1. Digital transformation reduces costs of the paints and coatings development processTomaž Kern, Eva Krhač Andrašec, Benjamin Urh, Marjan Senegačnik, 2020, izvirni znanstveni članek Opis: An essential characteristic of the new product development process is to develop a new marketable product in the shortest possible time with the lowest reasonable costs. Therefore, the key factor of the process is efficiency. The paints and coatings industry development process contain numerous laboratory tests to determine the appropriateness of new formulation. It is proven that digital transformation can reduce the number of laboratory tests and consequently shorten the throughput time of the development process. This raised the question of whether the faster development process also reduces the process’ cost, or they even increase due to information and communication technology implementation. Therefore, the research’s purpose was to determine whether reducing the number of laboratory tests, based on the implementation of information and communication technology (ICT), affects reducing costs in the paints and coatings development process. The conventional process and the redesigned process of paints and coatings development were used as the basis of the research. The comparative analysis of the costs incurred during the development process was made. The analysis compares the types and amount of incurred costs. The article proves that digital transformation has a significant impact on up to 48% on reducing costs of the paints and coatings development process. Ključne besede: coatings industry, digital transformation, development process, process redesign, technical enabler, implementation cost, rentability threshold Objavljeno v DKUM: 24.01.2025; Ogledov: 0; Prenosov: 3
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2. Nanodelci hitozana kot potencialni protimikrobni premazZdenka Peršin Fratnik, Uroš Maver, Metod Kolar, Olivera Šauperl, Lidija Fras Zemljič, Boštjan Vihar, 2024, izvirni znanstveni članek Opis: Namen študije je bil ugotoviti protimikrobno učinkovitost hitozanskih nanodelcev v primerjavi s hitozansko raztopino in sled temu njihovo učinkovito rabo na medicinskih tekstilnih materialih. Ključne besede: chitosan, nanoparticles, antimicrobial activity, coatings, medical textile materials Objavljeno v DKUM: 07.01.2025; Ogledov: 0; Prenosov: 17
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3. Antithrombogenic polysaccharide coatings to improve hemocompatibility, protein-repellence, and endothelial cell responseMatej Bračič, Bence M. Nagy, Olivija Plohl, Florian Lackner, Tobias Alexander Steindorfer, Roland Fischer, Thomas Heinze, Andrea Olschewski, Karin Stana-Kleinschek, Chandran Nagaraj, Tamilselvan Mohan, 2024, izvirni znanstveni članek Opis: Polyester biomaterials play a crucial in vascular surgery, but suffer from unspecific protein adsorption,
thrombogenicity, and inadequate endothelial cell response, which limit their success. To address these issues, we investigated the functionalization of polyester biomaterials with antithrombogenic polysaccharide coatings. A two-step and water-based method was used to coat cationized polycaprolactone with
different sulfated polysaccharides (SPS), which resulted in long-term stability, tunable morphology,
roughness, film thickness, chemical compositions, zeta potential, and water content. The coatings significantly increased the anticoagulant activity and reduced the thrombogenicity of polycaprolactone, particularly with highly sulfated heparin and cellulose sulfate. Less SPS, such as chondroitin sulfate, fucoidan,
and carrageenan, despite showing reduced anticoagulant activity, also exhibited lower fibrinogen adsorption. The adhesion and viability of human primary endothelial cells cultured on modified polycaprolactone
correlated with the type and sulfate content of the coatings. Ključne besede: polyester biomaterials, vascular surgery, antithrombogenic polysaccharide coatings Objavljeno v DKUM: 10.09.2024; Ogledov: 65; Prenosov: 10
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4. Implementation of the digital sales channel in the coatings industryEva Krhač Andrašec, Marjan Senegačnik, Benjamin Urh, Tomaž Kern, 2021, izvirni znanstveni članek Opis: The development process in the coatings industry can be shortened by digital transformation, and its costs can be reduced using a technical enabler. However, formulators need up-to-date and comprehensive data on existing and potential ingredients to develop the formulation. We were curious about how to supply formulators with data. The idea was that suppliers of ingredients provide data using the “common enabling technology”. We hypothesize that direct data entry compensates suppliers because they can shorten the sales process and increase sales. We used a survey to select key sales channels in the industry. Detailed process models were designed using structured interviews. We analyzed models using structural and operational indicators. Finally, we formed a new digital sales process and verified it. The results show that the digitally formatted sales process can be shortened by up to 32%. Simultaneously, more potential customers can be accessed using the common technology. Existing sales channels would not be closed down. Nevertheless, the digital sales channel is expected to prove its worth over time and gradually increase its share. The suppliers of ingredients can thus avoid a radical process transformation and the immediate integration of additional information technology into the company information system in such an evolutionary way. Ključne besede: digital sales channel, process analyses and improvement, digital transformation, technical enabler, coatings industry, process simulation Objavljeno v DKUM: 06.08.2024; Ogledov: 103; Prenosov: 10
