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Platelet-rich plasma, especially when combined with a TGF-ß inhibitor promotes proliferation, viability and myogenic differentiation of myoblasts in vitro
Robi Kelc, Martin Trapečar, Lidija Gradišnik, Marjan Rupnik, Matjaž Vogrin, 2015, izvirni znanstveni članek

Opis: Regeneration of skeletal muscle after injury is limited by scar formation, slow healing time and a high recurrence rate. A therapy based on platelet-rich plasma (PRP) has become a promising lead for tendon and ligament injuries in recent years, however concerns have been raised that PRP-derived TGF-β could contribute to fibrotic remodelling in skeletal muscle after injury. Due to the lack of scientific grounds for a PRP -based muscle regeneration therapy, we have designed a study using human myogenic progenitors and evaluated the potential of PRP alone and in combination with decorin (a TGF-β inhibitor), to alter myoblast proliferation, metabolic activity, cytokine profile and expression of myogenic regulatory factors (MRFs). Advanced imaging multicolor single-cell analysis enabled us to create a valuable picture on the ratio of quiescent, activated and terminally committed myoblasts in treated versus control cell populations. Finally high-resolution confocal microscopy validated the potential of PRP and decorin to stimulate the formation of polynucleated myotubules. PRP was shown to down-regulate fibrotic cytokines, increase cell viability and proliferation, enhance the expression of MRFs, and contribute to a significant myogenic shift during differentiation. When combined with decorin further synergistc effects were identified. These results suggest that PRP could not only prevent fibrosis but could also stimulate muscle commitment, especially when combined with a TGF-β inhibitor.
Ključne besede: muscles, skeletal, injuries, TGF-beta, plasma, thrombocytes, myoblasts, fibrosis, prevention, regeneration
Objavljeno: 19.06.2017; Ogledov: 38; Prenosov: 0
.pdf Polno besedilo (2,07 MB)

Lower correlation between biceps femoris contraction time and maximal running speed in children than in adults
Jernej Završnik, Rado Pišot, Tadeja Volmut, Katja Koren, Helena Blažun, Peter Kokol, Janez Vošner, Boštjan Šimunič, 2016, izvirni znanstveni članek

Opis: Biceps femoris is a major propulsor muscle in sprinting and its contraction time negatively correlates to the running speeds of adults. Our aim was to compare age and gender-related correlations between vastus lateralis and biceps femoris contraction times and running speeds during a longitudinal study of 9- to 14-year old children. On a yearly basis we conducted vastus lateralis and biceps femoris tensiomyographic measurements of muscle contraction time and maximal running speeds measured during 7 meter sprints with flying starts using photocells in 107 children (53 boys). Vastus lateralis contraction time was not correlated with the running speed. However, biceps femoris contraction time was negatively correlated with the running speed only in boys after the age of 12.9 years (Pearson r ranges from -0.391 to -0.426; p < 0.002). It was concluded that biceps femoris contraction time is far less correlated with running speed than in adult athletes (Pearson r = -0.60); however, the correlation is gender and age-specific. It seems that the knee flexor and hip extensor, biceps femoris, is not as yet the major determinant of running speed in 9- to 14-year old children at that age.
Ključne besede: skeletal muscles, biceps femoris, vastus lateralis, tensiomyography, pediatrics
Objavljeno: 21.07.2017; Ogledov: 82; Prenosov: 1
.pdf Polno besedilo (604,33 KB)

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