1. Editorial: Lactic acid bacteria and their bioactive compounds: key regulators of gut microbiota and immune functionSabina Fijan, Nathalie Connil, Bojana Bogovič Matijašić, Marikunte Yanjarappa Sreenivasa, Marimuthu Anandharaj, 2025, drugi znanstveni članki Opis: This Research Topic aimed to compile articles focusing on new insights into the role of lactic acid bacteria in the regulation of the gut microbiota. The main objectives included were understanding how LAB influence gut microbiota composition, identifying bioactive compounds produced by LAB and their effects, elucidating the molecular mechanisms underlying LAB's impact on immunity, pathogen exclusion, and intestinal barrier function, and exploring potential therapeutic interventions involving LAB. By addressing these questions, the research was aimed to fill existing gaps in our knowledge and provide a comprehensive understanding of LAB's multifaceted roles in gut health and beyond.
Ključne besede: lactic acid bacteria, probiotics, gut microbiota, health, bacteria, fungi
Objavljeno v DKUM: 04.11.2025; Ogledov: 0; Prenosov: 2
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2. Vpliv probiotikov na preprečevanje okužb sečilMaša Wagner, 2025, diplomsko delo Opis: Uvod: Okužbe sečil so najbolj pogosta bakterijska okužba, ki prizadene zlasti ženske. Razlikujemo med zapletenimi in nezapletenimi okužbami sečil. Probiotiki lahko pomagajo pri obnovi naravne mikrobiote sečil. Zaradi dostopnosti in varnosti predstavljajo možno dopolnilno zdravljenje obstoječim pristopom zdravljenja. Namen diplomskega dela je bil raziskati vpliv probiotikov na preprečevanje okužb sečil.
Metode: Izveden je bil pregled znanstvene literature s področja vpliva probiotikov na preprečevanje okužb sečil. Raziskave smo pridobili iz podatkovnih baz PubMed in Cochrane Library. Rezultate smo predstavili v obliki opisne sinteze.
Rezultati: Analizirali smo devet raziskav. V analiziranih študijah so raziskovalci proučevali učinkovitost probiotikov na preprečevanje okužb sečil pri različnih populacijah. Raziskave kažejo na možen vpliv probiotikov pri zmanjševanju okužb sečil, vendar so rezultati med posameznimi študijami različni.
Razprava in zaključek: Probiotiki predstavljajo potencial pri preprečevanju okužb sečil, vendar zaradi nasprotujočih si ugotovitev ne moremo potrditi njihovega učinka pri preprečevanju okužb. Smiselno bi bilo izvesti več kakovostnih randomiziranih kontroliranih raziskav, ki bi bolj natančno raziskale najučinkovitejše probiotične seve, odmerek in trajanje terapije.
Ključne besede: probiotiki, okužbe sečil, preprečevanje okužb sečil
Objavljeno v DKUM: 24.10.2025; Ogledov: 0; Prenosov: 4
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3. Vpliv probiotikov na kakovost življenja pri bolnikih po operaciji možganovDoroteja Pukšič, 2025, diplomsko delo Opis: Uvod: Komunikacijske poti med možgani in mikrobioto omogočajo, da lahko z
dodajanjem probiotikov vplivamo na črevesno mikrobioto in posledično na kognitivne sposobnosti. Namen zaključnega dela je bil raziskati vpliv probiotikov na kakovost življenja pri bolnikih po operaciji možganov.
Metode: Zaključno delo je temeljilo na pregledu literature z uporabo opisne metode dela. Literaturo smo identificirali iz mednarodnih podatkovnih baz PubMed, ScienceDirect, MEDLINE (EBSCOhost) ter Wiley Online Library. Proces iskanja literature je temeljil na vnaprej opredeljenih vključitvenih in izključitvenih kriterijih ter je prikazan z diagramom poteka v skladu s smernicami PRISMA. Kakovost vključenih raziskav smo ocenili na osnovi
hierarhije dokazov. Uporabili smo tematsko analizo in sintezo podatkov.
Rezultati: V končno analizo smo vključili 6 ustreznih člankov. Raziskave kažejo, da probiotiki prinašajo le določene koristi za kakovost življenja pri bolnikih po operaciji možganov, kot so krajši čas hospitalizacije, zmanjšanje markerjev vnetja, zmanjšanje tveganja za okužbe, nižja umrljivost ter hitrejše okrevanje črevesne funkcije po operaciji možganov.
Razprava in zaključek: Kljub številnim blagodejnim učinkom probiotikov na zdravje naš pregled literature kaže na omejen vpliv probiotikov na kakovost življenja bolnikov po operaciji možganov. Za zanesljivejše zaključke pa so potrebne nadaljnje klinične raziskave z večjim številom udeležencev in standardiziranimi metodami ocenjevanja kakovosti življenja.
