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2.
Neuropilin (NRPs) related pathological conditions and their modulators
Matic Broz, Anja Kolarič, Marko Jukič, Urban Bren, 2022, pregledni znanstveni članek

Opis: Neuropilin 1 (NRP1) represents one of the two homologous neuropilins (NRP, splice variants of neuropilin 2 are the other) found in all vertebrates. It forms a transmembrane glycoprotein distributed in many human body tissues as a (co)receptor for a variety of different ligands. In addition to its physiological role, it is also associated with various pathological conditions. Recently, NRP1 has been discovered as a coreceptor for the SARS-CoV-2 viral entry, along with ACE2, and has thus become one of the COVID-19 research foci. However, in addition to COVID-19, the current review also summarises its other pathological roles and its involvement in clinical diseases like cancer and neuropathic pain. We also discuss the diversity of native NRP ligands and perform a joint analysis. Last but not least, we review the therapeutic roles of NRP1 and introduce a series of NRP1 modulators, which are typical peptidomimetics or other small molecule antagonists, to provide the medicinal chemistry community with a state-of-the-art overview of neuropilin modulator design and NRP1 druggability assessment.
Ključne besede: neuropilins, computer-aided drug design, in silico drug design, receptor modulator design, peptidomimetics, small-molecule antagonists, cancer, COVID-19, neuropathic pain
Objavljeno v DKUM: 22.08.2023; Ogledov: 311; Prenosov: 26
.pdf Celotno besedilo (11,93 MB)
Gradivo ima več datotek! Več...

3.
GAJA : 3-D CAD methodology for developing a parametric system for the automatic (re)modeling of compound washer dies' cutting-components
David Potočnik, Bojan Dolšak, Miran Ulbin, 2013, izvirni znanstveni članek

Opis: Although the designing of cutting-dies is a complex and experience-based process, it is poorly supported by conventional 3D CAD software. Thus, the majority of design activities, including the (re)modeling of those cutting die-components that are directly responsible for performing shaping operations on a sheet-metal stamping part, traditionally still need to be carried-out repetitively, separately, and manually by the designer. In order to eliminate some of these drawbacks and upgrade the capabilities of conventional 3D CAD software, this paper proposes a new methodology for the development of a parametric system capable of automatically performing a (re)modeling process of compound washer diesć cutting-components. The presented methodology integrates CATIA V5 built-in modules, including Part Design, Assembly Design and Knowledge Advisor, publication mechanism, and compound cutting die-design knowledge. The system developed by this methodology represents an 'intelligent' assembly template composed of two modules 'GAJA1' and 'GAJA2', respectively. 'GAJA1' is responsible for the direct input of the die-design problem regarding the shape, dimensions and material of the stamping part, its extraction in the form of geometric features, and the transferring of relevant design parameters and features to the module 'GAJA2'. 'GAJA2' interprets the current values for the input parameters and automatically performs the modeling process of cutting die-components, using die-design knowledge and the company's internal design and manufacturing standards. Experimental results show that the use of this system significantly shortens the modeling-time for cutting the die-components, improves the modeling-quality, and enables the training of inexperienced designers.
Ključne besede: parametrično modeliranje, rezalna orodja, računalniško podprti sistemi, inteligentno računalniško podprto konstruiranje, parametric modeling, cutting dies, computer-aided systems, knowledge-based design
Objavljeno v DKUM: 10.07.2015; Ogledov: 3077; Prenosov: 49
URL Povezava na celotno besedilo

4.
Uvajanje računalniško podprte proizvodnje
Uroš Trupej, 2013, diplomsko delo

Opis: V svoji diplomski nalogi sem se osredotočil na uvajanje računalniško podprte proizvodnje in kakšne prednosti prinaša. Računalniško podprta proizvodnja združuje moderno računalniško tehnologijo z naprednimi obdelovalnimi stroji in povezavo z informacijskim sistemom, kjer je človek še vedno vodilo napredka. Na teoretičnem primeru sem prikazal kakšne spremembe mora neko podjetje opravit in kakšne pogoje mora zadostiti, da lahko uvede računalniško podprto proizvodnjo.
Ključne besede: RIP - Računalniško integrirana proizvodnja, CIM - Computer integrated manufacturing, CAD - Computer Aided Design.CAM - Computer Aided Manufacturing, CAE - Computer Aided Engeneering, CAQ - Computer Aided Quality Assurance, CAPP - Computer Aideded Process Planning, CABS - Computer Aideded Business Sysytem, CAST - Computer Aideded Storagee and Transport, CNC - Computer Numerical Control, POS - Prilagodljivi obdelovalni stroji
Objavljeno v DKUM: 16.10.2013; Ogledov: 2089; Prenosov: 216
.pdf Celotno besedilo (2,14 MB)

5.
An intelligent system for structural analysis-based design improvements
Marina Novak, Bojan Dolšak, 2008, izvirni znanstveni članek

Opis: The goal of the research work presented in this paper was to collect, organize, and write the knowledge and experience about structural analysis-based design improvements into a knowledge base for a consultative advisory intelligent decision support system. The prototype of the system presented proposes possible design changes that should be taken into consideration to improve the design candidate according to the results of a prior stress-strain or thermal analysis. The system can be applied either in the design of new products or as an educational tool.
Ključne besede: computer-aided design, structural optimisation, knowledge based systems, decision support
Objavljeno v DKUM: 31.05.2012; Ogledov: 4678; Prenosov: 45
URL Povezava na celotno besedilo

6.
Dealing with redundancy and inconsistency in constructive geometric constraint solving
David Podgorelec, Borut Žalik, Vid Domiter, 2008, izvirni znanstveni članek

Opis: General constructive geometric constraint solvers are pre-processed by a degree-of-freedom analysis, which enables efficient graph decomposition and recombination. However, all these methods are based on the assumption that structural rigidity automatically assures solvability. In this paper, we show that this assumption fails in numerous, even the most basic, configurations. We introduce several simple but efficient rules aimed to additionally analyse solvability in such cases. Another novelty addresses conditional constraints between three or more geometric parts, rules for their simplification and a redundancy check. All these functionalities are built into our original 2D geometric constraint solver, based on concepts of rigid clusters and constrained-angle (CA) sets.
Ključne besede: geometric constraint solving, computer-aided design, constructive approach, redundant constraints
Objavljeno v DKUM: 31.05.2012; Ogledov: 1655; Prenosov: 107
URL Povezava na celotno besedilo

7.
RAČUNALNIŠKO PROGRAMIRANJE IN MODELIRANJE DELOVNEGA STROJA
Klemen Gajšek, 2010, diplomsko delo/naloga

Opis: Za diplomsko nalogo sem si izbral temo na področju računalniškega modeliranja in programiranja. Kot praktični primer sem uporabil delovni stroj-cepilec polen, ki služi za cepljenje polen in uporabniku omogoča lažje delo z manj fizičnega napora. V nalogi sem se opredelil predvsem na konstruiranje samega stroja in na posamezne komponente, kako jih izdelati ter preračune, ki jih zajema takšen delovni stroj. V diplomski nalogi bom natančneje prikazal in opisal, s katerimi računalniškimi programi sem si pomagal pri modeliranju celotnega stroja in NC programiranju določene komponente stroja. Naredil sem tudi simulacijo delovanja stroja ter simulacijo poti orodja.
Ključne besede: Computer Aided Design, Constuctive Solid Geometry (CSG), volumetrično modeliranje, NC (numerical control), programiranje numerično krmiljenih strojev.
Objavljeno v DKUM: 11.10.2010; Ogledov: 2307; Prenosov: 359
.pdf Celotno besedilo (2,96 MB)

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