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1.
Wosc - a loosely connected network of people and organisations with common goals : the purpose of interactions
Igor Perko, 2024, samostojni znanstveni sestavek ali poglavje v monografski publikaciji

Ključne besede: wosc, Systems thinking, Cybernetics, non-organisation, interactions, structures
Objavljeno v DKUM: 06.11.2025; Ogledov: 0; Prenosov: 0
.pdf Celotno besedilo (924,50 KB)

2.
Routine and ritual small talk in Chinese rural shops
Dániel Z. Kádár, Yilin Chai, Juliane House, 2025, izvirni znanstveni članek

Opis: In this study, we propose an integrative approach to Small Talk by bringing together routine and ritual, and also by approaching Small Talk through the lens of ritual, speech acts and discourse. Routine manifestations of Small Talk include banal phatic interaction, such as weather talk which follows conventionalised patterns, has limited bonding ca pacity and no deeper meaning. Ritual Small Talk, on the other hand, refers to phatic interaction which also follows conventionalised patterns but has a deeper purpose and meaning, and has a more lasting bonding capacity. We analyse a corpus featuring shop talk in a rural Chinese town, hence filling a knowledge since Small Talk in rural settings has been understudied. We conduct a bipartite analysis, i.e. we first consider how in teractions in our corpus tend to be opened and closed, and then we analyse our data through Small Talk themes. Our analysis shows that in Chinese rural shops routines do not simply dissolve when the participants become more familiar, but rather they transform into ritual. This finding shows that Small Talk in the setting studied operates differently from what has been observed in urbanised contexts.
Ključne besede: applied linguistics, Chinese, English, small talk, routine, interactions, ritual, rapport, rural shops, China
Objavljeno v DKUM: 26.09.2025; Ogledov: 0; Prenosov: 1
.pdf Celotno besedilo (737,42 KB)
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3.
Assessing acute pancreatitis : a novel method combining live cell imaging with tissue damage evaluation
Polona Kovačič, Maša Skelin, Eva Paradiž, Viktória Venglovecz, Loránd Kiss, Gabriella Mihalekné Fűr, Andraž Stožer, Jurij Dolenšek, 2025, izvirni znanstveni članek

Opis: Acute pancreatitis (AP) is a sudden inflammation of the exocrine part of the pancreas, resulting in self-digestion and destruction of exocrine tissue. The intricate relationship between exocrine and endocrine functions is pivotal, as damage to acinar cells can affect endocrine cell function and vice versa. However, our understanding of these interactions remains limited. An effective strategy for investigating pancreatic cells involves the utilization of live in-situ acute mouse pancreas tissue slice preparations, combined with noninvasive fluorescent calcium labeling of endocrine or exocrine cells, and subsequent analysis using confocal laser scanning microscopy. Nevertheless, this approach encounters inherent conflicts with conventional methodologies employed to histologically assess the severity of tissue damage due to AP in the model. Traditional methods involve fixing and staining tissue samples with hematoxylin and eosin, thereby precluding live-cell imaging. In this study, our objective was to introduce an innovative method utilizing a commercial fluorescence Live/Dead assay that enables calcium imaging and tissue damage assessment in the same sample. This approach was validated against the classical histological grading of AP severity, and we found a good correlation between the classical histological grading method and the in-situ approach employing the Live/Dead assay. The primary advantage of our novel approach lies in its capacity to enable timely and efficient live-cell imaging together with damage assessment in the same tissue, thereby enabling the study of functional consequences of structural damage at the cellular level and reducing the number of animals required for experimentation.
Ključne besede: acute pancreatitis, pancreatic tissue damage, exocrine and endocrine interactions, live cell imaging, confocal laser scanning microscopy, calcium imaging, live/dead assay, tissue slice preparation, histological grading
Objavljeno v DKUM: 22.08.2025; Ogledov: 0; Prenosov: 5
.pdf Celotno besedilo (17,08 MB)
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4.
Unveiling polyphenol-protein interactions : a comprehensive computational analysis
Samo Lešnik, Marko Jukič, Urban Bren, 2025, izvirni znanstveni članek

