1. Energy intake models for intermittent operation of dead-end microfiltration filling lineJure Ravnik, Gorazd Bombek, Aleš Hribernik, Timi Gomboc, Matej Zadravec, Aleks Kapun, Grega Hrovat, Jure Gradišek, Matjaž Hriberšek, 2022, izvirni znanstveni članek Opis: In filling lines equipped with membrane separation devices in the form of filters energy,
consumption is only one of the important working parameters, the other being sustainable filter
performance in terms of separation efficiency. As the filling line is typically equipped with a valve,
intermittent operation of the filter is an important form of its use. Whereas the overall energy
consumption of the filtration process is governed by the continuous operation mode, the intermittent
mode, characterised by opening/closing of the valve, contributes most to problems of filter failure,
i.e., the breakthrough of filtered particles through the membrane. A model for determination of the
energy intake of a microfiltration membrane during the opening and closing of a valve is presented
in this work. The model is based on computational analysis of the pressure wave signals recorded
during the opening/closing of the valve using Fourier transform, and expressed in a nondimensional
filter area specific energy intake form. The model is applied to a case of constant pressure dead-end
microfiltration with three filter types: a single membrane filter, a stacked filter and a pleated filter
with filtration surface areas ranging from 17.7 cm2
to 2000 cm2. Both clean filters, as well as partially clogged filter cases are taken into account. Second order polynomial models of the energy intake are developed and evaluated based on extensive analysis of the experimental data. The analysis of energy intake results show that the largest energy intake was observed for the clean filter case. When membrane fouling occurs at the constant flow rate values it leads to larger energy intake, however,
due to a decreasing specific flow rate during fouling these values do not exceed the clean filter case.
Ključne besede: membrane filtration, water hammer effect, membrane energy intake, filter clogging
Objavljeno v DKUM: 28.03.2025; Ogledov: 0; Prenosov: 1
 Celotno besedilo (4,01 MB)
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2. Development of an experimental Dead-End microfiltration layout and process repeatability analysisGorazd Bombek, Luka Kevorkijan, Grega Hrovat, Drago Kuzman, Aleks Kapun, Jure Ravnik, Matjaž Hriberšek, Aleš Hribernik, 2024, izvirni znanstveni članek Opis: Microfiltration is an important process in the pharmaceutical industry. Filter selection and validation is a time-consuming and expensive process. Quality by design approach is important for product safety. The article covers the instrumentalization and process control of a laboratory-scale dead-end microfiltration layout. The layout is a downscale model of the actual production line, and the goal is filter validation and analysis of process parameters, which may influence filter operation. Filter size, fluid pressure, valve plunger speed, and timing issues were considered. The focus is on the identification of the most influential process parameters and their influence on the repeatability of pressure oscillations caused by valve opening. The goal was to find the worst-case scenario regarding pressure oscillations and, consequently, filter energy intake. The layout was designed as compact as possible to reduce pressure losses between the filter and valve. Valve-induced pressure oscillations proved to be prevailing over the water hammer effect. Several filters in sizes between 3.5 cm2 and 6900 cm2 were tested, and some recommendations were suggested for the reduction of energy intake of the filter and to improve the repeatability of the process.
Ključne besede: filtration, pressure oscillations, repeatability, processes, parameters
Objavljeno v DKUM: 01.02.2024; Ogledov: 425; Prenosov: 36
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