1. Family history tools for primary care : a systematic reviewŠpela Miroševič, Zalika Klemenc-Ketiš, Borut Peterlin, 2022, pregledni znanstveni članek Opis: Background: Many medical family history (FH) tools are available for various settings. Although FH tools can be a powerful health screening tool in primary care (PC), they are currently underused.
Objectives: This review explores the FH tools currently available for PC and evaluates their clinical performance. Methods: Five databases were systematically searched until May 2021. Identified tools were evaluated on the following criteria: time-to-complete, integration with electronic health record (EMR) systems, patient administration, risk-assessment ability, evidence-based management recommendations, analytical and clinical validity and clinical utility.
Results: We identified 26 PC FH tools. Analytical and clinical validity was poorly reported and agreement between FH and gold standard was commonly inadequately reported and assessed. Sensitivity was acceptable; specificity was found in half of the reviewed tools to be poor. Most reviewed tools showed a capacity to successfully identify individuals with increased risk of disease (6.2-84.6% of high and/or moderate or increased risk individuals). Conclusion: Despite the potential of FH tools to improve risk stratification of patients in PC, clinical performance of current tools remains limited as well as their integration in EMR systems. Twenty-one FH tools are designed to be self-administered by patients.
Ključne besede: genetics, family medicine, meta-analyses
Objavljeno v DKUM: 17.07.2023; Ogledov: 383; Prenosov: 11
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2. Family history as a predictor for disease risk in healthy individuals : a cross-sectional study in SloveniaZalika Klemenc-Ketiš, Borut Peterlin, 2013, izvirni znanstveni članek Opis: Background Family history can be used as a genetic risk predictor for common non-communicable diseases. The aim of this study was to determine the prevalence of healthy individuals at risk of developing these diseases, based on their self-reported family history.Methods and Findings This was a cross-sectional observational study. Data were collected in the three largest occupational practices in primary health care centres in Slovenia, a Central European country. The study population consisted of consecutive individuals who came to occupational practices for their regular preventive check-up from November 2010 to June 2012. We included 1,696 individuals. Data were collected by a self-developed questionnaire. The main outcome was the number of participants at a moderate or high risk for the development of cardiovascular diseases, diabetes, and cancer.The final sample consisted of 1,340 respondents. Moderate or high risk for the development of cardiovascular diseases was present in 280 (20.9%) participants, for the development of diabetes in 154 (11.5%) participants and for cancer in 163 (12.1%) participants. Conclusions In this study, we found a significant proportion of healthy individuals with an increased genetic risk for common non-communicable diseases; consequently further genetic and clinical evaluation and preventive measures should be offered.
Ključne besede: family history, predictor for disease risk, sectional study in Slovenia
Objavljeno v DKUM: 19.06.2017; Ogledov: 1195; Prenosov: 174
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3. Family physicians' management of genetic aspects of a cardiac disease : a scenario-based study from SloveniaZalika Klemenc-Ketiš, Borut Peterlin, 2014, izvirni znanstveni članek Opis: The aim of this study was to find out how Slovenian family physicians (FPs) would manage a hypothetical clinical case, to explore their views about possible ethical dilemmas associated with this clinical case and to determine possible associations with demographic and other characteristics of FPs. This was an observational cross-sectional postal study in the Slovenian FPs’ surgeries. The study population consisted of the whole population of Slovenian FPs (n = 950). The main outcome measures were the percentages of the answers of FPs on different questions about the clinical case on the management of patient and his relative with hereditary cardiomyopathy. There were 271 FPs who answered the questionnaire (response rate was 27.1%). A sample included 66 (24.4%) men and the mean age of all respondents was 45.5 ± 10.6 years. When dealing with the clinical case, most FPs expressed willingness to take the patient’s family history. Only 34.2% FPs did not believe that ordering genetic tests was part of their job. Additionally, only 50.0% of them felt competent to interpret the genetic risk, 25.0% of them would give information about genetic testing and only 6.0% would interpret the results of the genetic testing. Family physicians in Slovenia were willing to include genetic tasks into routine management of their patients, but they do not feel competent enough to interpret the genetic risks and the results of genetic testing. However, an important part of FPs would not refer patients at risk to genetic counseling. The inclusion of genetic topics to family medicine specialization curriculum is needed.