Opis: Our study investigates polyphenol-protein interactions, analyzing their structural diversity and dynamic behavior. Analysis of the entire Protein Data Bank reveals diverse polyphenolic structures, engaging in various noncovalent interactions with proteins. Interactions observed across crystal structures among diverse polyphenolic classes reveal similarities, underscoring consistent patterns across a spectrum of structural motifs. On the other hand, molecular dynamics (MD) simulations of polyphenol-protein complexes unveil dynamic binding patterns, highlighting the influx of water molecules into the binding site and underscoring limitations of static crystal structures. Water-mediated interactions emerge as crucial in polyphenol-protein binding, leading to variable binding patterns observed in MD simulations. Comparison of high- and low-resolution crystal structures as starting points for MD simulations demonstrates their robustness, exhibiting consistent dynamics regardless of the quality of the initial structural data. Additionally, the impact of glycosylation on polyphenol binding is explored, revealing its role in modulating interactions with proteins. In contrast to synthetic drugs, polyphenol binding seems to exhibit heightened flexibility, driven by dynamic water-mediated interactions, which may also facilitate their promiscuous binding. Comprehensive dynamic studies are, therefore essential to understand polyphenol-protein recognition mechanisms. Overall, our study provides novel insights into polyphenol-protein interactions, informing future research for harnessing polyphenolic therapeutic potential through rational drug design.
Ključne besede: polyphenols, polyphenol-protein complexes, molecular dynamics simulations, noncovalent interactions, water-mediated interactions, glycosylation, dynamic behavior
Objavljeno v DKUM: 14.08.2025; Ogledov: 0; Prenosov: 3
.pdf Celotno besedilo (5,61 MB)

5.
Prompt engineering for chatbots
Mladen Borovič, 2025, drugo učno gradivo

Ključne besede: artificial intelligence, chatbots, prompt engineering, effective chatbot interactions
Objavljeno v DKUM: 23.06.2025; Ogledov: 0; Prenosov: 55
.pdf Celotno besedilo (1,12 MB)

6.
Collective dynamics of swarmalators with higher-order interactions
Md Sayeed Anwar, Gourab Kumar Sar, Matjaž Perc, Dibakar Ghosh, 2024, izvirni znanstveni članek

Opis: Higher-order interactions shape collective dynamics, but how they affect transitions between different states in swarmalator systems is yet to be determined. To that effect, we here study an analytically tractable swarmalator model that incorporates both pairwise and higher-order interactions, resulting in four distinct collective states: async, phase wave, mixed, and sync states. We show that even a minute fraction of higher-order interactions induces abrupt transitions from the async state to the phase wave and the sync state. We also show that higher-order interactions facilitate an abrupt transition from the phase wave to the sync state bypassing the intermediate mixed state. Moreover, elevated levels of higher-order interactions can sustain the presence of phase wave and sync state, even when pairwise interactions lean towards repulsion. The insights gained from these findings unveil self-organizing processes that hold the potential to explain sudden transitions between various collective states in numerous real-world systems.
Ključne besede: collective dynamics, nonlinear oscillator, higher-order interactions, complex network, statistical physics
Objavljeno v DKUM: 07.05.2025; Ogledov: 0; Prenosov: 2
.pdf Celotno besedilo (2,75 MB)
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7.
Enhancing Martini3 for protein self-interaction simulations
Jonas Binder, Matja Zalar, Martin Huelsmeyer, Michael Siedler, Robin Curtis, Wolfgang Frieß, 2025, izvirni znanstveni članek

Opis: Coarse-grained molecular dynamics simulations are highly valuable for studying protein-protein interactions. Unfortunately, commonly used force fields often overestimate these interactions. Here, we investigate the performance of the Martini 3 force field in predicting the self-interaction behavior of lysozyme and subtilisin using Metadynamics. The original Martini 3, despite improvements over its predecessor, overestimates interaction strength. Through reparameterization of bead interactions, we achieve good agreement with experimental data of the second virial coefficient and the diffusion coefficient. The new, refined force field enables more accurate CG-MD simulations, with potential applications in understanding and prediction of protein stability, aggregation tendencies, and solubility, with the possibility to aid in the development of protein-based drugs.
Ključne besede: coarse-grained molecular dynamics, Martini 3 force field, protein-protein interactions, B22, reparameterization, NMR, diffusion coefficient
Objavljeno v DKUM: 20.03.2025; Ogledov: 0; Prenosov: 7
.pdf Celotno besedilo (6,83 MB)

8.
Hybrid reality development - can social responsibility concepts provide guidance?
Igor Perko, 2021, izvirni znanstveni članek

