1. Initiation and elongation factor co-expression correlates with recurrence and survival in epithelial ovarian cancerMonika Sobočan, Daniela Brunialti, S Sprung, Christoph Schatz, Jure Knez, Rajko Kavalar, Iztok Takač, Johannes Haybaeck, 2022, izvirni znanstveni članek Opis: High grade epithelial ovarian cancer (EOC) represents a diagnostic and therapeutic challenge due to its aggressive features and short recurrence free survival (RFS) after primary treatment. Novel targets to inform our understanding of the EOC carcinogenesis in the translational machinery can provide us with independent prognostic markers and provide drugable targets. We have identified candidate eukaryotic initiation factors (eIF) and eukaryotic elongation factors (eEF) in the translational machinery for differential expression in EOC through in-silico analysis. We present the analysis of 150 ovarian tissue microarray (TMA) samples on the expression of the translational markers eIF2α, eIF2G, eIF5 (eIF5A and eIF5B), eIF6 and eEF1A1. All translational markers were differentially expressed among non-neoplastic ovarian samples and tumour samples (borderline tumours and EOC). In EOC, expression of eIF5A was found to be significantly correlated with recurrence free survival (RFS) and expression of eIF2G and eEF1A1 with overall survival (OS). Expression correlation among factor subunits showed that the correlation of eEF1A1, eIF2G, EIF2α and eIF5A were significantly interconnected. eIF5A was also correlated with eIF5B and eIF6. Our study demonstrates that EOCs have different translational profile compared to benign ovarian tissue and that eIF5A is a central dysregulated factor of the translation machinery.
Ključne besede: epithelial ovarian cancer, initiation and elongation factor, translational markers
Objavljeno v DKUM: 12.12.2024; Ogledov: 0; Prenosov: 0
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2. Clinical reasoning needs to be explicitly addressed in health professions curricula : recommendations from a European consortiumIoannis Parodis, Lina Andersson, Steven J. Durning, Inga Hege, Jure Knez, Andrzej Kononowicz, Marie Lidskog, Tadej Petreski, Magdalena Szopa, Samuel Edelbring, 2021, izvirni znanstveni članek Opis: Clinical reasoning entails the application of knowledge and skills to collect and integrate information, typically with the goal of arriving at a diagnosis and management plan based on the patient’s unique circumstances and preferences. Evidence-informed, structured, and explicit teaching and assessment of clinical reasoning in educational programs of medical and other health professions remain unmet needs. We herein summarize recommendations for clinical reasoning learning objectives (LOs), as derived from a consensus approach among European and US researchers and health professions educators. A four-step consensus approach was followed: (1) identification of a convenience sample of the most relevant and applied national LO catalogues for health professions educational programs (N = 9) from European and US countries, (2) extraction of LOs related to clinical reasoning and translation into English, (3) mapping of LOs into predefined categories developed within the Erasmus+ Developing, implementing, and disseminating an adaptive clinical reasoning curriculum for healthcare students and educators (DID-ACT) consortium, and (4) synthesis of analysis findings into recommendations for how LOs related to clinical reasoning could be presented and incorporated in LO catalogues, upon consensus. Three distinct recommendations were formulated: (1) make clinical reasoning explicit, (2) emphasize interprofessional and collaboration aspects of clinical reasoning, and (3) include aspects of teaching and assessment of clinical reasoning. In addition, the consortium understood that implementation of bilingual catalogues with English as a common language might contribute to lower heterogeneity regarding amount, structure, and level of granularity of clinical reasoning LOs across countries. These recommendations will hopefully motivate and guide initiatives towards the implementation of LOs related to clinical reasoning in existing and future LO catalogues.
