1. Siting of healthcare care facilities based on the purpose of their operation, demographic changes, environmental characteristics, and the impact on public healthMarko Jaušovec, Nande Korpnik, Branko Gabrovec, Vanja Skalicky Klemenčič, 2022, pregledni znanstveni članek Opis: A contemporary approach to the spatial design of healthcare care facilities faces numerous
challenges at the crossroads of multidisciplinary topics of architecture and urbanism, healthcare,
security, and organisational sciences. Due to the unique combination of uses, users and architectural
expression, they are defined as urban nodes. With their inclusion, architects facilitate a better
placing of healthcare facilities, indirectly improving human health. The purpose of the article is
to seek guidelines for the siting of healthcare facilities to provide suitable and equal healthcare to
different social structures, and for the optimal and fair spatial distribution of healthcare services.
The descriptive method was used to review literature on the siting of healthcare facilities based on
the purpose of their operation, demographic changes, environmental characteristics, and the impact
on public health. This method was selected as it facilitates data acquisition from various sources
and a comprehensive understanding of the topic discussed. The results of the research show how
important the impact of the healthcare care facilities siting on human health and the wider social
significance of the topic discussed is. The findings may provide guidelines and proposals for future
spatial decisions.
Ključne besede: healthcare facility location, healthcare facility location modelling, hospital geographic location, healthcare facility location planning, healthcare facility spatial plannin
Objavljeno v DKUM: 13.03.2025; Ogledov: 0; Prenosov: 9
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2. Radiotherapy department supported by an optimization algorithm for scheduling patient appointmentsMarcela Chavez, Silvia Gonzalez, Ruiz Alvaro, Duflot Patrick, Nicolas Jansen, Izidor Mlakar, Umut Arioz, Valentino Šafran, Philippe Kolh, Van Gasteren Marteyn, 2025, izvirni znanstveni članek Opis: Prompt administration of radiotherapy (RT) is one of the most effective treatments against cancer. Eachday, the radiotherapy departments of large hospitals must plan numerous irradiation sessions, con-sidering the availability of human and material resources, such as healthcare professionals and linearaccelerators. With the increasing number of patients suffering from different types of cancers, manuallyestablishing schedules following each patient’s treatment protocols has become an extremely difficultand time-consuming task. We propose an optimization algorithm that automatically schedules andgenerates patient appointments. The model can rearrange fixed appointments to accommodate urgentcases, enabling hospitals to schedule appointments more efficiently. It respects the different treatment Prompt administration of radiotherapy (RT) is one of the most effective treatments against cancer. Eachday, the radiotherapy departments of large hospitals must plan numerous irradiation sessions, con-sidering the availability of human and material resources, such as healthcare professionals and linearaccelerators. With the increasing number of patients suffering from different types of cancers, manuallyestablishing schedules following each patient’s treatment protocols has become an extremely difficultand time-consuming task. We propose an optimization algorithm that automatically schedules andgenerates patient appointments. The model can rearrange fixed appointments to accommodate urgentcases, enabling hospitals to schedule appointments more efficiently. It respects the different treatment.
