Iskanje po katalogu digitalne knjižnice

Opis: During the corona virus (COVID-19) pandemic, there was a sharp increase in the need for diagnostic tests that could detect the presence of SARS-CoV-2 virus or its antibodies quickly and reliably. An important type in the group of diagnostic tests are rapid antigen lateral flow immuno-assay (LFIA) tests, which operate on the immuno-chromatographic principle with the lateral flow of analyte. Clinical practice in the last year has shown that such diagnostic tests can be effective in preventing the spread of the SARS-CoV-2 virus.The development, and, thus, the production of the rapid antigen LFIA tests, is influenced by a number of factors that determine their sensitivity and accuracy indirectly. These factors are directly dependent on the type of antibody produced, which is formed as an immune response when infected with the virus. The production of the rapid antigen LFIA tests is associated with the appropriate selection of basic components that determine the type and quality of these tests. The basic components include: substrates and membranes, antigens, antibody labels and compatible buffers. The correct choice of membranes and their materials is crucial to compiling an effective rapid antigen LFIA test. This study therefore presents a comparative analysis of four commercially available SARS-CoV-2-rapid LFIA tests using state-of-the-art characterisation techniques scanning electron microscopy (SEM), inductively coupled plasma-optical emission spectrometry (ICP-OES), environmental scanning electron microscope / energy-dispersive X-ray spectroscopy (ESEM/EDX), Fourier-transform infrared spectroscopy / attenuated total reflection (FTIR/ATR) for the individual components. The obtained results were the starting point for the development and assembling of our own rapid antigen LFIA test based on gold nanoparticles as antibody labels.
Ključne besede: hitri antigenski testi, komponente, karakterizacija, analize, rapid antigen test, components, characterisation, analysis
Objavljeno v DKUM: 26.03.2025; Ogledov: 0; Prenosov: 3
Povezava na celotno besedilo
Gradivo ima več datotek! Več...

Opis: A complex concentrated noble alloy (CCNA) of equiatomic composition (Ag20Pd20Pt20Cu20Ni20 –20 at. %) was studied as a potential high—performance material. The equiatomic composition was used so that this alloy could be classified in the subgroup of high—entropy alloys (HEA). The alloy was prepared by induction melting at atmospheric pressure, using high purity elements. The degree of metastability of the cast state was estimated on the basis of changes in the microstructure during annealing at high temperatures in a protective atmosphere of argon. Characterisation of the metallographically prepared samples was performed using a scanning electron microscope (SEM) equipped with an energy dispersive spectrometer (EDS), differential scanning calorimetry (DSC), and X–ray diffraction (XRD). Observation shows that the microstructure of the CCNA is in a very metastable state and multiphase, consisting of a continuous base of dendritic solidification—a matrix with an interdendritic region without other microstructural components and complex spheres. A model of the probable flow of metastable solidification of the studied alloy was proposed, based on the separation of L—melts into L1 (rich in Ni) and L2 (rich in Ag). The phenomenon of liquid phase separation in the considered CCNA is based on the monotectic reaction in the Ag−Ni system.
Ključne besede: complex concentrated noble alloy, high—entropy alloy, metastability
Objavljeno v DKUM: 20.03.2025; Ogledov: 0; Prenosov: 7
Celotno besedilo (4,00 MB)
Gradivo ima več datotek! Več...