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5. Bioactive functional nanolayers of chitosan-lysine surfactant with single- and mixed-protein-repellent and antibiofilm properties for medical implantsUrban Ajdnik, Lidija Fras Zemljič, Olivija Plohl, Lourdes Pérez, Janja Trček, Matej Bračič, Tamilselvan Mohan, 2021, izvirni znanstveni članek Opis: Medical implant-associated infections resulting from biofilm formation triggered by unspecific protein adsorption arethe prevailing cause of implant failure. However, implant surfaces rendered with multifunctional bioactive nanocoatings offer apromising alternative to prevent the initial attachment of bacteria and effectively interrupt biofilm formation. The need to researchand develop novel and stable bioactive nanocoatings for medical implants and a comprehensive understanding of their properties incontact with the complex biological environment are crucial. In this study, we developed an aqueous stable and crosslinker-freepolyelectrolyte−surfactant complex (PESC) composed of a renewable cationic polysaccharide, chitosan, a lysine-based anionicsurfactant (77KS), and an amphoteric antibiotic, amoxicillin, which is widely used to treat a number of infections caused by bacteria.We successfully introduced the PESC as bioactive functional nanolayers on the“model”and“real”polydimethylsiloxane (PDMS)surfaces under dynamic and ambient conditions. Besides their high stability and improved wettability, these uniformly depositednanolayers (thickness: 44−61 nm) with mixed charges exhibited strong repulsion toward three model blood proteins (serumalbumin,fibrinogen, andγ-globulin) and their competitive interactions in the mixture in real-time, as demonstrated using a quartzcrystal microbalance with dissipation (QCM-D). The functional nanolayers with a maximum negative zeta potential (ζ:−19 to−30mV at pH 7.4), water content (1628−1810 ng cm−2), and hydration (low viscosity and elastic shear modulus) correlated with themass, conformation, and interaction nature of proteins. In vitro antimicrobial activity testing under dynamic conditions showed thatthe charged nanolayers actively inhibited the growth of both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcusaureus) bacteria compared to unmodified PDMS. Given the ease of fabrication of multifunctional and charged biobased coatingswith simultaneous protein-repellent and antimicrobial activities, the limitations of individual approaches could be overcome leadingto a better and advanced design of various medical devices (e.g., catheters, prosthetics, and stents). Ključne besede: silicone implants, protein-repellent, antimicrobial, chitosan, lysine, bioactive coatings, adsorption, QCM-D Objavljeno v DKUM: 15.04.2024; Ogledov: 266; Prenosov: 16
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7. 3D printed poly(lactic acid)-based nanocomposite scaffolds with bioactive coatings for tissue engineering applicationsMaria-Eirini Grigora, Zoi Terzopoulou, Diana Baciu, Theodore Steriotis, Georgia Charalambopoulou, Eleni Gounari, Dimitrios Bikiaris, Dimitrios Tzetzis, 2023, izvirni znanstveni članek Ključne besede: tissue engineering, nanocomposites, 3D printing, bioactive coatings, applications Objavljeno v DKUM: 02.04.2024; Ogledov: 249; Prenosov: 15
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8. Study of the application of recycled gold nanoparticles in coatings for eyewear lensesPeter Majerič, Djuro Koruga, Zorana Njegovan, Žiga Jelen, Tilen Švarc, Andrej Horvat, Rebeka Rudolf, 2023, izvirni znanstveni članek Ključne besede: gold nanoparticles, fullerene C60, lens, coatings, characterisation Objavljeno v DKUM: 28.03.2024; Ogledov: 183; Prenosov: 20
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9. Bioactive coatings with anti-osteoclast therapeutic agents for bone implant : enhanced compliance and prolonged implant lifeDragana Bjelić, Matjaž Finšgar, 2022, pregledni znanstveni članek Opis: The use of therapeutic agents that inhibit bone resorption is crucial to prolong implant life, delay revision surgery, and reduce the burden on the healthcare system. These therapeutic agents include bisphosphonates, various nucleic acids, statins, proteins, and protein complexes. Their use in systemic treatment has several drawbacks, such as side effects and insufficient efficacy in terms of concentration, which can be eliminated by local treatment. This review focuses on the incorporation of osteoclast inhibitors (antiresorptive agents) into bioactive coatings for bone implants. The ability of bioactive coatings as systems for local delivery of antiresorptive agents to achieve optimal loading of the bioactive coating and its release is described in detail. Various parameters such as the suitable concentrations, release times, and the effects of the antiresorptive agents on nearby cells or bone tissue are discussed. However, further research is needed to support the optimization of the implant, as this will enable subsequent personalized design of the coating in terms of the design and selection of the coating material, the choice of an antiresorptive agent and its amount in the coating. In addition, therapeutic agents that have not yet been incorporated into bioactive coatings but appear promising are also mentioned. From this work, it can be concluded that therapeutic agents contribute to the biocompatibility of the bioactive coating by enhancing its beneficial properties. Ključne besede: bioactive coatings, implants, bone resorption, osteolysis, osteoclats inhibitors Objavljeno v DKUM: 17.08.2023; Ogledov: 356; Prenosov: 48
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10. Novel chitosan/diclofenac coatings on medical grade stainless steel for hip replacement applicationsMatjaž Finšgar, Amra Perva, Janja Stergar, Lidija Gradišnik, Uroš Maver, 2016, izvirni znanstveni članek Opis: Corrosion resistance, biocompatibility, improved osteointegration, as well the prevention of inflammation and pain are the most desired characteristics of hip replacement implants. In this study we introduce a novel multi-layered coating on AISI 316LVM stainless steel that shows promise with regard to all mentioned characteristics. The coating is prepared from alternating layers of the biocompatible polysaccharide chitosan and the non-steroid anti-inflammatory drug (NSAID), diclofenac. Electrochemical methods were employed to characterize the corrosion behavior of coated and uncoated samples in physiological solution. It is shown that these coatings improve corrosion resistance. It was also found that these coatings release the incorporated drug in controlled, multi-mechanism manner. Adding additional layers on top of the as-prepared samples, has potential for further tailoring of the release profile and increasing the drug dose. Biocompatibility was proven on human-derived osteoblasts in several experiments. Only viable cells were found on the sample surface after incubation of the samples with the same cell line. This novel coating could prove important for prolongation of the application potential of steel-based hip replacements, which are these days often replaced by more expensive ceramic or other metal alloys. Ključne besede: corrosion, corrosion resistance, chitosan, biocompatibility, biomaterials, biomedical materials, coatings, stainless steel Objavljeno v DKUM: 23.06.2017; Ogledov: 2073; Prenosov: 392
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