Ključne besede: appointments, hospital management, optimization algorithm, patient satisfaction, planning, radiotherapy
Objavljeno v DKUM: 25.02.2025; Ogledov: 0; Prenosov: 8
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3. Unlocking the power of socially assistive robotic nurses in hospitals through innovative living lab methodologyUmut Arioz, Božidar Bratina, Izidor Mlakar, Nejc Plohl, Suzana Uran, Igor Robert Roj, Riko Šafarič, Valentino Šafran, 2024, izvirni znanstveni članek Ključne besede: co-creation, stakeholder engagement, socially assistive humanoid robots, living lab, hospital care
Objavljeno v DKUM: 03.02.2025; Ogledov: 0; Prenosov: 7
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4. Neurological outcome in patients after successful resuscitation in out-of-hospital settingsMartin Marinšek, Andreja Sinkovič, David Šuran, 2020, izvirni znanstveni članek Opis: Neurological outcome is an important determinant of death in admitted survivors after out-of-hospital cardiac arrest (OHCA). Studies demonstrated several significant pre-hospital predictors of ischemic brain injury (time to resuscitation, time of resuscitation, and cause of OHCA). Our aim was to evaluate the relationship between post-resuscitation clinical parameters and neurological outcome in OHCA patients, when all recommended therapeutic strategies, including hypothermia, were on board. We retrospectively included consecutive 110 patients, admitted to the medical ICU after successful resuscitation due to OHCA. Neurological outcome was defined by cerebral performance category (CPC) scale I-V. CPC categories I-II defined good neurological outcome and CPC categories III-V severe ischemic brain injury. Therapeutic measures were aimed to achieve optimal circulation and oxygenation, early percutaneous coronary interventions (PCI) in acute coronary syndromes (ACS), and therapeutic hypothermia to improve survival and neurological outcome of OHCA patients. We observed good neurological outcome in 37.2% and severe ischemic brain injury in 62.7% of patients. Severe ischemic brain injury was associated significantly with known pre-hospital data (older age, cause of OHCA, and longer resuscitations), but also with increased admission lactate, in-hospital complications (involuntary muscular contractions/seizures, heart failure, cardiogenic shock, acute kidney injury, and mortality), and inotropic and vasopressor support. Good neurological outcome was associated with early PCI, dual antiplatelet therapy, and better survival. We conclude that in OHCA patients, post-resuscitation early PCI and dual antiplatelet therapy in ACS were significantly associated with good neurological outcome, but severe ischemic brain injury was associated with several in-hospital complications and the need for vasopressor and inotropic support.
Ključne besede: out-of-hospital cardiac arrest, OHCA, ischemic brain injury, resuscitation
Objavljeno v DKUM: 30.01.2025; Ogledov: 0; Prenosov: 4
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5. Clinical pharmacist recommendations in daily interdisciplinary ward rounds at a psychiatric hospital: a retrospective pre-post study on drug-related problems focused in somatic comorbiditiesMatej Štuhec, Anteja Gorjan Gazdag, Zala Čuk, Robert Oravecz, Borjanka Batinic, 2024, izvirni znanstveni članek Opis: Objective: One potential strategy to address inadequate screening for somatic comorbidities among patients with mental disorders is to integrate a clinical pharmacist into the inpatient team for daily interdisciplinary ward rounds. This approach remains under-researched in psychiatric hospitals. This study aimed to evaluate the impact of a clinical pharmacist on drug-related problems (DRPs) during daily ward rounds within an interdisciplinary team in a psychiatric hospital. Methods: A retrospective observational pre-post study was conducted at the Ormož Psychiatric Hospital in Slovenia, including patients treated between 2019 and 2020, during which clinical pharmacists offered recommendations during daily ward rounds. The primary outcomes assessed the difference in the total number of DRPs observed at the time of hospital discharge compared to previous stage, as well as the recommendations and their continuation rate after three months. The secondary outcomes evaluated adherence to treatment guidelines. Results: The study included 186 patients (mean age: 58.1 years, SD=17.0). During ward rounds, 280 recommendations related to DRPs were conducted (1.5 recommendations per patient). Regarding the nature of DRPs, 154 (55.0%) were identified as expressed DRPs, while 127 (45.0%) were deemed potential DRPs. Following pharmacist recommendations, 133 (86.4%) of the expressed DRPs were successfully resolved. The majority of DRPs pertained to treatment effectiveness (N=179, 63.9%), followed by unnecessary treatments (N=86, 30.7%) and patient safety (N=15, 5.4%). Initially, the acceptance rate of recommendations was 88.9% (N=249) at discharge, declining to 63.2% (N=177) three months after discharge. The acceptance rate for somatic conditions at discharge was 87.8% (N=122), declining to 59.0% (N=82) three months after discharge. Adherence to treatment guidelines for somatic comorbidities increased (p < 0.05). Conclusions: The results indicate that this approach led to fewer DRPs, a high rate of acceptance, and better adherence to treatment guidelines. This is the first retrospective pre-post study in the European Union to include this collaboration in daily rounds at psychiatric hospitals, focusing on somatic comorbidities. However, the study also has significant limitations, such as its non-randomized design and short monitoring period, which should be addressed in future research.
