1. UCHL1, besides leptin and fibronectin, also could be a sensitive marker of the relapsing–remitting type of multiple sclerosisEwelina Görska, Marzena Tylicka, Adam Hermanowicz, Ewa Matuszczak, Anna Sankiewicz, Ewa Gorodkiewicz, Justyna Hermanowicz, Elźbieta Karpińska, Katarzyna Socha, Jan Kochanowicz, Evgenija Homšak, 2023, izvirni znanstveni članek Opis: Research on the markers of immunoregulatory response in multiple sclerosis (MS) is still of great importance. The aim of our study was the evaluation of leptin, fibronectin, and UCHL1 concentrations as potential biomarkers of a relapsing-remitting type of MS (RRMS). Surface Plasmon Resonance Imaging (SPRI) biosensors were used for the evaluation of proteins concentrations in 100 RRMS patients and 46 healthy volunteers. Plasma leptin, fibronectin, and UCHL1 concentrations were significantly higher in RRMS patients compared to the control group (p < 0.001, respectively). UCHL1 concentration evaluation revealed the highest diagnostic sensitivity (100%) and negative predictive value (100%) in differentiating MS patients from healthy individuals. There was no significant difference in the UCHL1 concentrations depending on the patient's sex, the presence of relapse within the last 24 months, and the EDSS value (p > 0.05, respectively). In RRMS patients UCHL1 concentration positively correlated with fibronectin levels (r = 0.3928; p < 0.001). In the current cohort of patients plasma UCHL1 concentration was independent of the time of MS relapse and the severity of neurological symptoms. Thus current study may indicate that plasma UCHL1, besides leptin and fibronectin, also could be a promising high-sensitive potential biomarker of relapsing-remitting type of MS. However, these results should be validated with a larger group of patients, taking into account neuroimaging and cerebrospinal fluid analysis data, and by comparing them to patients with other neurological diseases as a control group.
Ključne besede: immunoregulatory response, multiple sclerosis, biomarkers, leptin, fibronectins, ubiquitin thiolesterase
Objavljeno v DKUM: 21.02.2024; Ogledov: 281; Prenosov: 18
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3. Diagnostic relevance of free light chain indices and their relation to the clinical presentation of multiple sclerosisSanja Karakatič, Jožef Magdič, Sašo Karakatič, Tomaž Omerzu, Evgenija Modrič, Tanja Hojs-Fabjan, 2020, izvirni znanstveni članek Ključne besede: multiple sclerosis, free light chains, kappa index, lambda index, functional systems, EDSS score
Objavljeno v DKUM: 24.01.2023; Ogledov: 677; Prenosov: 72
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4. Impact of multiple sclerosis on infertility and impact of infertility treatments on multiple sclerosis relapses in Slovenia : medical outline, legal and ethical outcomesEda Vrtačnik-Bokal, Urban Vrtačnik, 2020, izvirni znanstveni članek Opis: Multiple sclerosis (MS) is an autoimmune inflammatory disorder of the central nervous system. It is common in the reproductive period and can lead to infertility and significant disability. The treatment on multiple sclerosis is recently more successful and enables better quality of life, therefore rising hope and desire for the future parents, also in terms of successful infertility treatments. In this context the couples should be managed concerning the detrimental effect of the disease itself on fertility, detrimental effect of the drugs used for treatment on gonads and in terms of the implementation of drugs used for ovarian stimulation and their impact on the basic disease (MS). Article finds solutions on the legal outcomes in situations where infertility treatments may negatively impact the progress of MS, as well as the solutions on how to (successfully) provide infertility treatments to the patients with MS. It proposes interdisciplinary approach between gynecologists and neurologists to perform required weighting of benefits and risks (burdens), deriving from specific action or treatment, whereas for the patients who shall not undergo infertility treatments due to their medical status, related to MS, it proposes storage of gametes under conditions, set by the law.
Ključne besede: multiple sclerosis, infertility, in vitro fertilization, MAR, ZZNPOB, ZPacP, medical ethics
Objavljeno v DKUM: 15.01.2021; Ogledov: 706; Prenosov: 38
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