present in patients with ≥5 CTCs only (in 19.2% of them), and megakaryocytes were present in 52% of all patients. The presence of CTC clusters and megakaryocytes was positively associated with the CTC count. Patients with low pan-inflammatory value (PIV), low systemic immune-inflammatory index (SII), and low relative change from baseline (ΔPIV%, ΔSII%) were associated with significantly higher OS than their counterparts. ΔPIV%, the presence of infection in the last month, and a long duration of metastatic disease were identified as independent prognostic factors for OS. The interplay of CTCs, CTC clusters, megakaryocytes, and PIV needs to be further explored.
Ključne besede: breast cancer, circulating tumor cell, cluster, megakaryocyte, pan-inflammatory value, overall survival
Objavljeno v DKUM: 19.04.2024; Ogledov: 253; Prenosov: 22
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10. Dual-modular versus single-modular stems for primary total hip arthroplasty : a long-term survival analysisSamo K. Fokter, Nejc Noč, Vesna Levašič, Marko Hanc, Jan Zajc, 2023, izvirni znanstveni članek Opis: Background and Objectives: Increased revision rate of dual-modular (DM) femoral stems in primary total hip arthroplasty (THA) because of modular-neck breakage and adverse local tissue reactions (ALTRs) to additional junction damage products is well established and some designs have been recalled from the market. However, some long-term studies of specific DM stems did not confirm the inferiority of these stems compared to standard single-modular (SM) stems, and a head-to-head comparison THA is missing. The objectives of this multicentre study were to determine the survivorship and complication rates of a common DM stem design compared to a similar SM stem. Materials and Methods: In a time frame from January 2012 to November 2015, a cohort of 807 patients (882 hips) consecutively underwent primary cementless THAs at two orthopaedic centres. 377 hips were treated with a Zweimüller-type DM stem THA system and 505 hips with a similar SM stem THA system, both including a modern press-fit acetabulum. Kaplan-Meier survivorship and complication rates were compared between both groups in a median follow-up of 9.0 years (maximum, 9.9 years). Results: The 9-year survivorship of the DM stem THA system (92.6%, 95% CI 89.9–95.3) was significantly lower than that of the SM stem THA system (97.0%, 95% CI 95.2–98.8). There were no differences in revision rates for septic loosening, dislocation, and periprosthetic fractures between the two groups. One ceramic inlay and one Ti-alloy modular neck breakage occurred in the DM stem THA system group, but the main reason for revision in this group was aseptic loosening of components. Conclusions: The survivorship of the DM stem THA system was lower than the similar SM stem THA system in a comparable clinical environment with long-term follow-up. Our results confirmed that no rationale for stem modularity exists in primary THAs.
Ključne besede: total hip arthroplasty, modular necks, exchangeable necks, survival rate, complications, revision rate, primary hip replacement, prosthesis, Ti-alloy
Objavljeno v DKUM: 18.03.2024; Ogledov: 320; Prenosov: 9
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