Ključne besede: psychiatry, clinical pharmacy, hospital, ward rounds, drug-related problem
Objavljeno v DKUM: 07.01.2025; Ogledov: 0; Prenosov: 7
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6. Ozonation of amoxicillin and ciprofloxacin in model hospital wastewater to increase biotreatabilitySeverina Aleksić, Andreja Žgajnar Gotvajn, Katarina Premzl, Mitja Kolar, Sonja Šostar-Turk, 2021, izvirni znanstveni članek Opis: Amoxicillin (AMX) and Ciprofloxacin (CIP) are antibiotics commonly used in human medicine with high environmental toxicity and poor biodegradability. They have been found in various hospital effluents and groundwater, and their environmental impact is still not fully understood. In this work, we investigated the possibility of treating model wastewaters containing the antibiotics AMX and CIP using ozonation, with the addition of H$_2$O$_2$ under various conditions, including different pH values, H$_2$O$_2$, and ozone dosages. The quantification of and treatment efficacy for antibiotic removal were determined via solid phase extraction followed by chromatographic separation by liquid chromatography coupled with tandem triple quadrupole mass spectrometry (LC/MS/MS). This analytical system is quite efficient for the detection of all major antibiotic classes, even if they are present at very low concentrations. The efficiency of ozonation was determined by measuring the TOC (Total Organic Carbon) changes after ozonation of the model wastewater and by measuring the concentration of the two antibiotics. In a sequential activated sludge process of ozone-treated model wastewater, almost complete TOC removal and an overwhelming decrease in antibiotic concentrations (up to 99%) were observed. Ozonation resulted in complete removal of AMX and CIP in less than 30 and 120 min, respectively. The results of this work indicate that ozonation could be a suitable pretreatment method to reduce the toxicity of contaminants (AMX and CIP) and improve the biodegradability of hospital wastewater.
Ključne besede: antibiotics, amoxicillin, AMX, ciprofloxacin, CIP, hospital wastewater, hydrogen peroxide, ozone, sludge, water treatment
Objavljeno v DKUM: 06.08.2024; Ogledov: 75; Prenosov: 14
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7. Factors of hospital mortality in men and women with ST-elevation myocardial infarction - an observational, retrospective, single centre studyMartin Marinšek, David Šuran, Andreja Sinkovič, 2023, izvirni znanstveni članek Opis: Purpose: There are well-known gender differences in mortality of patients with ST-elevation myocardial infarction (STEMI). Our purpose was to assess factors of hospital mortality separately for men and women with STEMI, which are less well known.
Patients and Methods: In 2018– 2019, 485 men and 214 women with STEMI underwent treatment with primary percutaneous coronary intervention (PCI). We retrospectively compared baseline characteristics, treatments and hospital complications between men and women, as well as between nonsurviving and surviving men and women with STEMI.
Results: Primary PCI was performed in 94% of men and 91.1% of women with STEMI, respectively. The in-hospital mortality was significantly higher in women than in men (14% vs 8%, p=0.019). Hospital mortality in both genders was associated significantly to older age, heart failure, prior resuscitation, acute kidney injury, to less likely performed and less successful primary PCI and additionally in men to hospital infection and in women to bleeding. In men and women ≥ 65 years, mortality was similar (13.3% vs 17.8%, p = 0.293).
Conclusion: Factors of hospital mortality were similar in men and women with STEMI, except bleeding was more likely observed in nonsurviving women and infection in nonsurviving men.
Ključne besede: ST-elevation myocardial infarction, female sex, male sex, sex differences, hospital mortality, 30-day survival, 6-month survival
Objavljeno v DKUM: 12.07.2024; Ogledov: 124; Prenosov: 22
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8. Impact of dual dispatch system implementation on response times and survival outcomes in out-of-hospital cardiac arrest in rural areasMatej Strnad, Pia Jerot, Vesna Borovnik Lesjak, 2022, izvirni znanstveni članek Opis: Objectives: Dual dispatch early defibrillation in out-of-hospital cardiac arrest (OHCA) victims provided by firefighters in addition to Emergency medical services (EMS) has proven to increase rate of return of spontaneous circulation (ROSC) and thus survival in the metropolitan or suburban areas whereas the data in rural areas are scarce.
