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Optimal governance and implementation of vaccination programmes to contain the COVID-19 pandemic
Mahendra Piraveenan, Shailendra Sawleshwarkar, Michael Walsh, Iryna Zablotska, Samit Bhattacharyya, Habib Hassan Farooqui, Tarun Bhatnagar, Anup Karan, Manoj Murhekar, Sanjay P. Zodpey, K. S. Mallikarjuna Rao, Philippa Pattison, Albert Y. Zomaya, Matjaž Perc, 2021, original scientific article

Abstract: Since the recent introduction of several viable vaccines for SARS-CoV-2, vaccination uptake has become the key factor that will determine our success in containing the COVID-19 pandemic. We argue that game theory and social network models should be used to guide decisions pertaining to vaccination programmes for the best possible results. In the months following the introduction of vaccines, their availability and the human resources needed to run the vaccination programmes have been scarce in many countries. Vaccine hesitancy is also being encountered from some sections of the general public. We emphasize that decision-making under uncertainty and imperfect information, and with only conditionally optimal outcomes, is a unique forte of established game-theoretic modelling. Therefore, we can use this approach to obtain the best framework for modelling and simulating vaccination prioritization and uptake that will be readily available to inform important policy decisions for the optimal control of the COVID-19 pandemic.
Keywords: COVID-19, evolutionary game theory, digital epidemiology, vaccination, social network, public goods game, social physics
Published in DKUM: 28.02.2025; Views: 0; Downloads: 3
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3.
Assortative mixing of opinions about COVID‑19 vaccination in personal networks
Marian-Gabriel Hâncean, Jürgen Lerner, Matjaž Perc, José Luis Molina González, Marius Geanta, 2024, original scientific article

Abstract: Many countries worldwide had difculties reaching a sufciently high vaccination uptake during the COVID-19 pandemic. Given this context, we collected data from a panel of 30,000 individuals, which were representative of the population of Romania (a country in Eastern Europe with a low 42.6% vaccination rate) to determine whether people are more likely to be connected to peers displaying similar opinions about COVID-19 vaccination. We extracted 443 personal networks, amounting to 4430 alters. We estimated multilevel logistic regression models with random-ego-level intercepts to predict individual opinions about COVID-19 vaccination. Our evidence indicates positive opinions about the COVID-19 vaccination cluster. Namely, the likelihood of having a positive opinion about COVID-19 vaccination increases when peers have, on average, a more positive attitude than the rest of the nodes in the network (OR 1.31, p < 0.001). We also found that individuals with higher education and age are more likely to hold a positive opinion about COVID-19 vaccination. With the given empirical data, our study cannot reveal whether this assortative mixing of opinions is due to social infuence or social selection. However, it may nevertheless have implications for public health interventions, especially in countries that strive to reach higher uptake rates. Understanding opinions about vaccination can act as an early warning system for potential outbreaks, inform predictions about vaccination uptake, or help supply chain management for vaccine distribution.
Keywords: assortative mixing, opinions, vaccination, personal network, social physics
Published in DKUM: 27.11.2024; Views: 0; Downloads: 4
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Socio-demographic and health factors drive the epidemic progression and should guide vaccination strategies for best COVID-19 containment
Rene Markovič, Marko Šterk, Marko Marhl, Matjaž Perc, Marko Gosak, 2021, original scientific article

Abstract: We propose and study an epidemiological model on a social network that takes into account heterogeneity of the population and different vaccination strategies. In particular, we study how the COVID-19 epidemics evolves and how it is contained by different vaccination scenarios by taking into account data showing that older people, as well as individuals with comorbidities and poor metabolic health, and people coming from economically depressed areas with lower quality of life in general, are more likely to develop severe COVID-19 symptoms, and quicker loss of immunity and are therefore more prone to reinfection. Our results reveal that the structure and the spatial arrangement of subpopulations are important epidemiological determinants. In a healthier society the disease spreads more rapidly but the consequences are less disastrous as in a society with more prevalent chronic comorbidities. If individuals with poor health are segregated within one community, the epidemic outcome is less favorable. Moreover, we show that, contrary to currently widely adopted vaccination policies, prioritizing elderly and other higher-risk groups is beneficial only if the supply of vaccine is high. If, however, the vaccination availability is limited, and if the demographic distribution across the social network is homogeneous, better epidemic outcomes are achieved if healthy people are vaccinated first. Only when higher-risk groups are segregated, like in elderly homes, their prioritization will lead to lower COVID-19 related deaths. Accordingly, young and healthy individuals should view vaccine uptake as not only protecting them, but perhaps even more so protecting the more vulnerable socio-demographic groups.
Keywords: epidemic model, COVID-19, vaccination strategy, vaccination strategy, population heterogeneity, socio-demographic structure, metabolic disease, social network
Published in DKUM: 14.11.2024; Views: 0; Downloads: 12
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5.
COVID-19 vaccine boosters: the good, the bad, and the ugly
Piotr Rzymski, Carlos A. Camargo, Andrzej Fal, Robert Flisiak, Willis Gwenzi, Roya Kelishadi, Alexander Leemans, Juan J. Nieto, Ahmet Ozen, Matjaž Perc, Barbara Poniedziałek, Constantine Sedikides, Frank W. Sellke, Emilia C. Skirmuntt, Anzhela Stashchak, Nima Rezaei, 2021, original scientific article