Ključne besede: clinical reasoning, curriculum development, curriculum mapping, health professions education, medical education
Objavljeno v DKUM: 08.10.2024; Ogledov: 0; Prenosov: 1
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3. Contemporary approach to diagnostics in women with suspected pelvic endometriosisJure Knez, Andraž Dovnik, Maja Pakiž, Igor But, Milan Reljič, Vida Gavrić-Lovrec, Maja Banović, Iztok Takač, 2019, pregledni znanstveni članek Ključne besede: endometriosis, endometrioma, ovarian cysts, deep pelvic endometriosis, ultrasound, pelvic pain
Objavljeno v DKUM: 27.03.2024; Ogledov: 258; Prenosov: 12
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4. Ultra-high-risk gestational choriocarcinoma of the ovary associated with ectopic pregnancyEva Pavla Malovrh, Nuša Lukinovič, Tatjana Bujas, Monika Sobočan, Jure Knez, 2023, drugi znanstveni članki Opis: Gestational choriocarcinoma of the ovary is an exceptionally rare and highly aggressive tumor. Preoperative diagnosis of extrauterine choriocarcinoma is difficult due to nonspecific clinical presentation and its resemblance to ectopic pregnancy. Without molecular genetic analysis, it is not possible to reliably differentiate gestational from non-gestational choriocarcinoma. Here, we present a case of a 44-year-old woman who presented to our emergency department with complaints of pelvic pain, vaginal bleeding, and amenorrhea. Because of a recent history of conservatively managed ectopic pregnancy, the patient underwent emergency laparoscopy. Right-sided salpingo-oophorectomy was performed due to intraoperatively suspected ovarian ectopic pregnancy. Histopathology results revealed the diagnosis of ovarian choriocarcinoma of possible gestational origin. It was classified as FIGO stage IV and WHO ultra-high-risk, and she underwent multi-agent chemotherapy without major complications. She has remained in complete remission after a 12-month follow-up. Considering the rarity of this diagnosis, we conducted a literature review including all published cases of suspected gestational choriocarcinomas of the ovary. We conclude that due to the rarity of this entity, preoperative differentiating between ovarian ectopic pregnancy and ovarian choriocarcinoma is extremely challenging, and without molecular genetic analysis, it is not possible to identify the genetic origin of the tumor.
Ključne besede: ovarian choriocarcinoma, gestational trophoblastic neoplasia
Objavljeno v DKUM: 21.02.2024; Ogledov: 302; Prenosov: 9
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9. Vodenje pogona transporterja skladno z zakonodajo o varnosti strojev : diplomsko deloJure Knez, 2021, diplomsko delo Opis: Med izgorevanjem in čiščenjem dimnih plinov v termoelektrarni nastajajo stranski produkti, ki jih je potrebno transportirati na deponije. Za ta namen uporabljamo transportne sisteme, ki so opisani v diplomski nalogi.
V prvem delu je opis standardov, ki jih je bilo potrebno upoštevati pri izdelavi. V nadaljevanju je opis termoelektrarne Ugljevik in opis elementov enega od transporterjev. Sledi podroben opis transporterja G-1 ter njegov način vodenja.
V zadnjem delu sta predstavljena še dva možna načina vodenja, ki sta izrisana s pomočjo programskega paketa EPLAN, kateri je tudi na kratko opisan. Predstavljene so prednosti in slabosti posameznih tipov vodenja.
Ključne besede: standardizacija, standardi, termoelektrarna, vodenje pogona transporterja
Objavljeno v DKUM: 18.10.2021; Ogledov: 816; Prenosov: 54
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10. From DCOM interfaces to domain-specific modeling language : a case study on the sequencerTomaž Kos, Tomaž Kosar, Jure Knez, Marjan Mernik, 2011, izvirni znanstveni članek Opis: Software development is a demanding process, since it involves different parties to perform a desired task. The same case applies to the development ofmeasurement systems - measurement system producers often provide interfaces to their products, after which the customersć programming engineers use them to build software according to the instructions and requirements of domain experts from the field of data acquisition. Until recently, the customers of the measurement system DEWESoft were building measuring applications, using prefabricated DCOM objects. However, a significant amount of interaction between customersć programming engineers and measurement system producers is necessary to use DCOM objects. Therefore, a domain-specific modeling language has been developed to enable domain experts to program or model their own measurement procedures without interacting with programming engineers. In thispaper, experiences gained during the shift from using the DEWESoft productas a programming library to domain-specific modeling language are provided together with the details of a Sequencer, a domain-specific modeling language for the construction of measurement procedures.
Ključne besede: domain specific modelling language, data acquisition, measurement systems
Objavljeno v DKUM: 06.07.2017; Ogledov: 1574; Prenosov: 191
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