Ključne besede: case management, family medicine, genetics
Objavljeno v DKUM: 30.03.2017; Ogledov: 1972; Prenosov: 194
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4. Correlates of depression in the slovenian working populationZalika Klemenc-Ketiš, Borut Peterlin, 2013, izvirni znanstveni članek Opis: This multicentre, cross-sectional observational study aimed to determine the prevalence of depression among the working population of Slovenia and identify factors correlating with higher prevalence of depression. It was conducted in three occupational medicine practices within major Slovenian primary health care centres. The study population consisted of 1,474 respondents [73.7 % of the invited participants, 889 (60.3 %) men and 585 (39.7 %) women with mean age of (40.5±9.8) years] who visited these practices for their regular check-ups from November 2010 to June 2012 and were asked to fill in a self-developed questionnaire and score depression on the Zung’s self-rating depression scale. According to the rating, 50 (3.4 %) respondents suffered from depression. In the multivariate analysis, depression correlated with the following independent variables: self-perceived exposure to chronic stress, positive family history of depression, and primary school education.
Ključne besede: mental diseases, primary health care, cross-sectional study, demographic data, family history
Objavljeno v DKUM: 30.03.2017; Ogledov: 1420; Prenosov: 361
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6. UPORABA TEHNIČNE ANALIZE NA LJUBLJANSKI BORZIBorut Peterlin, 2009, diplomsko delo Opis: Tehnična analiza se ukvarja s predvidevanjem prihodnosti. Četudi prihodnjega gibanja tečajev ne more napovedati nihče, ne gre pri pravilni uporabi tehnične analize in ob upoštevanju načel upravljanja z denarnimi sredstvi za hazardiranje. Trgovanje, pri katerem povečujemo verjetnost, da se bo tečaj obrnil v našo korist, imenujemo premišljena investicija. Začetki tehnične analize segajo daleč v preteklost, a se je njena prava moč pokazala komaj z razvojem zmogljivejših računalnikov, ki lahko procesirajo velike količine podatkov v zanemarljivo kratkem času. Je pripomoček za ocenjevanje psihološkega stanja udeležencev na borznih parketih, katerega rezultate je potrebno jemati z distanco, kadar se tečaji delnic obrnejo v neželeno smer.
Empirični del, v katerem smo preizkušali uporabnost tehnične analize na ljubljanski borzi, je pokazal, da je s pravilnim pristopom mogoče doseči donose, ki presegajo donose pasivne strategije kupi in drži. Res pa je, da sama uporabe tehnične analize še nikakor ne zagotavlja uspeha. Vse trgovalne strategije in indikatorje je potrebno predhodno preizkusiti in ugotoviti ali so primerni za določen trg, saj že majhne razlike v njihovih nastavitvah lahko odločajo ali bomo iz trga izstopili kot zmagovalec ali kot poraženec. Ker noben trgovalni sistem ni popoln, je potrebno za dolgoročni uspeh uporabljati zaščitne točke. Te določajo mejo med še sprejemljivim tveganjem in nepotrebno izgubo. Menimo, da je tehnična analiza za trgovanje na slovenskem trgu koristen pripomoček, ki bo z nadaljnjim razvojem borze in njenih udeležencev še pridobival na pomenu.
Ključne besede: Borza, trgovanje, upravljanje z denarjem, delnice, donos, tehnična analiza, trend, indikatorji, trgovalni sistem treh zaslonov, obnašanje množic.
Objavljeno v DKUM: 30.06.2009; Ogledov: 2428; Prenosov: 258
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