1. Dojemanje oskrbe, osredotočene na pacienta, v treh klinikah za zdravljenje neplodnosti : vpliv zdravljenja v domačem okolju ali tujini in povračila stroškovVeljko Vlaisavljević, Borut Kovačič, 2024, izvirni znanstveni članek Opis: Namen te študije je bil oceniti izkušnje bolnikov z oskrbo, osredotočeno na bolnika (PCC), na treh klinikah za zdravljenje neplodnosti glede na kritje stroškov zdravljenja in kraj, kjer so bili zdravljeni.
Ključne besede: assisted reproductive therapy, cross-border patients, patient treatment experience, patient centeredness, quality of care
Objavljeno v DKUM: 07.01.2025; Ogledov: 0; Prenosov: 22
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2. Health related QoL in celiac disease patients in SloveniaEva Turk, Dušanka Mičetić-Turk, Maja Šikić Pogačar, Alojz Tapajner, Veljko Vlaisavljević, Valentina Prevolnik Rupel, 2020, izvirni znanstveni članek Opis: Background: Measurements of health-related quality of life (HRQoL) among celiac disease patients using a validated questionnaire have been lacking in Slovenia. This study aims to measure HRQoL in celiac disease (CD) patients using EQ-5D internationally validated questionnaire and comparing it to the HRQoL of the general population.
Methods: In this cross sectional analysis all of the approximately 2000 members of the Slovenian Celiac Society were invited to take part. We used a 3 step approach for recruitment and data collection. HRQoL was evaluated through the EuroQoL EQ-5D-5L instrument (Slovenian version) and analysed using the ordinal logistic regression.
Results: Out of 321 patients who gave their consent, 247 celiac patients were included in the study (77%). 68% of the participants were female and 53% of them lived in an urban setting. Most patients originated from North-East Slovenia, whereas approximately 30% of patients came from other Slovenian regions. The EQ-5D respondents’ self-reported health status at the time of the study show that most patients have slight or no problems when living with CD. The duration of the gluten-free diet, academic education and rare (< 1 × year) doctor visits affect EQ-5D in a positive way. On the other hand, higher age and chronic rheumatic disease were negatively associated with EQ-5D also when compared to the general population.
Conclusion: This is the first Slovenian study to measure the HRQoL of Slovenian CD patients, using an internationally validated questionnaire. The results of our study show that HRQoL is slightly impaired among Slovenian patients with CD. Clinical characteristics are better determinants of their HRQoL than socio-demographic factors. Greater awareness of the impact of CD on patients’ HRQoL would improve the holistic management of CD patients.
Ključne besede: health, quality of life, HRQoL, celiac disease, EQ‑5D, valuation, measurement, Slovenia
Objavljeno v DKUM: 06.01.2025; Ogledov: 0; Prenosov: 7
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3. MTHFR C677T and A1298C genotypes and haplotypes in Slovenian couples with unexplained infertility problems and in embryonic tissues from spontaneous abortionsŠpela Stangler Herodež, Boris Zagradišnik, Alenka Erjavec Škerget, Andreja Zagorac, Iztok Takač, Veljko Vlaisavljević, Lidija Lokar, Nadja Kokalj-Vokač, 2013, izvirni znanstveni članek Opis: The objective of this study was to analyze the methylenetetrahydrofolate reductases (MTHFRs) C677T and A1298C genotype distributions in couples with unexplained fertility problems (UFP) and healthy controls, and to analyze the genotype and haplotype distribution in spontaneously aborted embryonic tissues (SAET) using allele specific polymerase chain reaction (PCR) in 200 probands with UFP, 353 samples of SAET and 222 healthy controls. The analysis revealed a significant overall representation of the 677T allele in male probands from couples with UFP (p = 0.036). The combined genotype distribution for both MTHFR polymorphisms was also significantly altered (χ2 21.73, p <0.001) although female probands made no contribution (c2 1.33, p = 0.72). The overall representation of the 677T allele was more pronounced in SAET (0.5 vs. 0.351 in controls, p <0.001) regardless of the karyotype status (aneuploidy vs. normal karyotype). In addition, the frequencies of the CA and CC haplotypes were significantly lower than in the control group (p = 0.021 and p = 0.001, respectively), whereas the frequency of the TC haplotype was significantly higher than in controls (p <0.0001). The presented findings indicate that only male probands contribute to the association of MTHFR mutations with fertility problems in grown adults and demonstrate a high prevalence of mutated MTHFR genotypes in SAET.
