Iskanje po katalogu digitalne knjižnice

Opis: Upright-posture motorcycle crashes against steel safety barriers (SSBs) often result in severe upper-body injuries due to the sharp upper edge of the rail. While solutions for sliding crashes on curves, called a ‘motorcyclist-friendly barrier’, are already implemented in practice, protective measures for upright-posture impacts remain underdeveloped. This study systematically reviews patents and patent applications addressing upper guardrail protection for motorcyclists. We identified and analysed a small number of existing innovations aimed at mitigating the consequences of upright crashes. The selected solutions were evaluated according to their technical design, ease of installation, potential for recycling, environmental compatibility, and expected costs. Our comparative analysis reveals that while some patents or patent applications offer promising features, such as flexible caps, bent plates, or modular attachments, none comprehensively address all safety, environmental, and economic requirements. The findings provide a basis for further development of motorcyclist-friendly SSB designs and suggest specific criteria that should be included in future guidelines and standard updates.
Ključne besede: motorcyclist safety, steel safety barriers, upright-posture crash, motorcycle-friendly barrier, roadside safety, protective barrier design, road infrastructure, injury prevention, patent analysis
Objavljeno v DKUM: 02.07.2025; Ogledov: 0; Prenosov: 1
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Opis: Missing observations can arise due to the effort required to answer many questions in long surveys and the cost required to obtain some responses. Implementing a planned missing design in surveys helps reduce the number of questions each respondent needs to answer, thereby lowering survey fatigue and cutting down on implementation costs. The three-form and the two-method design are two different types of planned missing designs. An important consideration when designing a study with omissions by design is to know how it will affect statistical results. In this work, a simulation study is conducted to analyze how the usual fit measures, root mean square error of approximation (RMSEA), standardized root mean square residual (SRMR), comparative fit index (CFI), and Tucker-Lewis index (TLI) perform in the adjustment of a Structural Equation Model. The results revealed that the CFI, TLI, and SRMR indices exhibit sensitivity to omissions with small samples, low factor loadings and large models. Overall, this study contributes to our understanding of the importance of considering omissions by design in market research.
Ključne besede: omissions by design, Structural Equation Model, survey
Objavljeno v DKUM: 02.06.2025; Ogledov: 0; Prenosov: 0
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Opis: Since December 2019, the new SARS-CoV-2-related COVID-19 disease has caused a global pandemic and shut down the public life worldwide. Several proteins have emerged as potential therapeutic targets for drug development, and we sought out to review the commercially available and marketed SARS-CoV-2-targeted libraries ready for high-throughput virtual screening (HTVS). We evaluated the SARS-CoV-2-targeted, protease-inhibitor-focused and protein–protein-interactioninhibitor-focused libraries to gain a better understanding of how these libraries were designed. The most common were ligand- and structure-based approaches, along with various filtering steps, using molecular descriptors. Often, these methods were combined to obtain the final library. We recognized the abundance of targeted libraries offered and complimented by the inclusion of analytical data; however, serious concerns had to be raised. Namely, vendors lack the information on the library design and the references to the primary literature. Few references to active compounds were also provided when using the ligand-based design and usually only protein classes or a general panel of targets were listed, along with a general reference to the methods, such as molecular docking for the structure-based design. No receptor data, docking protocols or even references to the applied molecular docking software (or other HTVS software), and no pharmacophore or filter design details were given. No detailed functional group or chemical space analyses were reported, and no specific orientation of the libraries toward the design of covalent or noncovalent inhibitors could be observed. All libraries contained pan-assay interference compounds (PAINS), rapid elimination of swill compounds (REOS) and aggregators, as well as focused on the drug-like model, with the majority of compounds possessing their molecular mass around 500 g/mol. These facts do not bode well for the use of the reviewed libraries in drug design and lend themselves to commercial drug companies to focus on and improve.
Ključne besede: targeted libraries, focused libraries, computer-aided drug design, virtual screening, in silico drug design, high-throughput virtual screening
Objavljeno v DKUM: 09.04.2025; Ogledov: 0; Prenosov: 3
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Opis: The publication presents an overview of research activities and research achievements at the Faculty of Mechanical Engineering. The following research areas are presented: Energy, process and environmental engineering, Construction and design, Materials technology, Mechanics, Production engineering, Textile materials and design, and Fundamental and general areas. Individual laboratories and centers of the faculty present their research equipment, service offerings for industry, collaborations with companies and other institutions, the most prominent publications, patents, national and international projects and the most important research achievements.
Ključne besede: energy, construction and design, process and environmental engineering, materials technology, mechanics, production engineering, textile materials and design
Objavljeno v DKUM: 01.04.2025; Ogledov: 0; Prenosov: 2
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Opis: This paper presents a platform developed for automated magnetic flux density measurement. The platform was designed to be used to measure the magnetic flux density of the transmitter/receiver coil of an inductive wireless power transfer system. The magnetic flux density of a transmitter was measured using a small, 3-axis search coil. The search coil was positioned in the 3D space above the transmitter coil using a 3D positioning mechanism and used to measure the magnetic flux density at a specific point. The data was then sent to a computer application to visualize the magnetic flux density. The measured magnetic field could be used in combination with electromagnetic field solvers to design and optimize transmitter coils for inductive wireless power transfer systems.
Ključne besede: magnetic field, magnetic flux density, IPT, transmitter coil design, EM solver
Objavljeno v DKUM: 01.04.2025; Ogledov: 0; Prenosov: 2
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