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Proceedings of the 2021 7th Student Computer Science Research Conference (StuCoSReC)
2021, zbornik

Opis: The 7th Student Computer Science Research Conference is an answer to the fact that modern PhD and already Master level Computer Science programs foster early research activity among the students. The prime goal of the conference is to become a place for students to present their research work and hence further encourage students for an early research. Besides the conference also wants to establish an environment where students from different institutions meet, let know each other, exchange the ideas, and nonetheless make friends and research colleagues. At last but not least, the conference is also meant to be meeting place for students with senior researchers from institutions others than their own.
Ključne besede: student conference, computer and information science, artificial intelligence, data science, data mining
Objavljeno: 13.09.2021; Ogledov: 101; Prenosov: 11
.pdf Celotno besedilo (11,87 MB)
Gradivo ima več datotek! Več...

Role of magnesium ions in the reaction mechanism at the interface between Tm1631 protein and its DNA ligand
Mitja Ogrizek, Janez Konc, Urban Bren, Milan Hodošček, Dušanka Janežič, 2016, izvirni znanstveni članek

Opis: A protein, Tm1631 from the hyperthermophilic organism Thermotoga maritima belongs to a domain of unknown function protein family. It was predicted that Tm1631 binds with the DNA and that the Tm1631–DNA complex is an endonuclease repair system with a DNA repair function (Konc et al. PLoS Comput Biol 9(11): e1003341, 2013). We observed that the severely bent, strained DNA binds to the protein for the entire 90 ns of classical molecular dynamics (MD) performed; we could observe no significant changes in the most distorted region of the DNA, where the cleavage of phosphodiester bond occurs. In this article, we modeled the reaction mechanism at the interface between Tm1631 and its proposed ligand, the DNA molecule, focusing on cleavage of the phosphodiester bond. After addition of two Mg2+ ions to the reaction center and extension of classical MD by 50 ns (totaling 140 ns), the DNA ligand stayed bolted to the protein. Results from density functional theory quantum mechanics/molecular mechanics (QM/MM) calculations suggest that the reaction is analogous to known endonuclease mechanisms: an enzyme reaction mechanism with two Mg2+ ions in the reaction center and a pentacovalent intermediate. The minimum energy pathway profile shows that the phosphodiester bond cleavage step of the reaction is kinetically controlled and not thermodynamically because of a lack of any energy barrier above the accuracy of the energy profile calculation. The role of ions is shown by comparing the results with the reaction mechanisms in the absence of the Mg2+ ions where there is a significantly higher reaction barrier than in the presence of the Mg2+ ions.
Ključne besede: methods of analysis, computer science, magnesium ions, preteins, DNA
Objavljeno: 26.06.2017; Ogledov: 608; Prenosov: 348
.pdf Celotno besedilo (2,91 MB)
Gradivo ima več datotek! Več...

In search of good science teaching with hands-on and minds-on computer-supported activities
Andrej Šorgo, 2011, objavljeni znanstveni prispevek na konferenci

Opis: In maximizing the effect of emerging technologies pre-service teachers should receive assistance in building complex knowledge of how to meaningfully integrate content, pedagogy and technology into the construct of Technological Pedagogical Content Knowledge (PCTK). Teaching by design was found to be a promising strategy in order to support prospective teachers in finding ways to introduce hands-on and mind-on computer-supported activities into their teaching practice.
Ključne besede: education, science, biology teaching, computer-supported learning
Objavljeno: 07.06.2012; Ogledov: 1555; Prenosov: 30
URL Povezava na celotno besedilo

Development of basic competences in science and technology in minorities with language-independent computer simulations
Miro Puhek, Andrej Šorgo, 2011, izvirni znanstveni članek

Opis: With the growth of multimedia computers became more important than ever. Internet became linking media that connects people. But circumstances are far from being perfect. On one hand, we have circumstances similar to those in Eden, where students can use various didactical tools, and on the other, students are still left with the white chalk and black board. The main purpose of this article is to present the problem of accessibility of multimedia to users that have limited knowledge of foreign language (in most cases English). On the Faculty of Natural Sciences and Mathematics we developed interactive computer simulations of biological laboratory exercises. Simulations are equipped with translational support that enables users a translation into a chosen foreign language. The simulations Osmosis and Greenhouse effect are presented in this article and can be used by minorities in Slovenia as well as by anybody else who is not fluent in Slovenian language.
Ključne besede: education, biology, computer science, computerized laboratory
Objavljeno: 07.06.2012; Ogledov: 1242; Prenosov: 17
URL Povezava na celotno besedilo

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