1. Review of potential drug-eluting contact lens technologiesTina Lovrec-Krstič, Kristjan Orthaber, Uroš Maver, Tomislav Šarenac, 2023, pregledni znanstveni članek Opis: The field of ophthalmology is expanding exponentially, both in terms of diagnostic and therapeutic capabilities, as well as the worldwide increasing incidence of eye-related diseases. Due to an ageing population and climate change, the number of ophthalmic patients will continue to increase, overwhelming healthcare systems and likely leading to under-treatment of chronic eye diseases. Since drops are the mainstay of therapy, clinicians have long emphasised the unmet need for ocular drug delivery. Alternative methods, i.e., with better compliance, stability and longevity of drug delivery, would be preferred. Several approaches and materials are being studied and used to overcome these drawbacks. We believe that drug-loaded contact lenses are among the most promising and are a real step toward dropless ocular therapy, potentially leading to a transformation in clinical ophthalmic practice. In this review, we outline the current role of contact lenses in ocular drug delivery, focusing on materials, drug binding and preparation, concluding with a look at future developments.
Ključne besede: contact lens materials, advanced ocular drug delivery, dropless ocular therapy, drug-laden contact lens
Objavljeno v DKUM: 03.12.2024; Ogledov: 0; Prenosov: 1
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3. 3rd International Conference on Aerogels for Biomedical and Environmental Applications : book of abstracts2023 Opis: The 3rd lnternational Conference on Aerogels for Biomedical and Environmental Applications, organized by the Faculty of Chemistry and Chemical Engineering University of Maribor and the AERoGELS COST Action, presented the latest research results and applications of aerogels. This publication compiles the abstracts of the conference and highlights the main results and innovations. The abstracts address the use of aerogels in medical, pharmaceutical, and food applications, including drug delivery systems, scaffolds tor tissue engineering, and bioactive coatings. They also explore aerogels as catalysts, insulators, and environmental solutions and investigate improved catalytic activity and thermal insulation properties. The abstracts emphasize interdisciplinary collaboration and provide ideas tor future research directions. This publication provides valuable insights tor researchers and industry professionals interested in harnessing the remarkable properties of aerogels for biomedical and environmental purposes.
Ključne besede: aerogels, advanced materials, environmental applications, biomedical applications, research and development
Objavljeno v DKUM: 11.08.2023; Ogledov: 507; Prenosov: 78
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4. Computer Modelling of Porous Composite Structures with Advanced Pore MorphologyAljaž Kovačič, 2016, doktorska disertacija Opis: Advanced pore morphology (APM) structures are composite metal foams, which are assembled from a large number of small spherical elements with cellular structure, and are bonded into a composite with polymeric adhesive. The result of such composition is a wide spectrum of achievable mechanical behaviour in APM structures. To explore their full potential, efficient computational models are needed, which allow for simple parameter variation. Unfortunately, the current computer models do not allow for efficient simulations of porous composite structures with advanced pore morphology, as they employ complex discretisation approaches.
A new approach to simulation is presented in this work, based on the discrete particle method (DPM), where every element of APM structure is discretised with a single node. This enables more efficient simulations of APM structures, while still allowing for simple variation of structural parameters. The DPM method was augmented with constitutive models of normal and tangential contact behaviour of APM elements and bonds between them, which were formulated based on an extensive experimental study of APM structure's geometry and mechanical behaviour. Consequently, the models enable simulations of large APM structure's behaviour by modelling the contact behaviour of individual elements.
The implementation of new models was verified on a set of analytically solvable examples, and the accuracy of the models was validated with very good correspondence between computational and experimental results. Moreover, the models were validated on a wide set of examples, also taking into account the various strain rates and the absence of the bonds.
The applicability of new models was demonstrated in a comprehensive parametrical study, where the influential structural parameters and properties were identified for low and high strain rate deformations. The study also demonstrated the possibility of customising the mechanical behaviour with property gradation, and with introduction of regular, as well as geometrically complex APM element assemblies. The possibility of coupled discrete particle method and finite element method simulations was also addressed.
The newly developed models represent a breakthrough in the field of computational investigation of APM structures, and provide for simpler and more efficient investigations of APM structures in the future.
Ključne besede: Metal foams, advanced pore morphology, composite materials, mechanical properties, contact modelling, discrete particle methods, computer simulations
Objavljeno v DKUM: 11.03.2016; Ogledov: 2635; Prenosov: 248
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