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ELEKTRONSKI SISTEM ZA UPRAVLJANJE Z DOKUMENTI NA FAKULTETI ZA ORGANIZACIJSKE VEDE
Andrej Zupan, 2011, diplomsko delo

Opis: Upravljanje in organizirana hramba dokumentov postajata vse bolj pomembna in hkrati potratna dejavnost vsakega pisarniškega poslovanja. V primeru Fakultete za organizacijske vede smo zaznali problem upravljanja z dokumenti v okviru Projektne pisarne, s čimer se verjetno spopadajo tudi v drugih večjih podjetjih in javnih institucijah. V diplomskem delu smo pripravili predlog rešitve elektronskega upravljanja z dokumenti v Projektni pisarni, ki se kot strokovna podpora prijavljanju in izvajanju projektov na fakulteti že nekaj časa ukvarja z izzivom, kako na primeren način organizirati dokumente, kako jih spremljati v procesu, kako jih učinkovito hraniti. Pripravili smo analizo obstoječega stanja z vidika vodenja projektne dokumentacije. Zajeli smo proces prijavljanja projektov in spremljanja projektne dokumentacije. Načrt izgradnje oziroma organizacije sistema in izhodiščno točko smo pripravili na podlagi dobro razvitega sistema iz prakse. Predlagali smo ustrezen način upravljanja z dokumenti v Projektni pisarni FOV in opremljenost dokumentov z metapodatki. Za informatizacijo procesa upravljanja z dokumenti smo izbrali programsko rešitev Microsoft SharePoint 2010. Z implementacijo predlagane rešitve v prakso bi zaposleni na fakulteti prihranili precej časa, hkrati pa pridobili možnost dostopa do dokumentov vedno, povsod in v organizirani obliki.
Ključne besede: Dokumentacija, Projektna pisarna, Prenova procesa, Elektronski sistem za upravljanje z dokumenti, MS SharePoint
Objavljeno: 09.11.2011; Ogledov: 1845; Prenosov: 368
.pdf Celotno besedilo (4,71 MB)

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Long-term survival in glioblastoma: methyl guanine methyl transferase (MGMT) promoter methylation as independent favourable prognostic factor
Uroš Smrdel, Mara Popović, Matjaž Zwitter, Emanuela Boštjančič, Andrej Zupan, Viljem Kovač, Damjan Glavač, Drago Bokal, Janja Jerebic, izvirni znanstveni članek

Opis: Background: In spite of significant improvement after multi-modality treatment, prognosis of most patients with glioblastoma remains poor. Standard clinical prognostic factors (age, gender, extent of surgery and performance status) do not clearly predict long-term survival. The aim of this case-control study was to evaluate immuno-histochemical and genetic characteristics of the tumour as additional prognostic factors in glioblastoma. Patients and methods: Long-term survivor group were 40 patients with glioblastoma with survival longer than 30 months. Control group were 40 patients with shorter survival and matched to the long-term survivor group according to the clinical prognostic factors. All patients underwent multimodality treatment with surgery, postoperative conformal radiotherapy and temozolomide during and after radiotherapy. Biopsy samples were tested for the methylation of MGMT promoter (with methylation specific polymerase chain reaction), IDH1 (with immunohistochemistry), IDH2, CDKN2A and CDKN2B (with multiplex ligation-dependent probe amplification), and 1p and 19q mutations (with fluorescent in situ hybridization). Results: Methylation of MGMT promoter was found in 95% and in 36% in the long-term survivor and control groups, respectively (p < 0.001). IDH1 R132H mutated patients had a non-significant lower risk of dying from glioblastoma (p = 0.437), in comparison to patients without this mutation. Other mutations were rare, with no significant difference between the two groups. Conclusions: Molecular and genetic testing offers additional prognostic and predictive information for patients with glioblastoma. The most important finding of our analysis is that in the absence of MGMT promoter methylation, longterm survival is very rare. For patients without this mutation, alternative treatments should be explored.
Ključne besede: glioblastoma, long-term survival, methyl guanine methyl transferase, prognostic factor
Objavljeno: 05.04.2017; Ogledov: 355; Prenosov: 179
.pdf Celotno besedilo (556,97 KB)
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