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Opis: We recently reported enhanced parasympathetic activation at rest throughout pregnancy associated with regular yoga practice. The present study presents a secondary analysis of data collected within a prospective cohort study of 33 pregnant women practicing yoga once weekly throughout pregnancy and 36 controls not involved in formal pregnancy exercise programs. The objective was to assess the impact of prenatal yoga on the autonomic nervous system stress response. Healthy pregnant women with singleton pregnancies were recruited in the first trimester. There was no significant difference in the maternal body mass index (BMI) between the yoga group and the controls (24.06 ± 3.55 vs. 23.74 ± 3.43 kg/m2, p = 0.693). Women practicing yoga were older (28.6 ± 3.9 vs. 31.3 ± 3.5 years, p = 0.005) and more often nulliparous (26 (79%) vs. 18 (50%), p = 0.001). We studied heart rate variability (HRV) parameters in the time domain (SDNN, standard deviation of regular R-R intervals, and RMSSD, square root of mean squared differences of successive R-R intervals) and frequency domain (ln(LF/HF), natural logarithm of low-frequency to high-frequency power), as well as synchronization indices of heart rate, blood pressure and respiration during and immediately following acute psychological stress of a standardized mental challenge test. Measurements were performed once per trimester before and after yoga or a 30 min moderate-intensity walk. Statistical comparison was performed using three-way analyses of variance (p < 0.05 significant). Time domain HRV parameters during and following mental challenge in the yoga group were significantly higher compared to the controls regardless of the trimester (F = 7.22, p = 0.009 for SDNN and F = 9.57, p = 0.003 for RMSSD, respectively). We observed no significant differences in the yoga group vs. the controls in terms of ln(LF/HF) and synchronization indices. Regular prenatal yoga practice was associated with a significantly reduced sympathetic response to mental challenge and quicker recovery after acute psychological stress. These effects persisted throughout pregnancy with regular practice.
Ključne besede: pregnancy, yoga, heart rate variability, cardio-respiratory adaptation, autonomic nervous system, mental challenge
Objavljeno v DKUM: 28.03.2025; Ogledov: 0; Prenosov: 3
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Opis: Background:To conduct a cross-cultural adaptation and validation of the Core Outcome Measures Index (COMI) in the Slovenian language, for use in patients with low back pain. Methods:The English version of COMI was translated into Slovene following established guidelines. Three hundredfifty-three patients with chronic low back pain were recruited from the Orthopedic clinic department of a tertiary care teaching institution. Data quality, construct validity, responsiveness, and test-retest reliability of the COMI were assessed. Results: The questionnaire was generally well accepted with no missing values. The majority of items exhibited only mild ceiling effects (below 20.0%) and some what more prominent floor effects, which were similar to previousstudies (4.5-78.8%). Correlations with Oswestry Disability Index (ODI) were high (= 0.76 between overall COMI andODI scores), suggesting that the Slovene version of COMI had high construct validity. Additionally, the Slovene version of COMI successfully captured surgical patients' improvement in their low back problem after surgery(overall COMI score change: Z =9.34,p< .001, r =0.53) and showed acceptable test-retest reliability (ICC = 0.86). Conclusions:The Slovene version of COMI showed good psychometric properties, comparable to those of previously tested language versions. It represents a valuable instrument for the use in future domestic and multicenter clinical studies.
Ključne besede: low back pain, validation, core outcome measures index, cross-cultural adaptation, Slovenia
Objavljeno v DKUM: 27.12.2024; Ogledov: 0; Prenosov: 5
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Opis: Background: Beta cells play a key role in the pathophysiology of diabetes since their functional adaptation is able to maintain euglycemia in the face of insulin resistance, and beta cell decompensation or dysfunction is a necessary condition for full-blown type 2 diabetes (T2D). The mechanisms behind compensation and decompensation are incompletely understood, especially for human beta cells, and even less is known about influences of chronic kidney disease (CKD) or immunosupressive therapy after transplantation on these processes and the development of posttransplant diabetes. Summary: During compensation, beta cell sensitivity to glucose becomes left-shifted, i.e., their sensitivity to stimulation increases, and this is accompanied by enhanced signals along the stimulus-secretion coupling cascade from membrane depolarization to intracellular calcium and the most distal insulin secretion dynamics. There is currently no clear evidence regarding changes in intercellular coupling during this stage of disease progression. During decompensation, intracellular stimulus-secretion coupling remains enhanced to some extent at low or basal glucose concentrations but seems to become unable to generate effective signals to stimulate insulin secretion at high or otherwise stimulatory glucose concentrations. Additionally, intercellular coupling becomes disrupted, lowering the number of cells that contribute to secretion. During progression of CKD, beta cells also seem to drift from a compensatory left-shift to failure, and immunosupressants can further impair beta cell function following kidney transplantation. Key Messages: Beta cell stimulus-secretion coupling is enhanced in compensated insulin resistance. With worsening insulin resistance, both intra- and intercellular coupling become disrupted. CKD can progressively disrupt beta cell function, but further studies are needed, especially regarding changes in intercellular coupling.
Ključne besede: human beta cell, functional adaptation, dysfunction, insulin resistance
Objavljeno v DKUM: 15.04.2024; Ogledov: 201; Prenosov: 33
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Opis: As the world economy is growing and globalisation is on the rise, climate change and its effects on the planet Earth are also increasing. But climate changes do not disturb only nature; they also affect businesses and their supply chains. Many companies have recently recognised the positive impacts of green and circular supply chain management practices. Supply chains that deliver products from around the world are increasingly exposed to the impacts of a changing climate and scarce resources. In this research, it was determined how climate change impacts supply chains in the food, automobile, and energy industry sectors. Furthermore, we wanted to find out if and how the management of supply chains is altered to adapt to the business environment which is more and more affected by environmental changes.
Ključne besede: climate change adaptation and mittigation, circular economy, sustainable developement, supply chain management
Objavljeno v DKUM: 16.02.2024; Ogledov: 359; Prenosov: 28
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Opis: The objective of this study is to determine the impacts of expected climate change on slope stability. For this purpose, the case study of a slope instability, that was triggered in 2021 was selected. The stability analysis was performed considering the theory of rainfall infiltration and using Geo-Studio’s SEEP/W module for the surface infiltration model of the slope. A parametric stability analysis of the slope was conducted to determine the importance of climate change on slope stability. Conditions for changes in volumetric water content, water permeability, porewater pressure, and groundwater flow are important. When soil permeability is low, the factor of safety decreases during rainfall events and on the days following, while when permeability is higher, safety increases after rainfall events. The effect of lower cohesion is nearly linear, with the factor of safety decreasing by 0.1 for every 1 kPa less cohesion. The increase in net infiltration of water may be the most critical factor for slope instability. The results of the analysis indicate that timely reduction of water net infiltration through planting and proper surface water runoff from the upper road and slope would be a relatively simple and inexpensive measure compared to the cost of remediating the landslide, considering expected climate change. Therefore, it is advisable to analyze all slopes with respect to the expected climate change, taking into account the potential impacts of climate change.
Ključne besede: climate change adaptation, slope stability, rainfall infiltration, water net infiltration, seepage analyses
Objavljeno v DKUM: 18.08.2023; Ogledov: 478; Prenosov: 982
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