Iskanje po katalogu digitalne knjižnice

Opis: Since the discovery of the first nanoparticles, scientists have developed controlled-release drugs, in which nanoparticles play a crucial role as drug carriers. Nanoparticles enable targeted and controlled release, but also face some challenges in their application, production and storage in vivo. The most used nanoparticles for drug encapsulation are liposomes. Liposomes consist of a lipid bilayer membrane that separates the inner hydrophilic/aqueous core from the surrounding environment. In the process known as encapsulation, an active ingredient is added that is either hydrophobic or hydrophilic. Their production is a challenge. Therefore, various production methods have been developed (thin film hydration, reverse phase evaporation, microfluidic methods, etc.) to achieve high encapsulation efficiency, stability and improved drug delivery in vivo. In medical treatment, liposomes are already used as carriers for analgesics, drugs to prevent and treat a variety of diseases (fungal, bacterial, and viral infections) and chemotherapeutics to treat various types of cancer (docetaxel, paclitaxel, doxorubicin, etc.). This article gives an insight into the methods of liposome production, ranging from conventional to more modern techniques with their advantages and disadvantages of the encapsulated substances and their use in medicine.
Ključne besede: nanoparticles, drug delivery, liposome preparation methods, liposome applications, medical substances, nanodelci, prenos zdravil, liposomi, medicinske sestavine
Objavljeno v DKUM: 06.11.2025; Ogledov: 0; Prenosov: 9
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Opis: Svetlobno onesnaževanje predstavlja obliko onesnaževanja okolja, ki v javnosti še ni v dovolj veliki meri prepoznana. V poglavju smo predstavili stanje svetlobnega onesnaženja na Dravskem polju in njegove spremembe v obdobju 2013-2021. Procese spreminjanja svetlobnega onesnaženja smo prikazali s pomočjo podatkov daljinskega zaznavanja. Drugi vir podatkov so predstavljale meritve s Sky Quality Metrom, ki v svetu predstavlja standardiziran način merjenja svetlobnega onesnaženja. Prostorske razlike v stopnji svetlobne onesnaženosti med posameznimi deli Dravskega polja smo prikazali tudi z vsenebnimi posnetki in njihovo analizo.
Ključne besede: Dravsko polje, radianca, daljinsko zaznavanje, prostorske razlike
Objavljeno v DKUM: 24.10.2025; Ogledov: 0; Prenosov: 6
Celotno besedilo (3,91 MB)
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Opis: Gallium nitride (GaN) technology has emerged as a transformative solution in the semiconductor industry due to its exceptional performance in highpower and high-frequency applications. With its inherent radiation resilience, GaN is particularly suited for environments such as space electronics and nuclear instrumentation. While static parameter testing under radiation has been extensively studied, dynamic parameter degradation—including propagation delays, rise/fall times, and efficiency losses—remains underexplored. These dynamic characteristics are useful for applications requiring precise timing, signal integrity, and rapid response, such as satellite communication and nuclear systems. This study evaluates the radiation resilience of three commercially available GaN transistors during a 100-krad (Si) Co-60 gamma irradiation campaign, with a focus on both static and dynamic parameters. Static parameters, such as threshold voltage and ON-state resistance, exhibited minimal degradation, while a larger change was observed in gate current. In contrast, dynamic parameters revealed smaller changes, including faster propagation delays and reduced efficiency, with variability observed across device types. The findings support a device-specific co-design of transistors and driver electronics for radiation-tolerant power stages
Ključne besede: Co-60 gamma, drain current, gallium nitride, GaN, gamma irradiation, gate current, in situ measurements, propagation delay, rise and fall times, voltage threshold
Objavljeno v DKUM: 17.10.2025; Ogledov: 0; Prenosov: 2
Celotno besedilo (1,97 MB)

Opis: V magistrski nalogi obravnavamo ekskurzije na vzgojno-izobraževalnem področju in njihovo priložnost medpredmetnega povezovanja geografije in zgodovine na območju Prekmurja. Teoretični del v prvem delu obravnava različne definicije ekskurzij, razvoj kompetenc udeležencev ekskurzije, cilje in naloge ekskurzij, odnos staršev do ekskurzij, različne delitvene kriterije ekskurzij in izpostavlja vse temeljne elemente, ki jih mora zaposlen v vzgojno-izobraževalni ustanovi (učitelj/profesor – organizator) upoštevati pri organiziranju ekskurzij. Drugi teoretični del zajema medpredmetno povezovanje geografije in zgodovine, medtem ko tretji del oriše pokrajino Prekmurje iz geografske in zgodovinske perspektive. V empiričnem delu, kjer smo analizirali 25 pripravljenih ekskurzij v Prekmurje (vzorec naše raziskave), naloženih na spletišču Uporabna geografija, ugotavljamo, da prevladujejo osnovnošolske, medpredmetne, regionalne, enodnevne ter digitalno-klasične ekskurzije v Prekmurje. Murska Sobota velja za najbolj obiskano lokacijo, medtem ko Plečnikova cerkev v naselju Bogojina za najbolj obiskano znamenitost Prekmurja. Avtorji ekskurzij so za največkrat uporabljeni didaktični pripomoček izbrali zemljevid. Ugotavljamo, da med pripravljenimi ekskurzijami prevladujejo geografski cilji, vsebine in naloge. Opisovanje (ponekod v obliki krajših odgovorov na vprašanja) velja za največkrat uporabljen tip dejavnosti. Geografske in zgodovinske tematike se na določenih lokacijah pojavljajo tako posamično, kot tudi medpredmetno prepleteno. S SWOT analizo predstavimo pozitivne in negativne značilnosti pripravljenih ekskurzij v Prekmurje, v aplikativnem delu naloge pa izdelamo primer didaktično ustrezne geografsko-zgodovinske ekskurzije v Prekmurje.
Ključne besede: ekskurzija, Uporabna geografija, vzgoja, izobraževanje, Prekmurje
Objavljeno v DKUM: 06.10.2025; Ogledov: 0; Prenosov: 8
Celotno besedilo (5,79 MB)

Opis: Background/Objectives: This research focuses on the increasing presence of older workers in the labor market, a group particularly vulnerable to hearing problems due to age-related changes and prolonged noise exposure. Methods: The research combines theoretical and empirical approaches to investigate the impact of noise on the workplaces of older employees. The empirical component is based on two primary methods: a survey and audiometric testing to assess participants’ hearing abilities. The study included a sample of 50 older workers, all with diagnosed hearing loss. Results: The results of the survey showed that most older workers are regularly exposed to noise at work, which has long-term negative effects on their hearing. This highlights the need to introduce appropriate protective measures such as personal protective equipment, insulation of noise sources, and raising awareness about the dangers of noise. In addition to the questionnaire survey, the analysis of hearing measurements revealed that all respondents had significant bilateral hearing loss, with sensorineural hearing loss being the most prevalent type. Conclusions: This study highlights the negative impact of chronic noise exposure in the workplace on the hearing, communication and productivity of older workers and emphasizes the importance of combining preventive measures, hearing protection and workplace adaptations to promote their well-being and performance.
Ključne besede: hearing dysfunction, older workers, noise exposure, ergonomics, audiometric assessments, workers’ perception
Objavljeno v DKUM: 04.09.2025; Ogledov: 0; Prenosov: 2
Celotno besedilo (306,64 KB)
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