Ključne besede: koristne črevesne bakterije, kakovost življenja, nevrološki bolniki, operacija možganov
Objavljeno v DKUM: 24.10.2025; Ogledov: 0; Prenosov: 7
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4. The antimicrobial effect of various single-strain and multi-strain probiotics, dietary supplements or other beneficial microbes against common clinical wound pathogensSabina Fijan, Primož Kocbek, Andrej Steyer, Polona Maver Vodičar, Maja Strauss, 2022, izvirni znanstveni članek Opis: The skin is the largest organ in the human body and is colonized by a diverse microbiota that works in harmony to protect the skin. However, when skin damage occurs, the skin microbiota is also disrupted, and pathogens can invade the wound and cause infection. Probiotics or other beneficial microbes and their metabolites are one possible alternative treatment for combating skin pathogens via their antimicrobial effectiveness. The objective of our study was to evaluate the antimicrobial effect of seven multi-strain dietary supplements and eleven single-strain microbes that contain probiotics against 15 clinical wound pathogens using the agar spot assay, co-culturing assay, and agar well diffusion assay. We also conducted genera-specific and species-specific molecular methods to detect the DNA in the dietary supplements and single-strain beneficial microbes. We found that the multi-strain dietary supplements exhibited a statistically significant higher antagonistic effect against the challenge wound pathogens than the single-strain microbes and that lactobacilli-containing dietary supplements and single-strain microbes were significantly more efficient than the selected propionibacteria and bacilli. Differences in results between methods were also observed, possibly due to different mechanisms of action. Individual pathogens were susceptible to different dietary supplements or single-strain microbes. Perhaps an individual approach such as a ‘probiogram’ could be a possibility in the future as a method to find the most efficient targeted probiotic strains, cell-free supernatants, or neutralized cell-free supernatants that have the highest antagonistic effect against individual clinical wound pathogens.
Ključne besede: probiotics, beneficial microbes, wound pathogens, skin pathogens, agar spot, co-culturing, agar well diffusion, molecular methods, PCR
Objavljeno v DKUM: 23.10.2025; Ogledov: 0; Prenosov: 3
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5. Study of the in vitro antagonistic activity of various single-strain and multi-strain probiotics against Escherichia coliSabina Fijan, Dunja Šulc, Andrej Steyer, 2018, izvirni znanstveni članek Opis: Escherichia coli is an important commensal of our gut, however, many pathogenic strains exist, causing various severe infections in the gut or beyond. Due to several antibiotic resistance patterns of E. coli, research of alternative treatments or adjuvant therapy is important. One of these is the use of probiotics as antagonistic agents against E. coli. Most published studies investigate only one strain of E. coli and single-strain probiotics. The objectives of this study were to evaluate the antagonistic activity of selected single-strain and multi-strain probiotic supplements against selected clinical E. coli pathotypes using the in vitro agar spot test and the co-culturing method. Molecular methods were used to determine the presence of the genus lactobacilli and bifidobacteria as well as certain selected strains in the probiotic supplements. The agar-spot test showed that the multi-strain probiotics were more effective than the single-strain probiotics. On the other hand, the co-culturing method showed the opposite result, indicating that results are importantly influenced by the chosen method. The most effective single-strain probiotics against E. coli strains were Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus reuteri DSM 17938. The most effective multi-strain probiotics contained lactobacilli, bifidobacteria and enterococci strains, thus proving that most effective probiotics against E. coli strains are the lactic acid bacteria and bifidobacteria. The overall results from both in vitro tests reveal that all selected probiotics exhibited an antagonistic activity against all E. coli strains. From a public health perspective probiotics have thus proved to be successful in inhibiting the growth of E. coli and could therefore be used as adjuvant therapy or alternative therapy in E. coli infections.
Ključne besede: probiotic, Escherichia coli, antagonistic effect
Objavljeno v DKUM: 23.10.2025; Ogledov: 0; Prenosov: 6
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6. Overview of probiotic strains of Weizmannia coagulans, previously known as Bacillus coagulans, as food supplements and their use in human healthSabina Fijan, Tamara Fijan, Nathalie Connil, 2023, pregledni znanstveni članek Opis: Weizmannia coagulans, previously known as Bacillus coagulans and before that as Lactobacillus sporogenes, is a spore-forming, lactic acid-producing, Gram-positive, bacillus-shaped bacterial species with several known probiotic strains, including GBI-30, 6086 Unique IS-2, MTCC 5856, LBSC (DSM 17654), TBC169, SNZ 1969, BC30, and T11. This review focusses on the health benefit of these strains. A total of 53 clinical trials were found to use various strains of Weizmannia coagulans. However, 19 of these clinical trials did not provide strain information. Clinical evidence has shown that supplementation with strains of Weizmannia coagulans resulted in statistically significant health effects in the probiotic groups compared to the placebo. Several health benefits of the Weizmannia coagulans strains were found including relieving symptoms of irritable bowel syndrome, constipation, diarrhoea, and other gastrointestinal symptoms, function recovery treatment of non-fatty liver disease, after surgery or in patients with rheumatoid arthritis, quality of life and glucose- and lipid-related biomarkers related to overweight or obese participants or diabetic patients, absorption of protein or muscle integrity and improvement of peri- and post-menopausal symptoms. The main mechanism of action is the modulation of the intestinal microbiota and host immunity. However, in terms of several clinical studies involving small patient populations, others did not provide strain information. Larger, well-designed clinical studies are warranted to support the health benefits of Weizmannia coagulans strains.
