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Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications
Nika Kučuk, Mateja Primožič, Željko Knez, Maja Leitgeb, 2023, pregledni znanstveni članek

Opis: Biopolymeric nanoparticles are gaining importance as nanocarriers for various biomedical applications, enabling long-term and controlled release at the target site. Since they are promising delivery systems for various therapeutic agents and offer advantageous properties such as biodegradability, biocompatibility, non-toxicity, and stability compared to various toxic metal nanoparticles, we decided to provide an overview on this topic. Therefore, the review focuses on the use of biopolymeric nanoparticles of animal, plant, algal, fungal, and bacterial origin as a sustainable material for potential use as drug delivery systems. A particular focus is on the encapsulation of many different therapeutic agents categorized as bioactive compounds, drugs, antibiotics, and other antimicrobial agents, extracts, and essential oils into protein- and polysaccharide-based nanocarriers. These show promising benefits for human health, especially for successful antimicrobial and anticancer activity. The review article, divided into protein-based and polysaccharide-based biopolymeric nanoparticles and further according to the origin of the biopolymer, enables the reader to select the appropriate biopolymeric nanoparticles more easily for the incorporation of the desired component. The latest research results from the last five years in the field of the successful production of biopolymeric nanoparticles loaded with various therapeutic agents for healthcare applications are included in this review.
Ključne besede: nanoparticles, biopolymers, therapeutic substances, incorporation, biocompatibility, healthcare, biomedical applications
Objavljeno v DKUM: 02.04.2024; Ogledov: 64; Prenosov: 4
.pdf Celotno besedilo (3,50 MB)
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Influence of Al2O3 nanoparticles addition in ZA-27 alloy-based nanocomposites and soft computing prediction
Aleksandar Vencl, Petr Svoboda, Simon Klančnik, Adrian But, Miloš Vorkapić, Marta Harničárová, Blaža Stojanović, 2023, izvirni znanstveni članek

Opis: Three different and very small amounts of alumina (0.2, 0.3 and 0.5 wt. %) in two sizes (approx. 25 and 100 nm) were used to enhance the wear characteristics of ZA-27 alloy-based nanocomposites. Production was realised through mechanical alloying in pre-processing and compocasting processes. Wear tests were under lubricated sliding conditions on a block-on-disc tribometer, at two sliding speeds (0.25 and 1 m/s), two normal loads (40 and 100 N) and a sliding distance of 1000 m. Experimental results were analysed by applying the response surface methodology (RSM) and a suitable mathematical model for the wear rate of tested nanocomposites was developed. Appropriate wear maps were constructed and the wear mechanism is discussed in this paper. The accuracy of the prediction was evaluated with the use of an artificial neural network (ANN). The architecture of the used ANN was 4-5-1 and the obtained overall regression coefficient was 0.98729. The comparison of the predicting methods showed that ANN is more efficient in predicting wear.
Ključne besede: ZA-27 alloy, Al2O3 nanoparticles, nanocomposites, wear, response surface methodology, artificial neural network
Objavljeno v DKUM: 20.03.2024; Ogledov: 89; Prenosov: 4
.pdf Celotno besedilo (14,10 MB)
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Nanomaterials and their recent applications in impedimetric biosensing
Zala Štukovnik, Regina Fuchs-Godec, Urban Bren, 2023, pregledni znanstveni članek

Opis: Impedimetric biosensors measure changes in the electrical impedance due to a biochemical process, typically the binding of a biomolecule to a bioreceptor on the sensor surface. Nanomaterials can be employed to modify the biosensor's surface to increase the surface area available for biorecognition events, thereby improving the sensitivity and detection limits of the biosensor. Various nanomaterials, such as carbon nanotubes, carbon nanofibers, quantum dots, metal nanoparticles, and graphene oxide nanoparticles, have been investigated for impedimetric biosensors. These nanomaterials have yielded promising results in improving sensitivity, selectivity, and overall biosensor performance. Hence, they offer a wide range of possibilities for developing advanced biosensing platforms that can be employed in various fields, including healthcare, environmental monitoring, and food safety. This review focuses on the recent developments in nanoparticle-functionalized electrochemical-impedimetric biosensors.
Ključne besede: impedimetric biosensor, electrochemical impedance spectroscopy, nanomaterials, metal nanoparticles, carbon nanofibers, carbon nanotubes, graphene oxide, quantum dots
Objavljeno v DKUM: 12.02.2024; Ogledov: 5947; Prenosov: 10
.pdf Celotno besedilo (3,14 MB)
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Recovery study of gold nanoparticle markers from lateral flow immunoassays
Tilen Švarc, Peter Majerič, Darja Feizpour, Žiga Jelen, Matej Zadravec, Timi Gomboc, Rebeka Rudolf, 2023, izvirni znanstveni članek

