1. Psychometric testing of the Slovene version of the Perceived Inventory of Technological Competency as Caring in NursingCvetka Krel, Dominika Vrbnjak, Gregor Štiglic, Sebastjan Bevc, 2024, izvirni znanstveni članek Opis: The Perceived Inventory of Technological Competency as Caring in Nursing (PITCCN) questionnaire has been designed to measure technological competency as caring in nursing practice. It incorporates the use of technology with the fundamental principles of caring that are central to nursing. As there were no psychometrically sound instruments to quantify the concept of technological competency as caring in the Slovene language, we adapted the English version of the questionnaire to the local environment. The goal was to assess the level of psychometric properties of the PITCCN investigated in Slovene hospitals. Methods: Content validity was conducted with eight experts and quantified by the content validity index (CVI) and the modified Cohen’s kappa index. Face validity was assessed through discussions with participants from the target culture in the pilot study. To assess construct validity and internal consistency, a cross-sectional research methodology was used on a convenience sample of 121 nursing personnel from four hospitals. Principal component analysis (PCA) was used to examine construct validity, while Cronbach’s alpha and adjusted item-total correlations were used to measure internal consistency. Results: The content and face validity of PITCCN were adequate. The scale validity index (S-CVI) was 0.97. Cronbach’s α was 0.92, and subscale reliabilities ranged from 0.810 to 0.925. PCA showed four components, which explained more than 73.49% of the variance. Conclusions: The Slovenian version of PITCCN (PITCCN_SI) has good psychometric properties.
Ključne besede: technology, caring, reliability, validity, psychometric properties
Objavljeno v DKUM: 28.03.2025; Ogledov: 0; Prenosov: 3
 Celotno besedilo (265,87 KB)
Gradivo ima več datotek! Več... |
2. The role of vascular lesions in diabetes across a spectrum of clinical kidney diseaseRosa Rodriguez-Rodriguez, Radovan Hojs, Francesco Trevisani, Enrique Morales, Gema Fernández, Sebastjan Bevc, Clara Maria Cases Corona, Josep Maria Cruzado, María Quaro, Maruja Navarro Díaz, Mads Hornum, Beatriz Fernandez-Fernandez, Arianna Bettiga, Federico Di Marco, Marina López Martínez, Francisco J. Moreso, Clara García Garro, Khaled Khazim, Fedaa Ghanem, Manuel Praga, Meritxell Ibernón, Ivo Laranjinha, Luís Mendonça, Miguel Bigotte Vieira, Bo Feldt-Rasmussen, Patricia Fox Concepción, Natalia Negrín Mena, Alberto Ortiz, Esteban L. Porrini, 2021, izvirni znanstveni članek Opis: Introduction: The clinical-histologic correlation in diabetic nephropathy is not completely known.
Methods: We analyzed nephrectomy specimens from 90 patients with diabetes and diverse degrees of proteinuria and glomerular filtration rate (GFR).
Results: Thirty-six (40%) subjects had normoalbuminuria, 33 (37%) microalbuminuria, and 21 (23%) non-nephrotic proteinuria. Mean estimated GFR (eGFR) was 65±23 (40% <60 ml/min per 1.73 m2). About 170 glomeruli per patient were analyzed, and all samples included vascular tissue. Six subjects (7%) were classified in diabetic nephropathy class I, 61 (68%) in class II-a, 13 (14%) in class II-b, 9 (10%) class III, and 1 (1%) in class IV. Eighty percent to 90% of those with normoalbuminuria or microalbuminuria were classified in class II-a or II-b and <10% in class III; 52% of those with proteinuria were in class II-a, 15% in class II-b, and 19% in class III. Nodular sclerosis (57%) and mesangial expansion (15%) were more frequent in cases with proteinuria than in normoalbuminuria (28% and 8%; P = 0.028 and 0.017). About 20% to 30% of all cases, regardless the level of albuminuria or proteinuria or the histologic class had tubular atrophy, interstitial fibrosis, or inflammation in >10% to 20% of the sample. Moderate hyalinosis and arteriolar sclerosis were observed in 80% to 100% of cases with normoalbuminuria, microalbuminuria, proteinuria, as well as in class I, II, or III.
Conclusions: Weak correspondence between analytical parameters and kidney histology was found. Thus, disease may progress undetected from the early clinical stages of the disease. Finally, vascular damage was a very common finding, which highlights the role of ischemic intrarenal disease in diabetes.