Ključne besede: spore-forming bacteria, probiotics, Bacillus coagulans, Weizmannia coagulans
Objavljeno v DKUM: 23.10.2025; Ogledov: 0; Prenosov: 1
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7. Health benefits of kimchi, sauerkraut, and other fermented foods of the genus BrassicaSabina Fijan, Polona Fijan, Lei Wei, Maria L. Marco, 2024, pregledni znanstveni članek Opis: Fermented foods made through microbial growth and enzymatic conversions have been integral to human diets for at least 10,000 years. Recent interest in fermented foods has surged due to their functional properties and health benefits. Cruciferous vegetables of the genus Brassica, such as cabbage, broccoli, and cauliflower, are commonly used to produce fermented foods like sauerkraut, kimchi, pao cai, fermented turnips, and others. These foods are rich in lactic acid bacteria (LAB) and bioactive compounds, which contribute to their potential health-promoting properties. We examined 12 clinical trials investigating fermented foods of the genus Brassica. These studies, which mainly assessed the health benefits of kimchi or sauerkraut consumption, found that regular intake can alleviate symptoms of irritable bowel syndrome (IBS), aid weight loss, and enhance metabolic health. Seven observational studies also observed health benefits when consuming fermented foods of the genus Brassica. Six of the seven observational studies on kimchi intake linked kimchi intake to reduced obesity risk and other health benefits. An observational study linked sauerkraut and cabbage consumption to reduced breast cancer risk. Despite these findings, the exact roles of various microorganisms and bioactive compounds within these health effects require further investigation. This review underscores the potential of fermented cruciferous vegetables as functional foods, and advocates for more clinical trials and mechanistic studies to understand and optimize their health benefits.
Ključne besede: fermented vegetables, Brassica, fermented cabbage, kimchi, sauerkraut
Objavljeno v DKUM: 23.10.2025; Ogledov: 0; Prenosov: 1
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8. Current Trends in the Applications of Probiotics and Other Beneficial Microbes: Expanding HorizonsSabina Fijan, Tamara Fijan, 2025, drugi znanstveni članki Opis: While pathogenic microbes, such as Yersinia pestis, Mycobacterium tuberculosis, Clostridium tetani, influenza A virus, and many others, have historically been the focus of scientific attention due to their role in causing severe diseases, beneficial microorganisms are being increasingly recognized for their essential contributions to human, animal, and plant health within the One Health framework, as well as their contributions to nutrition and the stability of ecosystems [...]
Ključne besede: probiotics, beneficial microbes, application
Objavljeno v DKUM: 20.10.2025; Ogledov: 0; Prenosov: 1
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Gradivo ima več datotek! Več... |
9. Vpliv uživanja kimčija na zdravjeKlara Žižek, 2025, diplomsko delo Opis: Uvod: Kimči je fermentirana korejska jed, bogata s koristnimi mikroorganizmi, vitamini in minerali, ki izboljšuje prebavo, krepi imunski sistem ter preprečuje bolezni. Kljub vsebnosti natrija ponuja številne zdravstvene koristi in bi lahko postala del vsakodnevne prehrane. Namen zaključnega dela je ugotoviti, kako fermentirano živilo kimči vpliva na posameznikovo zdravje.
Metode: Za iskanje strokovne literature na temo vpliva uživanja kimčija na zdravje smo uporabili različne podatkovne baze, kot so: PubMed, ScienceDirect, CINAHL in BioMed Central. Vso izbrano literaturo smo prikazali z uporabo diagrama PRISMA.
Rezultati: V zaključnem delu smo od 273 raziskav za temeljitejši pregled literature uporabili šest člankov, ki smo jih vključili v nadaljnjo analizo. Na podlagi vključenih člankov smo ugotovili, da ima živilo kimči več pozitivnih kot negativnih lastnosti ter da uživanje kimčija lahko izboljša zdravje, zmanjša telesno maščobo, holesterol, krvni tlak in podpira črevesno mikrobioto.
Razprava in zaključek: Kimči je hranljivo živilo, bogato z vitamini, minerali in vlakninami, ki podpira prebavo in krepi imunski sistem. Ob rastoči ozaveščenosti o zdravih prehranskih izbirah bi širša vključitev kimčija v vsakodnevno prehrano pripomogla k izboljšanju zdravja ljudi in spodbujanju naravnih, hranljivih živil.
Ključne besede: fermentirana živila, kimči, vpliv, zdravje, sol
Objavljeno v DKUM: 21.08.2025; Ogledov: 0; Prenosov: 16
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