Opis: Skripta, Sodobni inženirski materiali je kot temeljno študijsko gradivo namenjeno pervenstveno študentom 2. stopnje študijskih programov Strojništva, Gospodarskega inženirstva, Mehatronike in študentom Inženirsko oblikovanja izdelkov. Skripta je sestavljena iz treh poglavij: (i) Zgradba in izbira inženirskih materialov; (ii) Lastnosti inženirskih materialov; (iii) Primeri sodobnih inženirskih materialov. V prvem poglavju je obravnavana zgradba kovinskih, keramičnih, polimernih in kompozitnih materialov ter predstavljeni so kriteriji, ki omogočajo inženirjem glede na želeno kombinacijo lastnosti materialov, njihovo ustrezno izbiro za določeno aplikacijo. Drugo poglavje obravnava lastnosti sodobnih inženirskih materialov s poudarkom na poglobljenem študiju razlage korelacij med zgradbo, mikrostrukturo in lastnostmi. V zadnjem najobsežnejšem poglavju so predstavljeni izbrani primeri sodobnih inženirskih materialov, katerih uporaba e v industrijski praksi dandanes zelo aktualna. Če naštejemo samo najbolj zanimive: disperzijsko utrjeni materiali, spominske zlitine, konstrukcijska keramika, materiali za shranjevanje vodika, hitrostrjeni kovinski materiali, sodobne aluminijeve zlitine, biopolimeri in še mnogi drugi.
Ključne besede: sodobni inženirski materiali, zgradba, izbira materialov, mikrostruktura, lastnosti
Objavljeno v DKUM: 27.02.2025; Ogledov: 0; Prenosov: 750
Celotno besedilo (22,61 MB)
Gradivo ima več datotek! Več...

Opis: A high-noble Au–Pt–Ge porcelain-fused-to-metal (PFM) dental alloy without the known adverse metallic elements and with the addition of germanium (Ge) was produced as a more cost-effective alternative to other precious alloying metals, with investigations for determining the functionality and clinical use of this alloy. The thermomechanical, biocompatibility, durability, workability and economic characteristics of the produced dental alloy were investigated. These properties were investigated with in vitro biocompatibility testing on human gingival fibroblasts (HGFs); static immersion testing for metal ion release; DSC analysis; hardness, tensile testing, density and coefficient of thermal expansion (CTE) measurements; metallographic and SEM/EDX microstructure investigations; and finally with the production of a test PFM dental bridge. The results of the thermomechanical testing showed alloy properties suitable for dental restorations and clinical use, with somewhat lower mechanical properties, making the alloy not suitable for extensive multiunit fixed restorations. The microstructure investigations showed segregations of Ge in the homogeneous alloy matrix, which reduce the alloy’s mechanical properties. The produced PFM dental bridge showed excellent workability of the alloy in a dental laboratory setting, as well as a high standard of the final dental restoration. The ion release was negligible, well below any harmful quantities, while the cell viability examination showed significantly higher viability ratings on polished alloy samples as compared to as-cast samples. The results showed that a dental substructure in direct contact with oral tissue and fluids should be highly polished. The performed investigations showed that the produced PFM dental alloy is suitable for clinical use in producing high-quality dental restorations with high biocompatibility for patients prone to metal allergies
Ključne besede: noble metal dental alloys, metal–ceramic alloys, materials testing, biocompatibility testing
Objavljeno v DKUM: 25.11.2024; Ogledov: 0; Prenosov: 8
Celotno besedilo (11,75 MB)
Gradivo ima več datotek! Več...

Opis: A coupled process of ultrasonic spray pyrolysis and lyophilisation was used for the synthesis of dried gold nanoparticles. Two methods were applied for determining their melting temperature: uniaxial microcompression and differential scanning calorimetry (DSC) analysis. Uniaxial microcompression resulted in sintering of the dried gold nanoparticles at room temperature with an activation energy of 26–32.5 J/g, which made it impossible to evaluate their melting point. Using DSC, the melting point of the dried gold nanoparticles was measured to be around 1064.3°C, which is close to pure gold. The reason for the absence of a melting point depression in dried gold nanoparticles was their exothermic sintering between 712 and 908.1°C.
Ključne besede: gold nanoparticles, melting point, ultrasonic spray pyrolysis, characterisation
Objavljeno v DKUM: 08.12.2023; Ogledov: 448; Prenosov: 32
Celotno besedilo (2,83 MB)
Gradivo ima več datotek! Več...