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Artificial biomimetic electrochemical assemblies
Tanja Zidarič, Matjaž Finšgar, Uroš Maver, Tina Maver, 2022, pregledni znanstveni članek

Opis: Rapid, selective, and cost-effective detection and determination of clinically relevant biomolecule analytes for a better understanding of biological and physiological functions are becoming increasingly prominent. In this regard, biosensors represent a powerful tool to meet these requirements. Recent decades have seen biosensors gaining popularity due to their ability to design sensor platforms that are selective to determine target analytes. Naturally generated receptor units have a high affinity for their targets, which provides the selectivity of a device. However, such receptors are subject to instability under harsh environmental conditions and have consequently low durability. By applying principles of supramolecular chemistry, molecularly imprinted polymers (MIPs) can successfully replace natural receptors to circumvent these shortcomings. This review summarizes the recent achievements and analytical applications of electrosynthesized MIPs, in particular, for the detection of protein-based biomarkers. The scope of this review also includes the background behind electrochemical readouts and the origin of the gate effect in MIP-based biosensors.
Ključne besede: MIP-based biosensors, MIP, biosensors, molecularly imprinted polymer, biomolecules, electroanalysis
Objavljeno v DKUM: 15.05.2025; Ogledov: 0; Prenosov: 0
Celotno besedilo (5,11 MB)
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Urinary metabolic biomarker profiling for cancer diagnosis by terahertz spectroscopy : review and perspective
Andreja Abina, Tjaša Korošec, Uroš Puc, Mojca Jazbinšek, Aleksander Zidanšek, 2023, pregledni znanstveni članek

Opis: In the last decade, terahertz (THz) technologies have been introduced to the detection, identification, and quantification of biomolecules in various biological samples. This review focuses on substances that represent important biomarkers in the urine associated with various cancers and their treatments. From a diagnostic point of view, urine liquid biopsy is particularly important because it allows the non-invasive and rapid collection of large volumes of samples. In this review, the THz spectral responses of substances considered metabolic biomarkers in urine and obtained in previous studies are collected. In addition, the findings from the relatively small number of prior studies that have already been carried out on urine samples are summarised. In this context, we also present the different THz methods used for urine analysis. Finally, a brief discussion is given, presenting perspectives for future research in this field, interpreted based on the results of previous studies. This work provides important information on the further application of THz techniques in biomedicine for detecting and monitoring urinary biomarkers for various diseases, including cancer.
Ključne besede: terahertz spectroscopy, urinary biomarkers, metabolic biomarkers, cancer diagnostics, biomolecules, non-invasive detection, biomedical detection
Objavljeno v DKUM: 14.03.2024; Ogledov: 212; Prenosov: 34
Celotno besedilo (12,51 MB)
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