Methods: This was a retrospective observational cohort study of EMS resuscitated OHCA victims in regions with dual dispatch of volunteer firefighters as first responders (intervention group). Historical group was based on all OHCAs occurring in these regions before the implementation of first responders (EMS response only). Multivariate logistic regression with following variables: intervention, age, gender, witnessed status, bystander cardiopulmonary resuscitation (CPR), first rhythm and etiology were used to control for confounding factors affecting ROSC.
Results: A total of 312 OHCAs were included in the study (historical group, n = 115 and intervention group, n = 197). Median time to arrival of first help shortened significantly for all patients, patients with ROSC and patients with Cerebral Performance Category 1/2 (CPC 1/2) in intervention vs historical group (8 vs 12 min, p < 0.001; 7.5 vs 11 min, p = 0.002; 7 vs 10 min, p = 0.011; respectively). The proportion of patients with ROSC, 30-day survival and CPC 1/2 at hospital discharge remained unchanged in intervention vs historical group (21% vs 23%, p = 0.808; 7% vs 6%, p = 0.914; 6% vs 3%, p = 0.442; respectively). The logistic regression model of adjustment confirms the absence of improvement in the ROSC rate after the implementation of first responders.
Conclusions: Introduction of a dual dispatch of local first responders in addition to EMS in cases of OHCA significantly shortened response times. However, reduced response times were not associated with better survival outcomes.
Ključne besede: automated external defibrillator, out-of-hospital cardiac arrest, first responder, survival rate, sudden cardiac death, cardiopulmonary resuscitation, firefighters
Objavljeno v DKUM: 12.07.2024; Ogledov: 105; Prenosov: 22
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9. Dynamics of capillary lactate levels in patients with out-of-hospital cardiac arrestVitka Vujanović, Vesna Borovnik Lesjak, Dušan Mekiš, Matej Strnad, 2023, izvirni znanstveni članek Opis: Background and Objectives:
An effective strategy for cardiopulmonary resuscitation should be based on tissue perfusion. Our primary aim was to determine the association between capillary lactate values and initial rhythm as well as the probability of the return of spontaneous circulation in out-of-hospital cardiac arrest patients. Materials and
Methods:
This prospective observational cohort study included all patients with non-traumatic out-of-hospital cardiac arrest, older than 18 years, resuscitated by a prehospital emergency medical team between April 2020 and June 2021. Capillary lactate samples were collected at the time of arrival and every 10 min after the first measurement until the time of the return of spontaneous circulation (ROSC) or, if ROSC was not achieved, at the time of declaring death on the scene.
Results:
In total, 83 patients were enrolled in the study. ROSC was achieved in 28 patients (33.7%), 21 were admitted to hospital (26.3%), and 6 (7.23%) of them were discharged from hospital. At discharge, all patients had Cerebral Performance Category Scale 1 or 2. Initial capillary lactate values were significantly higher in patients with a non-shockable rhythm compared to the group with a shockable rhythm (9.19 ± 4.6 versus 6.43 ± 3.81; p = 0.037). A significant difference also persisted in a second value taken 10 min after the initial value (10.03 ± 5,19 versus 5.18 ± 3.47; p = 0.019). Capillary lactate values were higher in the ROSC group and non-ROSC group at the time of restored circulation (11.10 ± 6.59 and 6.77 ± 4.23, respectively; p = 0.047).
Conclusions:
Capillary lactate values are significantly higher in patients with a non-shockable first rhythm in out-of-hospital cardiac arrest (OHCA). There is also a significantly different rise in capillary lactate levels in patients with ROSC.
Ključne besede: cardiopulmonary resuscitation, out-of-hospital cardiac arrest, lactate, return of spontaneous circulation
Objavljeno v DKUM: 16.04.2024; Ogledov: 156; Prenosov: 24
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10. In-hospital bleeding occurring while treating ST-segment elevation myocardial infarction during the COVID-19 pandemic: STEMI during the COVID-19 pandemicMatej Kvartuh, Domen Lah, Martin Marinšek, David Šuran, Andreja Sinkovič, 2023, izvirni znanstveni članek Ključne besede: COVID-19 pandemic, ST-elevation myocardial infarction, bleeding, mortality, hospital complications
Objavljeno v DKUM: 21.12.2023; Ogledov: 289; Prenosov: 20
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