Ključne besede: methylenetetrahydrofolate reductase (MTHFR), genotype, haplotype, infertility, miscarriage
Objavljeno v DKUM: 30.03.2017; Ogledov: 1469; Prenosov: 364
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4. GinekologijaDarja Arko, Elko Borko, Radovan Breznik, Igor But, Raja Gošnak Dahmane, Zlatka Rakovec-Felser, Vida Gavrić-Lovrec, Borut Gorišek, Borut Kovačič, Tatjana Kodrič, Božo Kralj, Boštjan Lovšin, Gregor Pivec, Božena Primožič, Milan Reljič, Iztok Takač, Veljko Vlaisavljević, Ivan Žebeljan, Branka Žegura Andrić, 2008, univerzitetni, visokošolski ali višješolski učbenik z recenzijo Opis: Ginekologija
Ključne besede: načrtovanje družine, ginekološka onkologija, neplodnost, reproduktivno zdravje, ženska spolovila, anatomija, ginekološki pregled, menopavza, nosečnost, splav, dojka, urinska inkontinenca, kirurgija
Objavljeno v DKUM: 30.12.2015; Ogledov: 3699; Prenosov: 541
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5. Simultaneous determination of phthalates, their metabolites, alkylphenols and bisphenol a using GC-MS in urine of men with fertility problemsRoman Kranvogl, Jure Knez, Alen Miuc, Ernest Vončina, Darinka Brodnjak-Vončina, Veljko Vlaisavljević, 2014, izvirni znanstveni članek Opis: A GC-MS method was successfully applied to measure simultaneously the concentrations of endocrine disrupting compounds (5 dialkyl phthalates, 9 phthalate monoesters, 3 alkylphenols and bisphenol A) in 136 male urine samples. In the present study the method was validated and concentrations of EDCs were determined. The results were compared with results from other studies. Correlations between endocrine disrupting compounds and also correlations of endocrine disrupting compounds with two semen quality parameters are presented and evaluated. Significant positive correlations were found between almost all the endocrine disrupting compounds. The parameter sum of DEHP (SUM DEHP) was positively correlated to all the endocrine disrupting compounds but negatively to two semen quality parameters. Negative correlations between the endocrine disrupting compounds and the semen quality parameters could indicate that endocrine disrupting compounds could cause reproductive problems by decreasing the semen count and quality. This research will have helped to evaluate human exposure to endocrine disrupting compounds.
Ključne besede: endocrine disrupting compounds, fertility, fertility, phthalates, bisphenol A, alkylphenols, human urine
Objavljeno v DKUM: 21.12.2015; Ogledov: 1937; Prenosov: 175
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6. Usefulness of follicular fluid estradiol and progesterone concentration measurement in predicting outcome of IVF/ICSI natural cyclesVida Gavrić-Lovrec, Veljko Vlaisavljević, Borut Kovačič, Maksimiljan Gorenjak, Milan Reljič, 2012, izvirni znanstveni članek Opis: Purpose: The aim of the study was to establish whether follicular fluid (FF) estradiol (E2) and progesterone (P) measurement could be used to predict the outcome of unstimulated IVF/ICSI cycles. Methods: 91 women underwent 150 unstimulated IVF/ICSI cycles (78 IVF and 72 ICSI). Follicular fluid samples were collected at the time of oocyte recovery. Using the ttest, FF E2 and FF P levels and their ratios (FF P/FF E2) were compared between cycles with successful (with oocyte) and unsuccessful (without oocyte) oocyte recovery, between cycles with and without fertilization and between nonconception and conception cycles. Results: The oocyte recovery rate was 86.7% (123/150), the fertilization rate 68.3% (84/123) and the pregnancy rate per oocyte recovery 14.0% (21/150). The average FF E2 level was 3530 +/- 1339 nmol/L, average FF P 20649 +/- 9489 nmol/Land average FF P/FF E2 ratio 7.18 +/- 6.42. There were no statistically significant differences in FF E2, FF P levels and their ratio between cycles with unsuccessful and successful oocyte recovery, between cycles without and with fertilization, and between nonconception and conception cycles. Conclusion: From the FF E2 and P levels and their ratio, it is not possible to make inferences to the likelihood of oocyte recovery, fertilization and conception in unstimulated IVF/ICSI cycles.
Ključne besede: folikularna tekočina, naravni ciklus, estradiol, progesteron, IVF/ICSI izhod
Objavljeno v DKUM: 10.07.2015; Ogledov: 1476; Prenosov: 77
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7. Reproduktivno zdravje študentkLidija Trop, 2010, diplomsko delo Opis: V svetu in tudi v Sloveniji je prisotnih vedno več težav oziroma motenj v reproduktivnem obdobju ženske populacije. Skrb za zdravje, kamor spada tudi reproduktivno zdravje, sega že v zgodnje otroštvo. Kako skrbeti za reproduktivno zdravje, kakšni so preventivni postopki, ki jih vsaka ženska mora poznati in jih upoštevati, da bo zdrava v svojem fertilnem obdobju, smo raziskali in opisali v diplomski nalogi.
V teoretičnem delu diplomskega dela smo predstavili definicijo reproduktivnega zdravja, dispanzersko dejavnost, diagnostične metode v ginekologiji in vlogo medicinske sestre pri zdravstveni vzgoji in varovanju reproduktivnega zdravja. V drugem, raziskovalnem delu diplomskega dela, je predstavljena raziskava, ki je bila opravljena na Fakulteti za zdravstvene vede v Mariboru in na Pedagoški fakulteti v Mariboru. Večina anketiranih študentk je v treh letih bilo na ginekološkem pregledu, prav tako je večini v tem časovnem obdobju bil odvzet bris po PAP-u. Ena tretjina študentk pozna pravilen način samopregleda dojk, a večina si dojke samopregleduje le občasno. Rezultati raziskave so pokazali, da dve tretjini anketiranih študentk živi zdravo, je pa med študentkami prisotnih še vedno preveč škodljivih razvad, ki znatno slabšajo reproduktivno zdravje.
Ključne besede: reproduktivno zdravje, dejavniki tveganja, zdravstvena vzgoja, ginekološki pregled, medicinska sestra.
Objavljeno v DKUM: 09.08.2010; Ogledov: 3431; Prenosov: 467
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