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Kefir grains production - An approach for volume optimization of two stage bioreactor system
Andreja Goršek, Marko Tramšek, 2008, izvirni znanstveni članek

Opis: The main objective of the present study was to design a continuous two-stage bioreactor system for kefir grains production. Based on the experimental data of time-depended kefir grain mass increase and average pH profile during kefir grains batch propagation, parameters of predictive growth and exponential pH models were initially estimated. Afterwards, the non-linear programming (NLP) optimization problem for estimating the optimal volumes of two unequal in series connected continuously stirred tank bioreactors (CSTB) has been developed. The NLP problem is based on criterion of minimal total holding time (MTHT), kefir grain mass balances in CSTB and parameters of the growth and pH models. The results showed that novel kefir grains production plant with two-stage continuous operation, at capacity, qm,KG,pr=3 kgh-1 and conversion, Xo,2=0.980, would primarily require investment in two CSTB with V1=5.93 m3 and V2=5.62 m3, respectively. Technological and economical authorization for a two-stage continuous bioreactor system was mainly confirmed with a more than five times lower total bioreactor volume compared to one-stage plant.
Ključne besede: chemical processing, bioprocesses, milk products, kefir grains production, bioreactor design, modeling, optimization
Objavljeno: 31.05.2012; Ogledov: 1713; Prenosov: 41
URL Povezava na celotno besedilo

Lidija Čuček, 2013, doktorska disertacija

Opis: This doctoral dissertation, which consists of four substantive wholes, presents several syntheses of sustainable bioprocesses using computer-aided process engineering. In the first part the synthesis of different integrated processes of ethanol production from the entire corn plant is presented. The synthesis of different processes is in the second part further extended to the simplified and more comprehensive synthesis of bioproducts in the whole production supply chain network. Synthesis is based on the generic optimisation model of biomass production and supply chain networks. In the third part three methods for sustainable development assessment, suitable for multi-criteria optimisation, are presented: method of sustainability indexes, footprints and combined criteria, such as eco- and total profit. Methods are further upgraded with indirect effects in order to measure the unburdening the environment, associated with the use and replacement of environmentally-harmful products. Methods include the direct, indirect and total impacts on the environment. In the last part the methodology for reducing a large number of criteria within multi-objective optimisation to a small number of representative criteria is presented. This method is presented on the case of environmental footprints.
Ključne besede: Biomass energy generation, Supply chain networks, Synthesis of sustainable bioprocesses, Life Cycle Analysis, Sustainability assessment, Multi-objective optimisation, Dimensionality reduction, Representative Objectives Method
Objavljeno: 06.05.2013; Ogledov: 1402; Prenosov: 177
.pdf Celotno besedilo (4,29 MB)

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