Abstract: Pursuing vaccinations against COVID-19 brings hope to limit the spread of SARS-CoV-2 and remains the most rational decision under pandemic conditions. However, it does not come without challenges, including temporary shortages in vaccine doses, significant vaccine inequity, and questions regarding the durability of vaccine-induced immunity that remain unanswered. Moreover, SARS-CoV-2 has undergone evolution with the emergence of its novel variants, characterized by enhanced transmissibility and ability to at least partially evade neutralizing antibodies. At the same time, serum antibody levels start to wane within a few months after vaccination, ultimately increasing the risk of breakthrough infections. This article discusses whether the administration of booster doses of COVID-19 vaccines is urgently needed to control the pandemic. We conclude that, at present, optimizing the immunity level of wealthy populations cannot come at the expense of low-income regions that suffer from vaccine unavailability. Although the efficiency of vaccination in protecting from infection may decrease over time, current data show that efficacy against severe disease, hospitalization, and death remains at a high level. If vaccine coverage continues at extremely low levels in various regions, including African countries, SARS-CoV-2 may sooner or later evolve into variants better adapted to evade natural and vaccine-induced immunity, ultimately bringing a global threat that, of course, includes wealthy populations. We offer key recommendations to increase vaccination rates in low-income countries. The pandemic is, by definition, a major epidemiological event and requires looking beyond one's immediate self-interest; otherwise, efforts to contain it will be futile.
Keywords: COVID-19, pandemic, disease dynamics, exponential growth, virality, vaccination strategy, immunology, massive vaccinations, vaccine inequity, SARS-CoV-2
Published in DKUM: 14.10.2024; Views: 0; Downloads: 9
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6.
Factors affecting attitudes towards COVID-19 vaccination : an online survey in Slovenia
Luka Petravić, Rok Arh, Tina Gabrovec, Lucija Jazbec, Nika Rupčić, Nina Starešinič, Lea Zorman, Ajda Pretnar Žagar, Andrej Srakar, Matjaž Zwitter, Ana Slavec, 2021, original scientific article

Abstract: While the problem of vaccine hesitancy is not new, it has become more pronounced with the new COVID-19 vaccines and represents an obstacle to resolving the crisis. Even people who would usually trust vaccines and experts now prefer to wait for more information. A cross-sectional online survey was conducted in Slovenia in December 2020 to find out the attitudes of the population regarding COVID-19 vaccination and the factors that affect these attitudes. Based on 12,042 fully completed questionnaires, we find that higher intention to get vaccinated is associated with men, older respondents, physicians and medical students, respondents who got the influenza vaccination, those who knew someone who had gotten hospitalised or died from COVID-19 and those who have more trust in experts, institutions and vaccines. Nurses and technicians were less likely to get vaccinated. In answers to an open question, sceptics were split into those doubting the quality due to the rapid development of the vaccine and those that reported personal experiences with side effects of prior vaccinations. Although the Slovenian population is diverse in its attitudes towards vaccination, the results are comparable to those found in other countries. However, there are potential limitations to the generalizability of the findings that should be addressed in future studies.
Keywords: cross-sectional studies, intention, public opinion, trust, ordinal regression, COVID-19, vaccination, surveys and questionnaires, Europe, immune system, SARS-CoV-2
Published in DKUM: 10.10.2024; Views: 0; Downloads: 10
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7.
Risk assessment of COVID-19 epidemic resurgence in relation to SARS-CoV-2 variants and vaccination passes
Tyll Krüger, Krzysztof Gogolewski, Marcin Bodych, Anna Gambin, Giulia Giordano, Sarah Cuschieri, Thomas Czypionka, Matjaž Perc, Elena Petelos, Magdalena Rosińska, Ewa Szczurek, 2022, original scientific article

Abstract: The introduction of COVID-19 vaccination passes (VPs) by many countries coincided with the Delta variant fast becoming dominant across Europe. A thorough assessment of their impact on epidemic dynamics is still lacking. Here, we propose the VAP-SIRS model that considers possibly lower restrictions for the VP holders than for the rest of the population, imperfect vaccination effectiveness against infection, rates of (re-)vaccination and waning immunity, fraction of never-vaccinated, and the increased transmissibility of the Delta variant. Some predicted epidemic scenarios for realistic parameter values yield new COVID-19 infection waves within two years, and high daily case numbers in the endemic state, even without introducing VPs and granting more freedom to their holders. Still, suitable adaptive policies can avoid unfavorable outcomes. While VP holders could initially be allowed more freedom, the lack of full vaccine effectiveness and increased transmissibility will require accelerated (re-)vaccination, wide-spread immunity surveillance, and/or minimal long-term common restrictions.
Keywords: SIRS model, vaccination pass, stability analysis
Published in DKUM: 15.07.2024; Views: 105; Downloads: 15
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8.
Turkey’s transition to face-to-face schooling during the COVID-19 pandemic
Mahmut Özer, H. Eren Suna, Matjaž Perc, Sadri Şensoy, Sevil Uygun İli̇khan, 2022, original scientific article

