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Exocytosis of insulin in vivo maturation of mouse endocrine pancreas
Aldo Rozzo, Tiziana Meneghel-Rozzo, Saška Lipovšek Delakorda, Shi-Bing Yang, Marjan Rupnik, 2009, objavljeni znanstveni prispevek na konferenci

Opis: The aim of this study was to define when an insulin-positive cell becomes functional in vivo and starts to exocytose insulin in a regulated nutrient-dependent manner. Insulin-positive cells appear in embryonic life (midgestation) and complete their maturation, presumably around birth. In order to work with embryonic and newborn endocrine pancreas, we used organotypic slices. The mouse embryonic pancreas slices show high basal insulin release that is not further elevated by high glucose levels. Despite the presence of functional voltage-activated ion channels, the cells are not electrically active in the presence of secretagogues. At birth, the high basalinsulin release drops and, after postnatal day 2, the insulin-positive cells show both adult-like bursting electrical activity and hormone release induced by high glucose levels. These properties allowed us to define them as beta cells. Despite the apparent stability of the transcription factor profile reported in insulin-positive cells during late-embryonic life, functional beta cells appear only 2 days after birth.
Ključne besede: cell biology, insulin release, embrios, newborn, beta-cell maturation, developing pancreas
Objavljeno: 07.06.2012; Ogledov: 957; Prenosov: 19
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