Ključne besede: albuminuria, chronic kidney disease, diabetes, diabetic nephropathy, histology, normoalbuminuria
Objavljeno v DKUM: 06.12.2024; Ogledov: 0; Prenosov: 5
Celotno besedilo (1,56 MB)
Gradivo ima več datotek! Več... |
3. |
4. Assessment of kidney function : clinical indications for measured GFRNatalie Ebert, Sebastjan Bevc, Arend Bökenkamp, Francois Gaillard, Mads Hornum, Kitty Jager, Christophe Mariat, Bjørn Odvar Eriksen, Runolfur Palsson, Andrew D. Rule, 2021, pregledni znanstveni članek Opis: In the vast majority of cases, glomerular filtration rate (GFR) is estimated using serum creatinine, which is highly influenced by age, sex, muscle mass, body composition, severe chronic illness and many other factors. This often leads to misclassification of patients or potentially puts patients at risk for inappropriate clinical decisions. Possible solutions are the use of cystatin C as an alternative endogenous marker or performing direct measurement of GFR using an exogenous marker such as iohexol. The purpose of this review is to highlight clinical scenarios and conditions such as extreme body composition, Black race, disagreement between creatinine- and cystatin C–based estimated GFR (eGFR), drug dosing, liver cirrhosis, advanced chronic kidney disease and the transition to kidney replacement therapy, non-kidney solid organ transplant recipients and living kidney donors where creatinine-based GFR estimation may be invalid. In contrast to the majority of literature on measured GFR (mGFR), this review does not include aspects of mGFR for research or public health settings but aims to reach practicing clinicians and raise their understanding of the substantial limitations of creatinine. While including cystatin C as a renal biomarker in GFR estimating equations has been shown to increase the accuracy of the GFR estimate, there are also limitations to eGFR based on cystatin C alone or the combination of creatinine and cystatin C in the clinical scenarios described above that can be overcome by measuring GFR with an exogenous marker. We acknowledge that mGFR is not readily available in many centres but hope that this review will highlight and promote the expansion of kidney function diagnostics using standardized mGFR procedures as an important milestone towards more accurate and personalized medicine.
Ključne besede: biomarker, chronic kidney disease, clinical indications, creatinine, cystatin C, kidney function, measured glomerular filtration rate
Objavljeno v DKUM: 12.08.2024; Ogledov: 52; Prenosov: 11
Celotno besedilo (607,93 KB)
Gradivo ima več datotek! Več... |
5. |
6. Single peritoneal dialysis centre observations of treatment adequacy, anemia treatment, inflammation, mineral bone disease, and peritonitis rate - in patients undergoing continuous ambulatory peritoneal dialysis versus automated peritoneal dialysisMaša Knehtl, Martin Hren, Nina Vodošek Hojs, Sebastjan Bevc, Radovan Hojs, Robert Ekart, 2017, izvirni znanstveni članek Ključne besede: peritonealna dializa, peritonitis, anemija, eritropoetin, mineralna kostna bolezen
Objavljeno v DKUM: 09.04.2024; Ogledov: 197; Prenosov: 13
Celotno besedilo (113,08 KB)
Gradivo ima več datotek! Več...
Gradivo je zbirka in zajema 1 gradivo! |
7. Atherosclerosis, epigenetic modifications, and arterial stiffnessNejc Piko, Robert Ekart, Sebastjan Bevc, Radovan Hojs, 2017, pregledni znanstveni članek Ključne besede: ateroskleroza, epigenetika, togost arterij
Objavljeno v DKUM: 09.04.2024; Ogledov: 218; Prenosov: 23
Celotno besedilo (111,19 KB)
Gradivo ima več datotek! Več...
Gradivo je zbirka in zajema 1 gradivo! |
8. Subendocardial viability, ambulatory blood pressure monitoring and serum biomarkers for cardiovascular disease in chronic kidney patientsNejc Piko, Tajda Šrot Volavc, Nina Vodošek Hojs, Sebastjan Bevc, Radovan Hojs, Robert Ekart, 2019, izvirni znanstveni članek Ključne besede: arterijska togost, augmentacijksi indeks, kronična ledvičnabolezen, NT-proBNP, razmerje subendokardne viabilnosti miokarda
Objavljeno v DKUM: 04.04.2024; Ogledov: 195; Prenosov: 4
Celotno besedilo (204,97 KB)
Gradivo ima več datotek! Več...
Gradivo je zbirka in zajema 1 gradivo! |
9. The role of oxidative stress in kidney injuryNejc Piko, Sebastjan Bevc, Radovan Hojs, Robert Ekart, 2023, pregledni znanstveni članek Opis: Acute kidney injury and chronic kidney disease are among the most common non-communicable diseases in the developed world, with increasing prevalence. Patients with acute kidney injury are at an increased risk of developing chronic kidney disease. One of kidney injury’s most common clinical sequelae is increased cardiovascular morbidity and mortality. In recent years, new insights into the pathophysiology of renal damage have been made. Oxidative stress is the imbalance favoring the increased generation of ROS and/or reduced body’s innate antioxidant defense mechanisms and is of pivotal importance, not only in the development and progression of kidney disease but also in understanding the enhanced cardiovascular risk in these patients. This article summarizes and emphasizes the role of oxidative stress in acute kidney injury, various forms of chronic kidney disease, and also in patients on renal replacement therapy (hemodialysis, peritoneal dialysis, and after kidney transplant). Additionally, the role of oxidative stress in the development of drug-related nephrotoxicity and also in the development after exposure to various environmental and occupational pollutants is presented.
Ključne besede: acute kidney injury, acute tubular necrosis, chronic kidney disease, oxidative stress, reactive oxygen species
Objavljeno v DKUM: 19.03.2024; Ogledov: 210; Prenosov: 45
Celotno besedilo (1007,69 KB)
Gradivo ima več datotek! Več... |
10. Effects of differential time and difficulty weighting on the improvement of OSCE quality metricsMatic Mihevc, Klara Masnik, Tadej Petreski, Nejc Pulko, Sebastjan Bevc, 2022, izvirni znanstveni članek Ključne besede: OSCE, clinical skills, peer assessment, quality metrics, weighting, outliers
Objavljeno v DKUM: 17.01.2023; Ogledov: 487; Prenosov: 59
Celotno besedilo (309,40 KB)
Gradivo je zbirka in zajema 1 gradivo! |
