Preparation of enantiomers using high pressure technologiesPaul Thorey
, 2010, doktorska disertacija
Opis: The study of two different methods of obtaining chiral alcohols is proposed herein.
The requirement of the relatively new paradigm of green chemistry associated with clean
technologies such as biocatalysis or non-conventional solvents, dense gases, was
focused at. Indeed, the two methods of production of chiral alcohols were:
- the conversion of acetophenone into (R)-1-phenylethanol in dense gases
catalysed by Lactobacillus brevis alcohol dehydrogenase and its
- the resolution of (±)-trans-1,2-cyclohexanediol by cocrystal formation with
tartaric acid followed by supercritical extraction.
In both cases high enantiopurities were achieved (ee>99%).
Ključne besede: High-pressure technologies, enantiomers, green chemistry, R-1-phenylethanol, Lactobacillus brevis, alcohol dehydrogenase, NADP, liquid propane, enzyme deactivation, resolution, trans-1, 2-cyclohexanediol, tartaric acid, cocrystal, supercritical carbon dioxide, extraction, X-ray diffraction, differential scanning calorimetry
Objavljeno v DKUM: 02.02.2011; Ogledov: 2787; Prenosov: 130
Celotno besedilo (6,25 MB)