Iskanje po katalogu digitalne knjižnice

Opis: The interaction of microorganisms and their enzyme activity is one of the key indicators for a comprehensive measurement of soil health. The aim of this study was to determine significant correlations between different soil microorganisms and enzyme activities of β-glucosidase, N-acetyl-glucosaminidase, urease, arylamidase, phosphatase, acid phosphatase, alkaline phosphatase, and arylsulfatase after supplementation with standard fertilizer, spent mushroom substrate and composed fertilizer in soils from conventional–integrated, organic and biodynamic farming. Samples were grouped according to the farming system and fertilization for all seasons. The biodynamic farm was the least affected by the different fertilizations, except for standard fertilization. Standard fertilizer caused negative correlations between the actinomycetes and the arylsulfatase in organic and biodynamic farms. The same fertilization affected the actinomycetes/phosphatase relationship differently, regardless of the basic soil structure. Actinomycetes correlated positively with acid phosphatase and urease in conventional–integrated and biodynamic farms after spent mushroom substrate, respectively. Arylamidase activity in relation to total microorganisms responded to fertilization with standard fertilizer and spent mushroom substrate independently of the basic soil structure. Fertilization can influence the soil microbe/enzyme relationships in different soils. Regardless of the basic soil structure, some of these relationships could be important indicators for further studies.
Ključne besede: agriculture, conventional-integrated, organic, biodynamic, fertilization, soil microorganisms, soil enzyme activity
Objavljeno v DKUM: 17.04.2025; Ogledov: 0; Prenosov: 0
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Opis: Objective: One potential strategy to address inadequate screening for somatic comorbidities among patients with mental disorders is to integrate a clinical pharmacist into the inpatient team for daily interdisciplinary ward rounds. This approach remains under-researched in psychiatric hospitals. This study aimed to evaluate the impact of a clinical pharmacist on drug-related problems (DRPs) during daily ward rounds within an interdisciplinary team in a psychiatric hospital. Methods: A retrospective observational pre-post study was conducted at the Ormož Psychiatric Hospital in Slovenia, including patients treated between 2019 and 2020, during which clinical pharmacists offered recommendations during daily ward rounds. The primary outcomes assessed the difference in the total number of DRPs observed at the time of hospital discharge compared to previous stage, as well as the recommendations and their continuation rate after three months. The secondary outcomes evaluated adherence to treatment guidelines. Results: The study included 186 patients (mean age: 58.1 years, SD=17.0). During ward rounds, 280 recommendations related to DRPs were conducted (1.5 recommendations per patient). Regarding the nature of DRPs, 154 (55.0%) were identified as expressed DRPs, while 127 (45.0%) were deemed potential DRPs. Following pharmacist recommendations, 133 (86.4%) of the expressed DRPs were successfully resolved. The majority of DRPs pertained to treatment effectiveness (N=179, 63.9%), followed by unnecessary treatments (N=86, 30.7%) and patient safety (N=15, 5.4%). Initially, the acceptance rate of recommendations was 88.9% (N=249) at discharge, declining to 63.2% (N=177) three months after discharge. The acceptance rate for somatic conditions at discharge was 87.8% (N=122), declining to 59.0% (N=82) three months after discharge. Adherence to treatment guidelines for somatic comorbidities increased (p < 0.05). Conclusions: The results indicate that this approach led to fewer DRPs, a high rate of acceptance, and better adherence to treatment guidelines. This is the first retrospective pre-post study in the European Union to include this collaboration in daily rounds at psychiatric hospitals, focusing on somatic comorbidities. However, the study also has significant limitations, such as its non-randomized design and short monitoring period, which should be addressed in future research.
Ključne besede: psychiatry, clinical pharmacy, hospital, ward rounds, drug-related problem
Objavljeno v DKUM: 07.01.2025; Ogledov: 0; Prenosov: 7
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Opis: Clinical pharmacists have not yet become an integral part of interdisciplinary ward rounds in most psychiatric hospitals across the European Union. This retrospective observational pre-post study examined the impact of clinical pharmacist recommendations in an interdisciplinary medical team during psychiatric hospital rounding. The study included all patients in a Slovenian psychiatric hospital who were hospitalized 2019-2020. The clinical pharmacist made 315 recommendations for a total of 224 participants (average age M = 59.4, median = 56). Psychiatrists accepted 295 (93.7%) of the recommendations. After the recommendations, the number of expressed and potential drug-related problems decreased in 166 (93.8%) and 129 (93.8%) interventions, respectively. Three months after discharge, 222 accepted recommendations were continued (70.5%). The most common recommendations were related to antipsychotics (19.4%, N = 61) followed by antidepressants (16.8%, N = 53). Including a clinical pharmacist in the interdisciplinary ward rounds at a psychiatric hospital reduced the number of expressed and potential drug-related problems with a very high recommendation acceptance rate. These results are the first in Central Europe to explore the benefits of including a clinical pharmacist in ward rounding.
Ključne besede: clinical pharmacist, clinical pharmacy, psychiatry
Objavljeno v DKUM: 10.12.2024; Ogledov: 0; Prenosov: 1090
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Opis: Slovenska esejistika je od začetkov naprej sledila književnemu dogajanju. Pisala je o posameznih literarnih opusih, književnonazorskih temah, estetskih in kriti{kih vprašanjih, literarni fenomenologiji, idejnih podlagah književnosti itn. Začetke sistematičnega ukvarjanja s slovstvom postavljam v prvo polovico 20. stoletja; kasneje so med pisci vsi pomembni slovenski esejisti.
Ključne besede: slovenska esejistika, slovenska književnost, književna problematika, literarna fenomenologija
Objavljeno v DKUM: 29.07.2024; Ogledov: 89; Prenosov: 7
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Opis: Clinical pharmacy as an area of practice, education and research started developing around the 1960s when pharmacists across the globe gradually identified the need to focus more on ensuring the appropriate use of medicines to improve patient outcomes rather than being engaged in manufacturing and supply. Since that time numerous studies have shown the positive impact of clinical pharmacy services (CPS). The need for wider adoption of CPS worldwide becomes urgent, as the global population ages, and the prevalence of polypharmacy as well as shortage of healthcare professionals is rising. At the same time, there is great pressure to provide both high-quality and cost-effective health services. All these challenges urgently require the adoption of a new paradigm of healthcare system architecture. One of the most appropriate answers to these challenges is to increase the utilization of the potential of highly educated and skilled professionals widely available in these countries, i.e., pharmacists, who are well positioned to prevent and manage drug-related problems together with ensuring safe and effective use of medications with further care relating to medication adherence. Unfortunately, CPS are still underdeveloped and underutilized in some parts of Europe, namely, in most of the Central and Eastern European (CEE) countries. This paper reviews current situation of CPS development in CEE countries and the prospects for the future of CPS in that region.
Ključne besede: clinical pharmacy, cost-effective treatment, drug safety, drug utilization, health policy, medication adherence, medication errors, polypharmacy
Objavljeno v DKUM: 27.05.2024; Ogledov: 190; Prenosov: 15
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