Opis: Lateral flow immunoassays (LFIAs) are a simple diagnostic device used to detect targeted analytes. Wasted and unused rapid antigen lateral flow immunoassays represent mass waste that needs to be broken down and recycled into new material components. The aim of this study was to recover gold nanoparticles that are used as markers in lateral flow immunoassays. For this purpose, a dissolution process with aqua regia was utilised, where gold nanoparticles were released from the lateral flow immunoassay conjugate pads. The obtained solution was then concentrated further with gold chloride salt (HAuCl4) so that it could be used for the synthesis of new gold nanoparticles in the process of ultrasonic spray pyrolysis (USP). Various characterisation methods including scanning electron microscopy, transmission electron microscopy, ultraviolet-visible spectroscopy and optical emission spectrometry with inductively coupled plasma were used during this study. The results of this study showed that the recovery of gold nanoparticles from lateral flow immunoassays is possible, and the newly synthesised gold nanoparticles represent the possibility for incorporation into new products.
Ključne besede: gold nanoparticles, recovery, LFIA, ultrasonic spray pyrolysis, characterisation
Objavljeno v DKUM: 09.02.2024; Ogledov: 147; Prenosov: 14
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Polyvinylpyrrolidone-stabilised gold nanoparticle coatings inhibit blood protein adsorption
Hanuma Reddy Tiyyagura, Matej Bračič, Rebeka Rudolf, 2024, izvirni znanstveni članek

Opis: In this work, the ability of polyvinylpyrrolidone (PVP)-stabilised gold nanoparticle (AuNP) coatings to inhibit blood protein adsorption was evaluated by studying timeresolved solid–liquid interactions of the coatings with the model blood protein bovine serum albumin (BSA). Inhibiting unspecific blood protein adsorption is of crucial importance for blood-contacting implant devices, e.g. vascular grafts, stents, artificial joints, and others, as a preventive strategy for bacterial biofilm formation. A quartz crystal microbalance was used in this work to coat the AuNPs on piezoelectric sensors and to follow time-resolved solid–liquid interactions with the proteins. The AuNP coatings were evaluated for their wettability by contact angle measurements, their surface morphology by lightand atomic force microscopy, and their chemical composition by energy-dispersive X-ray spectroscopy. Results revealed a homogeneous distribution of AuNPs on the sensor surface with a dry mass coverage of 3.37 ± 1.46 µg/cm2 and a contact angle of 25.2 ± 1.1°. Solid–liquid interaction studies by quartz crystal microbalance showed a high repellence of BSA from the PVP-stabilised AuNP coatings and the importance of the PVP in the mechanism of repellence. Furthermore, the conformation of the polymer on the coatings as well as its viscoelastic properties were revealed. Finally, the activated partial thrombin time test and fibrinogen adsorption studies revealed that the AuNPs do not accelerate blood coagulation and can partially inhibit the adhesion of fibrinogen, which is a crucial factor in the common blood coagulation cascade. Such AuNPs have the potential to be used in blood-contact medical applications.
Ključne besede: gold nanoparticles, ultrasonic spray pyrolysis, haemocompatibility, protein adsorption, quartz crystal microbalance
Objavljeno v DKUM: 30.01.2024; Ogledov: 179; Prenosov: 11
.pdf Celotno besedilo (4,61 MB)
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Melting point of dried gold nanoparticles prepared with ultrasonic spray pyrolysis and lyophilisation
Žiga Jelen, Marcin Krajewski, Franc Zupanič, Peter Majerič, Tilen Švarc, Ivan Anžel, Jernej Ekar, Sz-Chian Liou, Jerzy Kubacki, Mateusz Tokarczyk, Rebeka Rudolf, 2023, izvirni znanstveni članek

Opis: A coupled process of ultrasonic spray pyrolysis and lyophilisation was used for the synthesis of dried gold nanoparticles. Two methods were applied for determining their melting temperature: uniaxial microcompression and differential scanning calorimetry (DSC) analysis. Uniaxial microcompression resulted in sintering of the dried gold nanoparticles at room temperature with an activation energy of 26–32.5 J/g, which made it impossible to evaluate their melting point. Using DSC, the melting point of the dried gold nanoparticles was measured to be around 1064.3°C, which is close to pure gold. The reason for the absence of a melting point depression in dried gold nanoparticles was their exothermic sintering between 712 and 908.1°C.
Ključne besede: gold nanoparticles, melting point, ultrasonic spray pyrolysis, characterisation
Objavljeno v DKUM: 08.12.2023; Ogledov: 236; Prenosov: 20
.pdf Celotno besedilo (2,83 MB)
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