Opis: Purpose: This paper aims to define hybrid reality (HyR) as an ongoing process in which artificial intelligence (AI) technology is gradually introduced as an active stakeholder by using reasoning to execute real-life activities. Also, to examine the implications of social responsibility (SR) concepts as featured in the HyR underlying common framework to progress towards the redefinition of global society. Design/methodology/approach: A combination of systemic tools is used to examine and assess the development of HyR. The research is based on evolutionary and learning concepts, leading to the new meta-system development. It also builds upon the viable system model and AI, invoking SR as a conceptual framework. The research is conducted by using a new approach: using system dynamics based interactions modelling, the following two models have been proposed. The state-of-the-art HyR interactions model, examined using SR concepts; and a SR concept-based HyR model, examined using a smart vehicle case. Findings: In the HyR model, interaction asymmetry between stakeholders is identified, possibly leading to pathological behaviour and AI technology learning corruption. To resolve these asymmetry issues, an interaction model based on SR concepts is proposed and examined on the example of an autonomous vehicle transport service. The examination results display significant changes in the conceptual understanding of transport services, their utilisation and data-sharing concepts. Research limitations/implications: As the research proposal is theoretical in nature, the projection may not display a fully holistic perspective and can/should be complemented with empirical research results. Practical implications: For researchers, HyR provides a new paradigm and can thereby articulate potential research frameworks. HyR designers can recognise projected development paths and the resources required for the implication of SR concepts. Individuals and organisations should be aware of their not necessarily passive role in HyR and can therefore use the necessary social force to activate their status. Originality/value: For the first time, to the best of the author’s knowledge, the term HyR is openly elaborated and systemically examined by invoking concepts of SR. The proposed model provides an overview of the current and potential states of HyR and examines the gap between them.
Ključne besede: artificial intelligence, social responsibility, systems thinking, cybernetics, hybrid reality, interactions model
Objavljeno v DKUM: 04.02.2025; Ogledov: 0; Prenosov: 243
.pdf Celotno besedilo (796,19 KB)
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9.
Impact of inter-city interactions on disease scaling
Nathalia A. Loureiro, Camilo R. Neto, Jack Sutton, Matjaž Perc, Haroldo V. Ribeiro, 2025, izvirni znanstveni članek

Opis: Inter-city interactions are critical for the transmission of infectious diseases, yet their effects on the scaling of disease cases remain largely underexplored. Here, we use the commuting network as a proxy for inter-city interactions, integrating it with a general scaling framework to describe the incidence of seven infectious diseases across Brazilian cities as a function of population size and the number of commuters. Our models significantly outperform traditional urban scaling approaches, revealing that the relationship between disease cases and a combination of population and commuters varies across diseases and is influenced by both factors. Although most cities exhibit a less-than-proportional increase in disease cases with changes in population and commuters, more-than-proportional responses are also observed across all diseases. Notably, in some small and isolated cities, proportional rises in population and commuters correlate with a reduction in disease cases. These findings suggest that such towns may experience improved health outcomes and socioeconomic conditions as they grow and become more connected. However, as growth and connectivity continue, these gains diminish, eventually giving way to challenges typical of larger urban areas - such as socioeconomic inequality and overcrowding - that facilitate the spread of infectious diseases. Our study underscores the interconnected roles of population size and commuter dynamics in disease incidence while highlighting that changes in population size exert a greater influence on disease cases than variations in the number of commuters.
Ključne besede: complex networks, statistical physics, interactions between cities, disease scaling, social physics
Objavljeno v DKUM: 09.01.2025; Ogledov: 0; Prenosov: 4
.pdf Celotno besedilo (3,94 MB)
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10.
Agonistic interactions between littermates reappear after mixing multiple litters at weaning in pigs
Maja Prevolnik Povše, Nikolina Mesarec, Janko Skok, Dejan Škorjanc, 2021, izvirni znanstveni članek

Opis: Weaning involves mixing of unfamiliar litters and is accompanied by an outbreak of aggression, which is usually attributed to between-litter (BL) interactions. In the present study, we thus focused on post-weaning agonism (fighting and mounting) between littermates (within-litter, WL). Two litters were weaned into two pens separated by an empty pen and connected by narrow passages that were opened 24 h after weaning. WL interactions accounted for 38% and 68% of all fights and mounts, respectively, during a 7-day experimental period. After the passages were opened, not only BL, but also WL interactions increased significantly (by 6- to 7-fold on the first day of mixing). WL fights then gradually decreased, while WL mounts continued to increase. During the experimental period, the proportion of both WL fights and mounts decreased. The majority of WL fights (%80%) and mounts (%65%) occurred in home pens. A significantly higher percentage of draws was found in WL fights (50% of initiator wins and 41% of draws) compared to BL fights (80% of initiator wins and 11% of draws). Results also showed less asymmetry in the body weight of piglets involved in WL interactions. Mixing of litters at weaning was shown to involve not only intense interactions between unfamiliar piglets but also the recurrence of agonistic interactions between littermates, which is something we should keep in mind when pursuing the highest standards of weaner welfare.
Ključne besede: pig, weaning, within-litter interactions, fighting, mounting
Objavljeno v DKUM: 06.12.2024; Ogledov: 0; Prenosov: 15
.pdf Celotno besedilo (1,20 MB)
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