1. Vpliv probiotikov na kakovost življenja pri bolnikih po operaciji možganovDoroteja Pukšič, 2025, diplomsko delo Opis: Uvod: Komunikacijske poti med možgani in mikrobioto omogočajo, da lahko z
dodajanjem probiotikov vplivamo na črevesno mikrobioto in posledično na kognitivne sposobnosti. Namen zaključnega dela je bil raziskati vpliv probiotikov na kakovost življenja pri bolnikih po operaciji možganov.
Metode: Zaključno delo je temeljilo na pregledu literature z uporabo opisne metode dela. Literaturo smo identificirali iz mednarodnih podatkovnih baz PubMed, ScienceDirect, MEDLINE (EBSCOhost) ter Wiley Online Library. Proces iskanja literature je temeljil na vnaprej opredeljenih vključitvenih in izključitvenih kriterijih ter je prikazan z diagramom poteka v skladu s smernicami PRISMA. Kakovost vključenih raziskav smo ocenili na osnovi
hierarhije dokazov. Uporabili smo tematsko analizo in sintezo podatkov.
Rezultati: V končno analizo smo vključili 6 ustreznih člankov. Raziskave kažejo, da probiotiki prinašajo le določene koristi za kakovost življenja pri bolnikih po operaciji možganov, kot so krajši čas hospitalizacije, zmanjšanje markerjev vnetja, zmanjšanje tveganja za okužbe, nižja umrljivost ter hitrejše okrevanje črevesne funkcije po operaciji možganov.
Razprava in zaključek: Kljub številnim blagodejnim učinkom probiotikov na zdravje naš pregled literature kaže na omejen vpliv probiotikov na kakovost življenja bolnikov po operaciji možganov. Za zanesljivejše zaključke pa so potrebne nadaljnje klinične raziskave z večjim številom udeležencev in standardiziranimi metodami ocenjevanja kakovosti življenja.
Ključne besede: koristne črevesne bakterije, kakovost življenja, nevrološki bolniki, operacija možganov
Objavljeno v DKUM: 24.10.2025; Ogledov: 0; Prenosov: 10
 Celotno besedilo (1,13 MB) |
2. Overview of the efficacy of using probiotics for neurosurgical and potential neurosurgical patientsSabina Fijan, Tomaž Šmigoc, 2024, pregledni znanstveni članek Opis: This review delves into the emerging field of the gut microbiota-brain axis, emphasizing its bidirectional communication and implications for neurological health, particularly in trauma and neurosurgery. While disruptions in this axis can lead to dysbiosis and hinder neurological recovery, recent studies have highlighted the therapeutic potential of interventions like probiotics in targeting this axis. This review aims to focus on the efficacy of probiotic supplementation to support the gut microbiota-brain axis in trauma, neurosurgery, or pain based on the current clinical trials to assess the complex interplays among probiotics, the gut microbiota, and the central nervous system (CNS). This comprehensive literature review identified 10 relevant publications on probiotic interventions for various neurosurgical conditions across multiple countries. These studies demonstrated diverse outcomes, with significant improvements observed in gastrointestinal mobility, inflammatory responses, and infection rates, particularly in post-traumatic brain injury and spinal surgery. Probiotics also showed promise in mitigating antibiotic-associated diarrhea and modulating inflammatory cytokines. Despite the promising findings, the complex interplays among probiotics, the gut microbiota, and the central nervous system (CNS) call for cautious interpretation. Conflicting outcomes emphasize the need for better-designed trials to understand strain-specific and disease-specific effects accurately. In conclusion, probiotics offer a promising adjuvant therapy for neurosurgical patients, traumatic brain injuries, and post-spinal surgery. However, further well-designed randomized controlled trials are essential to elucidate the intricate relationship between microbiome-modulating interventions and the CNS via the gut microbiota-brain axis.
Ključne besede: neurologic injury, neurosurgery, probiotics, synbiotics, microbiota, brain injury
Objavljeno v DKUM: 21.11.2024; Ogledov: 0; Prenosov: 11
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3. Učinki probiotikov pri bolečinah v križuNika Želimorski, 2024, diplomsko delo Opis: Probiotiki so živi mikroorganizmi, ki imajo pozitiven vpliv na zdravje gostitelja, kadar jih vnesemo v zadostni količini. Njihova uporaba prispeva k izboljšanju zdravja ljudi, vključno z vzdrževanjem imunskega sistema. Probiotični izdelki so priljubljena oblika namensko uporabljenih živil, ki koristijo zdravju. Temeljijo na mikroorganizmih, ki se pogosto naravno pojavljajo v črevesni mikrobioti ljudi in vzpostavljajo simbiotski odnos s svojim gostiteljem. Kljub številnim pozitivnim učinkom probiotikov na zdravje naš pregled literature ne prinaša pomembnega vpliva probiotikov na zmanjšanje bolečin v križu, kar kaže na potrebo po nadaljnjih raziskavah, ki bodo razjasnile vlogo specifičnih probiotičnih sevov, doziranja, trajanja terapije in drugih dejavnikov pri lajšanju bolečin v križu.
Ključne besede: probiotiki, bolečine v križu, preprečevanje bolečin, pacienti.
Objavljeno v DKUM: 23.10.2024; Ogledov: 0; Prenosov: 165
Celotno besedilo (802,94 KB) |
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5. Percutaneous trigeminal ganglion balloon compression rhizotomy: experience in 27 patientsTadej Strojnik, Tomaž Šmigoc, 2012, izvirni znanstveni članek Opis: Purpose. Percutaneous ganglion balloon compression (PBC) is a minimally invasive procedure for treatment of trigeminal neuralgia. Materials and Methods. Twenty-seven (19 female and 8 male) patients, who presented with classical symptoms of trigeminal neuralgia, were included. Age ranged from34 to 91 years (median 62 years), 33 procedures were performed. Duration of the symptoms ranged from 1 year to 30 years (median 5 years). Results. After the procedure, pain relief was reported in 25 (93%) patients. In two patients, the pain remained the same. The pain free period ranged from 2 to 74 months (median 15 months). A mean duration of analgesia was longer in patients with ideal pear shape of balloon at the time of the procedure compared to nonideal shape (P = 0.01). No major complications occurred in our group of patients. Conclusions. Percutaneous trigeminal ganglion balloon compression is a safe, simple, and effective method for temporary pain relief in a selective group of trigeminal neuralgia patients.
Ključne besede: balloon compression
Objavljeno v DKUM: 15.06.2017; Ogledov: 1150; Prenosov: 513
Celotno besedilo (2,62 MB)
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