Iskanje po katalogu digitalne knjižnice

Opis: Since the discovery of the first nanoparticles, scientists have developed controlled-release drugs, in which nanoparticles play a crucial role as drug carriers. Nanoparticles enable targeted and controlled release, but also face some challenges in their application, production and storage in vivo. The most used nanoparticles for drug encapsulation are liposomes. Liposomes consist of a lipid bilayer membrane that separates the inner hydrophilic/aqueous core from the surrounding environment. In the process known as encapsulation, an active ingredient is added that is either hydrophobic or hydrophilic. Their production is a challenge. Therefore, various production methods have been developed (thin film hydration, reverse phase evaporation, microfluidic methods, etc.) to achieve high encapsulation efficiency, stability and improved drug delivery in vivo. In medical treatment, liposomes are already used as carriers for analgesics, drugs to prevent and treat a variety of diseases (fungal, bacterial, and viral infections) and chemotherapeutics to treat various types of cancer (docetaxel, paclitaxel, doxorubicin, etc.). This article gives an insight into the methods of liposome production, ranging from conventional to more modern techniques with their advantages and disadvantages of the encapsulated substances and their use in medicine.
Ključne besede: nanoparticles, drug delivery, liposome preparation methods, liposome applications, medical substances, nanodelci, prenos zdravil, liposomi, medicinske sestavine
Objavljeno v DKUM: 06.11.2025; Ogledov: 0; Prenosov: 9
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Opis: The role of NIMBY (“Not in My Backyard”) phenomena in sustainable urban development and tourism was analyzed, with a focus on stakeholder dynamics and implications for spatial planning. Based on an analysis of worldwide case studies, the main barriers and opportunities presented by these phenomena were identified, including the impact of project preparation time (tp) and benefit realization time (tb ). A mixed methods approach was used, combining qualitative analysis of case studies with quantitative evaluation of project timelines. The results show that effective stakeholder engagement significantly reduces tp, while maximizing tb increases long-term benefits for communities and the environment. This research emphasizes the systemic interdependence of urban planning, environmental sustainability, tourism, and cultural heritage preservation, offering actionable insights for policymakers and developers. The conclusions emphasize the importance of participatory approaches to ensure equitable and sustainable urban transformation.
Ključne besede: NIMBY, spatial planning, sustainable urban development, sustainable tourism, maintenance, cultural heritage, tourism impact, project preparation, (negative) indirect benefit
Objavljeno v DKUM: 02.04.2025; Ogledov: 0; Prenosov: 3
Celotno besedilo (2,10 MB)
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Opis: The fabrication of nanocellulose-based substrates with high dielectric permittivity and anisotropic thermal conductivity to replace synthetic thermoplastics in flexible organic electronics remains a big challenge. Herein, films were prepared from native (CNF) and carboxylated (TCNF) cellulose nanofibrils, with and without the addition of thermally conductive multi-layered Ti3C2Tx MXene, to examine the impact of polar (− OH, − COOH) surface groups on the film morphological, moisturizing, dielectric, and thermal dissipation properties. The electrostatic repulsion and hydrogen bonding interaction between the hydrophilic surface/terminal groups on CNF/TCNF and MXene was shown to render their self-assembly distribution and organization into morphologically differently structured films, and, consequently, different properties. The pristine CNF film achieved high intrinsic dielectric permittivity (ε' ~ 9), which was further increased to almost ε' ~ 14 by increasing (50 wt%) the MXene content. The well-packed and aligned structure of thinner TCNF films enables the tuning of both the composite’s dielectric permittivity (ε' ~ 6) and through-plane thermal conductivity (K ~ 2.9 W/mK), which increased strongly (ε' ~ 17) at higher MXene loading giving in-plane thermal conductivity of ~ 6.3 W/mK. The air-absorbed moisture ability of the films contributes to heat dissipation by releasing it. The dielectric losses remained below 0.1 in all the composite films, showing their potential for application in electronics.
Ključne besede: nanofibrillated cellulose, Ti3C2T, Mxene, film preparation, moisture content, thermal conductivity
Objavljeno v DKUM: 03.09.2024; Ogledov: 36; Prenosov: 18
Celotno besedilo (1,87 MB)
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Ključne besede: optical sensor layers preparation, spin coating, spray coating, inkjet printing, SFE, XPS, NH3, response, real-time response
Objavljeno v DKUM: 28.03.2024; Ogledov: 198; Prenosov: 15
Celotno besedilo (3,43 MB)
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Opis: The preparation and usability of a sulphide ion selective electrode, prepared by means of chemical pretreatment of silver wire with an ammonium perdisulphate solution, and the sulphidization in an alkaline sulphide solution are described. The electrode is suitable for direct potentiometric measuring of sulphide in alkaline solutions of concentrations down to ▫$1 X 10^{-6} mol/L$▫. The 45 min required for each chemical treatment are enough for the preparation of the described electrode.
Ključne besede: analytical chemistry, ion selective electrode, preparation, silver wire, potentiometric measurements, sulphide ions
Objavljeno v DKUM: 17.08.2017; Ogledov: 1403; Prenosov: 149
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