Iskanje po katalogu digitalne knjižnice

Opis: Antimicrobial resistance (AMR) is increasing worldwide. This is due to the widespread and often uncontrolled release of antibiotics into surface water, drinking water, and the food chain. The traces of antibiotics (ng/L to μg/L) bioaccumulate, disrupt ecosystems, and accelerate AMR, yet regulatory monitoring remains inadequate. Sensitive analytical methods for the detection and quantification of antibiotics at trace levels in complex matrices are therefore essential. Conventional techniques, i.e., liquid or gas chromatography, mass spectrometry, and capillary electrophoresis, offer high accuracy but are associated with costly instrumentation, lengthy workflows, and extensive sample preparation. Electrochemical sensors based on advanced nanomaterials, particularly magnetic nanoparticles (MNPs), have attracted considerable interest due to their advantages in sensitivity and selectivity, wide linear dynamic ranges, extremely low limits of detection (LOD) and quantification (LOQ), low instrument cost, and rapid response. This review provides a critical overview of recent advances in MNP-based electrochemical platforms for antibiotic detection. The focus is on wet-chemical synthesis routes, modification approaches, and strategies for integrating magnetic nanocomposites into electrodes. Synergistic improvements through hybrid architectures are emphasized, combining MNPs with carbon nanomaterials, biopolymers, metal–organic frameworks, and molecularly imprinted polymers. Trends over the last five years have shown that applications in environmental monitoring, food safety, and drinking water are increasing. We summarize the key performance metrics, outline the current technical bottlenecks, such as long-term stability and large-scale manufacturing, and provide an outlook for the future. Taken together, these developments position MNP-based electrochemical sensors as versatile, highly effective tools for curbing antibiotic pollution and slowing the advancement of AMR.
Ključne besede: electrochemical sensor, antibiotics̀ determination, magnetic nanomaterials, material chemistry, nanocomposites, antimicrobial resistance, food safety, environmental sensing
Objavljeno v DKUM: 04.12.2025; Ogledov: 0; Prenosov: 2
Celotno besedilo (3,13 MB)
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Ključne besede: plastic materials, (bio)degradation, soil, surface chemistry, thermal properties, surface zeta potential
Objavljeno v DKUM: 28.02.2025; Ogledov: 0; Prenosov: 12
Celotno besedilo (10,81 MB)

Ključne besede: medicinal chemistry, filtering chemical libraries, chemical space, HTVS, virtual screening, computer aided drug-design, in silico drug design, bioinformatics, chemoinformatic, compound library
Objavljeno v DKUM: 20.05.2024; Ogledov: 168; Prenosov: 26
Celotno besedilo (1,66 MB)
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Opis: Tissue engineering (TE) is an interdisciplinary field that aims towards replacement, healing or reconstruction of damaged tissue and organs. Incurable diseases are currently treated with organ transplantation, that have the disadvantages of insufficient donors, immune response, and organ rejection after transplantation. TE imitate the functions of extracellular matrix (ECM) to develop biocompatible/biodegradable scaffolds with appropriate features which are utilized to provide mechanical support, cellular infiltration, migration, and tissue formation, and to mimic the biochemical and biophysical cues of cells. Several fabrication methods have been introduced to mimic the 3D structure of ECM and 3D printing is one of the additive manufacturing techniques, widely used in TE because of its feasibility to build complex tissue constructs and control over fabrication and cell distribution. The polysaccharide-peptide conjugate has gained enormous interest in recent years owing to its biocompatibility, degradability, flexibility, and structural matching to natural proteoglycans. In this context, we reported here on investigation of biocompatibility with HUVECs, surface modification of 3D printed PCL scaffolds with an amine group and chemically crosslinked oxidized HA-amino acid/peptide conjugates (OHACs) was used to develop a novel biomaterial for use as a tissue engineered vascular graft. Modified polysaccharides were characterized with respect to their chemical structure, charge, UV and fluorescence properties and cytotoxicity. The successful conjugation was demonstrated by XPS, and a decrease in the free amine peaks on the surface was observed after conjugation. In addition, the water contact angle measurements showed improved wetting, an indication that the conjugation to the PCL-A surface was successful. Finally, the biocompatibility of the novel scaffolds was characterized by the MTS and the live- dead assay. In both assays, proliferation of cells was observed after 7 days and cell spreading on the surface was detected by phalloidin staining of actin filaments. In conclusion, it was possible to prepare surface-active scaffolds by combining the advantages of biocompatibility and mechanical strength of polysaccharides and polyesters, respectively.
Ključne besede: 3D tiskanje, karboksimetilceluloza, hialuronska kislina, polikaprolakton, kemija karbodiimida, kemija Shiffove baze, endotelizacija 3D printing, carboxymethyl cellulose, hyaluronic acid, polycaprolactone, carbodiimide chemistry, shiff-base chemistry, endothelialization
Objavljeno v DKUM: 06.10.2023; Ogledov: 522; Prenosov: 61
Celotno besedilo (7,97 MB)

Opis: Project-based learning (PBL) is a teaching method through which students gain knowledge and skills while working on a project for an extended period of time. They investigate and respond to an authentic, engaging, and complex problem. The popularity of PBL is constantly rising. However, PBL is hard to understand and therefore harder to implement in schools. In the master's thesis we wanted to understand how Slovenian chemistry teachers understand PBL, and how do they implement it in their teaching of chemistry or chemistry related subjects. We created a questionnaire on Google forms and distributed it to chemistry teachers of all Slovenian lower secondary schools and general upper secondary schools. We gathered 130 answers, out of which 95 were teachers who teach in lower secondary schools and 35 who teach in general upper secondary schools. According to the results, teachers barely understand PBL. A majority of teachers are convinced that they use PBL, when the results show that in practice they do not. Project-based learning is often confused for problem-based learning, which is the main confusion for the teachers. Our respondents believe that, because of extensive curriculum and lack of time, it is not possible to fully implement PBL in Slovenian schools.
Ključne besede: project-based learning, teachers, chemistry, understanding
Objavljeno v DKUM: 29.10.2020; Ogledov: 1138; Prenosov: 65
Celotno besedilo (1,28 MB)