1. Ribotype classification of Clostridioides difficile isolates Is not predictive of the amino acid sequence diversity of the toxin virulence factors TcdA and TcdBZhenghui Li, Kwok Lee, Urvi Rajyaguru, C. Hal Jones, Sandra Janežič, Maja Rupnik, Annaliesa S. Anderson, Paul Liberator, 2020, izvirni znanstveni članek Opis: Clostridioides (Clostridium) difficile is the most commonly recognized cause of infectious diarrhea in healthcare settings. Currently there is no vaccine to prevent initial or recurrent C. difficile infection (CDI). Two large clostridial toxins, TcdA and TcdB, are the primary virulence factors for CDI. Immunological approaches to prevent CDI include antibody-mediated neutralization of the cytotoxicity of these toxins. An understanding of the sequence diversity of the two toxins expressed by disease causing isolates is critical for the interpretation of the immune response to the toxins. In this study, we determined the whole genome sequence (WGS) of 478 C. difficile isolates collected in 12 countries between 2004 and 2018 to probe toxin variant diversity. A total of 44 unique TcdA variants and 37 unique TcdB variants were identified. The amino acid sequence conservation among the TcdA variants (>98%) is considerably greater than among the TcdB variants (as low as 86.1%), suggesting that different selection pressures may have contributed to the evolution of the two toxins. Phylogenomic analysis of the WGS data demonstrate that isolates grouped together based on ribotype or MLST code for multiple different toxin variants. These findings illustrate the importance of determining not only the ribotype but also the toxin sequence when evaluating strain coverage using vaccine strategies that target these virulence factors. We recommend that toxin variant type and sequence type (ST), be used together with ribotype data to provide a more comprehensive strain classification scheme for C. difficile surveillance during vaccine development objectives.
Ključne besede: Clostridioides difficile, Clostridium difficile, TCDB, TcdA, vaccines, whole genome sequencing
Objavljeno v DKUM: 28.01.2025; Ogledov: 0; Prenosov: 5
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2. Rural amenity and rural change in temperate Australia : implications for development and sustainabilityNeil Argent, Matthew Tonts, Roy Jones, John Hubert Holmes, 2009, izvirni znanstveni članek Opis: Many rural areas in the developed world are experiencing planning and development challenges related to processes of population change. The nature, direction and regional manifestations of these changes are strongly related to the varying levels of local amenity. These result from the qualities of the local social, economic and physical environments and contribute to the ability of rural regions to attract and retain residents. In turn the presence or absence of this attractive ability is likely to engender development and sustainability challenges related to growth, decline or (where the attractive forces are demographically specific) social mix. This paper considers these challenges in the context of high amenity rural regions in temperate Australia.
Ključne besede: rural amenity, migration, temperate Australia, counter urbanisation, demographic change
Objavljeno v DKUM: 20.03.2018; Ogledov: 1412; Prenosov: 84
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5. The advertising business : operations, creativity, media planning, integrated communicationszbornik Ključne besede: advertising, agencies, business, USA, legislation, mass media, medium, mass communication, ethics, executives, sales promotion
Objavljeno v DKUM: 01.06.2012; Ogledov: 1718; Prenosov: 111
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6. Knowledge capitalism : business, work, and learning in the new economyAlan Burton-Jones, 1999, priročnik Ključne besede: knowledge, management, capitalism, theory, support, empirical research, data, data sources, working organization, industrialization, human capital, intelligent systems, business, business operation of the enterprise, socio-economic development, contemporary society, work, learning, new economy, enterprise, property, control, restructuring, individualism, employment, supply, models, career success, career, entrepreneur, dependences, independence, business cooperation, networks, boundary, transition economics
Objavljeno v DKUM: 01.06.2012; Ogledov: 2674; Prenosov: 49
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7. Investment appraisal and financial decisionsSteve Lumby, Chris Jones, 1999, učbenik za višje in visoke šole Ključne besede: investicije, vrednotenje, ocenjevanje, poslovne finance, finančni management, finančni instrumenti, strateško planiranje, modeli, opazovanje, delovna organizacija, rizični kapital, obresti, trg kapitala, donos, stroški, premoženje, odločanje, investicijsko odločanje, struktura, poslovne odločitve, denarni tokovi, tveganje, opcije, finančno odločanje, finančna analiza, učinkovitost, portfolio, vrednost, metode, rešitve, pogoji gospodarjenja, primeri, case study, učbeniki
Objavljeno v DKUM: 01.06.2012; Ogledov: 2367; Prenosov: 72
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