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Optimisation of the green process of industrial hemp - preparation and its extract characterisationTaja Žitek Makoter,
Petra Kotnik,
Teo Makoter,
Vesna Postružnik,
Željko Knez,
Maša Knez Marevci, 2022, original scientific article
Abstract: Natural medicines and products are becoming increasingly important in the pharmaceutical
and food industries. The most important step in obtaining a natural remedy is the processing of
the natural material. This study offers the separation of the industrial hemp plant into fractions by
mechanical treatment, which has a significant impact on the selectivity of the obtained fractions. This
study also offers a solution to reduce waste by fractionating industrial hemp, focusing on the fraction
with the highest cannabinoid content (49.5% of CBD). The study confirmed the anticancer potential
of the extract, which prevents further division of WM-266-4 melanoma cells at a concentration of
10−3 mg/mL. However, application of the extract (c = 10−3 mg/mL) to normal human epidermal
melanocytes proved to be insignificant, as the metabolic activity of the cells was the same as in the
control cell group.
Keywords: supercritical fluid extraction, ultrasonic extraction, melanoma cells, extraction, WM-266-4
Published in DKUM: 09.05.2025; Views: 0; Downloads: 10
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