Abstract: Background/aim: The COVID-19 pandemic majorly disrupted conventional schooling and many countries maintained educational services through distance education. The duration of school closures in Turkey was longer than most OECD countries, thus Turkey prioritized school reopenings in the 2021-2022 academic year to mitigate possible negative outcomes of closures. Here we study the compatibility of implications for school reopenings in Turkey with these practices and assess the first semester of face-to-face schooling. Materials and methods: We have used document analysis to present and compare the practices in Turkey with international practices. We also used a comparative approach to assess the coherence between policies in Turkey and international suggestions. Results: We find that vaccination rates of teachers and education staff are quite high in Turkey. Other practices, mandatory face masks, class-based closures and quarantine policies, are also in agreement with international practices. These steps are supported with frequent cleaning and ventilation of school environments, as well as with social distancing measures in schools. Conclusion: Consequently, the rate of daily closed classrooms has been kept below 1%, and the patterns of closures and openings are in general agreement with the changes of positive cases in the Turkish society. The net rate of closed classrooms decreased with the decline of quarantine days in Turkey. We hope that these insights will inform about school openings and contribute to best practices for faceto-face schooling.
Keywords: school system, school reopening, face-to-face education, COVID-19, educational equality, vaccination
Published in DKUM: 11.07.2024; Views: 100; Downloads: 5
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9.
Differences in treating patients with palpitations at the primary healthcare level using telemedical device Savvy before and during the COVID-19 pandemic
Staša Vodička, Erika Zelko, 2022, original scientific article

Abstract: Background: Palpitations are one of most common reasons why a patient visits a general practitioner (GP) and is referred to a cardiologist. Coronavirus disease 2019 (COVID-19) has been associated with new-onset arrhythmias, which are difficult to diagnose at the primary healthcare level during pandemic-related lockdown periods. Methods: A total of 151 patients with a complaint of heart rhythm disorder were included from before and during the COVID-19 pandemic, as well as after the start of vaccination, in this cohort retrospective study. We used a telemedical device-namely, a personal electrocardiographic (ECG) sensor called Savvy-to investigate heart rhythm in patients. The primary outcome of the study was to evaluate the number of actual heart rhythm disorder patients and any differences that infection with or vaccination for COVID-19 had on patients handled in a primary healthcare setting. Results: We found a heart rhythm disorder in 8.6% of patients before the COVID-19 pandemic and in 15.2-17.9% of patients during the COVID-19 pandemic, where the difference was statistically significant (p = 0.002). During the COVID-19 pandemic, we found a heart rhythm disorder in almost 50% of patients that had tested positive for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 virus) more than one month ago. After the vaccinations started, we also found a heart rhythm disorder in almost 50% of non-vaccinated patients. Conclusions: Using a telemedical approach or remote consultation is a useful method, at the primary healthcare level, for diagnosing and treating patients with palpitations during times of lockdown.
Keywords: COVID-19 infection, COVID-19 vaccination, cardiac arrhythmia, primary healthcare level, referrals, telemedicine
Published in DKUM: 08.07.2024; Views: 68; Downloads: 11
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10.
The influence of anxiety and fear of COVID‑19 on vaccination hesitancy among postsecondary students
Andrej Šorgo, Nuša Crnkovič, Katarina Cesar, Špela Selak, Mitja Vrdelja, Branko Gabrovec, 2022, original scientific article

Abstract: The aim of the present study was to explore the infuence of anxiety and fear of COVID-19 on vaccination hesitancy among Slovenian postsecondary students. A cross-sectional study using a set of previously tested instruments and ad hoc questions created by the authors was chosen as the method to gain insight into various health and sociodemographic aspects of Slovenian postsecondary students afected by the COVID-19-induced closures and suspensions of educational activities at tertiary educational institutions (N= 5999). Overall, 39.7% of participating students expressed an intention to get vaccinated at the frst possible opportunity, whereas 29.2% expressed no intent to do so. The highest vaccine hesitancy was observed among prospective teachers (50.3%) and the lowest among prospective physicians (5,7%). When examining the role of anxiety and fear of COVID-19 on the Slovenian postsecondary students' intentions to get vaccinated the results of logistic regression showed that only fear of COVID-19 played a mild and signifcant role.
Keywords: vaccination, health care, health occupations, medical research, risk factors, signs and symptoms, students
Published in DKUM: 05.07.2024; Views: 111; Downloads: 9
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